Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Proteases to die for

1998 • 1,241 citations

NF-kB in development and progression of human cancer

2005 • 1,083 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

2004 • 821 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

2004 • 526 citations

The RIP kinases: crucial integrators of cellular stress

2005 • 370 citations

Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis

2003 • 363 citations

Apoptosis Induced by the Toll-Like Receptor Adaptor TRIF Is Dependent on Its Receptor Interacting Protein Homotypic Interaction Motif

2005 • 353 citations

Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

2002 • 336 citations

RIP3, a Novel Apoptosis-inducing Kinase

1999 • 222 citations

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF‐κB and is processed during apoptosis

2002 • 137 citations

Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c‐IAP1 and c‐IAP2) in vitro

2004 • 131 citations

Activation of a pro‐apoptotic amplification loop through inhibition of NF‐κB‐dependent survival signals by caspase‐mediated inactivation of RIP

2000 • 130 citations

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFκB

1999 • 129 citations

The RIP‐like kinase, RIP3, induces apoptosis and NF‐κB nuclear translocation and localizes to mitochondria

2000 • 114 citations

Mouse Receptor Interacting Protein 3 Does Not Contain a Caspase-Recruiting or a Death Domain but Induces Apoptosis and Activates NF-κB

1999 • 59 citations

Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis

2001 • 59 citations

Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis

2003 • 58 citations

Nucleocytoplasmic Shuttling of Receptor-interacting Protein 3 (RIP3)

2004 • 48 citations

Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells

2004 • 46 citations

RIP3 β and RIP3 γ, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis

2005 • 28 citations