CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

Identification of the familial cylindromatosis tumour-suppressor gene

2000 • 654 citations

Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

2002 • 599 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr Virus LMP1 Domain Important for B-Lymphocyte Transformation: Role in NF-κB Activation

1996 • 491 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Involvement of a novel Tnf receptor homologue in hair follicle induction

1999 • 385 citations

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

2001 • 384 citations

Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

2000 • 303 citations

Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus

1995 • 277 citations

Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.

1996 • 228 citations

TRAF6 -deficient mice display hypohidrotic ectodermal dysplasia

2002 • 177 citations

Tumor Necrosis Factor (TNF)-induced Germinal Center Kinase-related (GCKR) and Stress-activated Protein Kinase (SAPK) Activation Depends upon the E2/E3 Complex Ubc13-Uev1A/TNF Receptor-associated Factor 2 (TRAF2)

2003 • 172 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

TRAF2 Deficiency Results in Hyperactivity of Certain TNFR1 Signals and Impairment of CD40-Mediated Responses

1999 • 133 citations

Identification of a Novel Death Domain-Containing Adaptor Molecule for Ectodysplasin-A Receptor that Is Mutated in crinkled Mice

2002 • 123 citations

TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1

2001 • 120 citations

An NMR-based Model of the Ubiquitin-bound Human Ubiquitin Conjugation Complex Mms2·Ubc13

2003 • 94 citations

Cellular signaling pathways engaged by the Epstein-Barr virus transforming protein LMP1

2002 • 59 citations

Ultraspiracle, a Drosophila Retinoic X Receptor α Homologue, Can Mobilize the Human Thyroid Hormone Receptor To Transactivate a Human Promoter

1997 • 35 citations