Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Apoptosis by Death Factor

1997 • 5,038 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

The biochemistry of programmed cell death

1995 • 997 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.

1987 • 482 citations

Biologic Therapy of Cancer

1992 • 476 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options

1997 • 405 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Liver cell necrosis: Cellular mechanisms and clinical implications

1995 • 393 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1997 • 353 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Interleukin-6 Induction by Tumor Necrosis Factor and Interleukin-1 in Human Fibroblasts Involves Activation of a Nuclear Factor Binding to a κΒ-Like Sequence

1990 • 269 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Cell death induction by receptors of the TNF family: towards a molecular understanding

1997 • 237 citations

TUMOUR NECROSIS FACTOR-INDUCED NECROSIS VERSUS ANTI-Fas-INDUCED APOPTOSIS IN L929 CELLS

1997 • 151 citations

Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis.

1988 • 142 citations

The role of protein degradation in mitochondrial function and biogenesis

1996 • 105 citations

Apoptosis: alive and kicking in 1997

1997 • 104 citations

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity

1993 • 97 citations

Endogenous free radical generation may influence proteolysis in Mitochondria

1985 • 76 citations

Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects

1997 • 68 citations

Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system.

1994 • 61 citations

Mechanisms Involved in the Induction of Human Endothelial Cell Necrosis

1996 • 26 citations

Deleted Work

1955 • 0 citations