Necrotic cell death and ‘necrostatins’: now we can control cellular explosion

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

2005 • 2,694 citations

Identification of RIP1 kinase as a specific cellular target of necrostatins

2008 • 1,837 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Cell death by necrosis: towards a molecular definition

2006 • 989 citations

Necrotic death as a cell fate

2006 • 873 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

The morphology of various types of cell death in prenatal tissues

1973 • 716 citations

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

2006 • 662 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

2007 • 504 citations

Compartmentalization of TNF Receptor 1 Signaling

2004 • 479 citations

RIP1, a kinase on the crossroads of a cell's decision to live or die

2007 • 456 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Caspase-independent programmed cell death with necrotic morphology

1999 • 378 citations

The RIP kinases: crucial integrators of cellular stress

2005 • 370 citations

Necrostatin: A Potentially Novel Cardioprotective Agent?

2007 • 305 citations

The Kinase Activity of Rip1 Is Not Required for Tumor Necrosis Factor-α-induced IκB Kinase or p38 MAP Kinase Activation or for the Ubiquitination of Rip1 by Traf2

2004 • 251 citations

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601

2000 • 239 citations

The Cardioprotective Effect of Necrostatin Requires the Cyclophilin-D Component of the Mitochondrial Permeability Transition Pore

2007 • 164 citations

The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

2003 • 128 citations

Structure–activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

2006 • 119 citations

The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase

2003 • 97 citations

Activation segment exchange: a common mechanism of kinase autophosphorylation?

2007 • 94 citations

Structure−Activity Relationship Study of Tricyclic Necroptosis Inhibitors

2007 • 78 citations

Compartmentalization of TNF Receptor 1 SignalingInternalized TNF Receptosomes as Death Signaling Vesicles

2004 • 48 citations