Molecular Mechanisms and Pathophysiology of Necrotic Cell Death

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

2007 • 895 citations

Curcumin: Getting Back to the Roots

2005 • 692 citations

TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

2007 • 504 citations

Patterns of cell death.

1988 • 470 citations

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

1997 • 422 citations

Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells

2003 • 415 citations

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

2002 • 313 citations

Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis

2007 • 312 citations

Intralysosomal iron: a major determinant of oxidant-induced cell death

2003 • 222 citations

Metal Chelation as a Potential Therapy for Alzheimer's Disease

2000 • 211 citations

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

2000 • 200 citations

Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

2006 • 196 citations

A Randomized, Double-Blind, Placebo-Controlled Trial of Two Doses of Ginkgo Biloba Extract in Dementia of the Alzheimers Type

2005 • 171 citations

Hsp72-Mediated Suppression of c-Jun N-Terminal Kinase Is Implicated in Development of Tolerance to Caspase-Independent Cell Death

2000 • 161 citations

Tumor necrosis factor-α-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool

2007 • 99 citations

Involvement of heat shock protein-70 in the mechanism of hydrogen peroxide-induced DNA damage: The role of lysosomes and iron

2006 • 63 citations

Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells

2005 • 51 citations