Involvement of linear polyubiquitylation of NEMO in NF-κB activation

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Signaling to NF-κB

2004 • 3,768 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

2000 • 1,801 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

Ubiquitin signalling in the NF-κB pathway

2005 • 1,137 citations

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

2003 • 1,102 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

2006 • 956 citations

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair

1999 • 814 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

A ubiquitin ligase complex assembles linear polyubiquitin chains

2006 • 752 citations

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

2008 • 543 citations

Sequential Modification of NEMO/IKKγ by SUMO-1 and Ubiquitin Mediates NF-κB Activation by Genotoxic Stress

2003 • 542 citations

Ubiquitin-mediated activation of TAK1 and IKK

2007 • 435 citations

The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO

2004 • 378 citations

Signals from within: the DNA-damage-induced NF-κB response

2006 • 295 citations

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

2006 • 264 citations

Modes of regulation of ubiquitin-mediated protein degradation

2000 • 259 citations

The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

2006 • 225 citations

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

2004 • 220 citations

Protein partners of deubiquitinating enzymes

2008 • 186 citations

Enhancement of immunoblot sensitivity by heating of hydrated filters

1986 • 168 citations

Deubiquitinating Enzymes as Cellular Regulators

2003 • 160 citations

Targeting NF-κB in hematologic malignancies

2006 • 155 citations

Multiple ubiquitin mRNAs during xenopus laevis development contain tandem repeats of the 76 amino acid coding sequence

1984 • 130 citations

NF-κB and JNK: An Intricate Affair

2004 • 109 citations

Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling

2006 • 81 citations

Automated interpretation of low-energy collision-induced dissociation spectra by SeqMS, a software aid forde novo sequencing by tandem mass spectrometry

2000 • 72 citations

Two Carboxyl-terminal Activation Regions of Epstein-Barr Virus Latent Membrane Protein 1 Activate NF-κB through Distinct Signaling Pathways in Fibroblast Cell Lines

2003 • 67 citations

The Hepatitis B Virus X-associated Protein, XAP3, Is a Protein Kinase C-binding Protein

1997 • 62 citations

Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti

2007 • 58 citations

Molecular Cloning and Characterization of a Novel Protein Kinase C-Interacting Protein with Structural Motifs Related to RBCC Family Proteins

1998 • 55 citations

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex

2006 • 49 citations

Finding NEMO by K63-linked polyubiquitin chain

2006 • 48 citations

Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells

2004 • 28 citations

Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells

1987 • 17 citations