TNFα and reactive oxygen species in necrotic cell death

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

2008 • 3,166 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Mitochondria, oxidative stress and cell death

2007 • 1,850 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Death by design: apoptosis, necrosis and autophagy

2004 • 1,330 citations

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

2004 • 1,204 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation

2001 • 1,092 citations

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1999 • 850 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

2005 • 795 citations

Death receptor-induced cell killing

2003 • 756 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Role of JNK activation in apoptosis: A double-edged sword

2005 • 704 citations

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

2006 • 662 citations

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

2004 • 625 citations

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

2005 • 605 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

2007 • 504 citations

NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

2003 • 494 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

RIP1, a kinase on the crossroads of a cell's decision to live or die

2007 • 456 citations

A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses

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Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation

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Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

2003 • 366 citations

Controlled Elimination of Intracellular H₂O2: Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification

2005 • 357 citations

Reactive oxygen species mediate crosstalk between NF-κB and JNK

2005 • 344 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2

2004 • 312 citations

Glutathione S-transferase P1–1 (GSTP1–1) Inhibits c-Jun N-terminal Kinase (JNK1) Signaling through Interaction with the C Terminus

2001 • 304 citations

A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

2006 • 299 citations

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

2004 • 294 citations

TNF receptor superfamily‐induced cell death: redox‐dependent execution

2006 • 281 citations

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

2003 • 274 citations

Linking JNK signaling to NF-κB: a key to survival

2004 • 266 citations

Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis

2005 • 236 citations

Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

1997 • 231 citations

PKCζ Regulates TNF-α–Induced Activation of NADPH Oxidase in Endothelial Cells

2002 • 220 citations

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death

2005 • 214 citations

Caspase Inhibitors Promote Alternative Cell Death Pathways

2006 • 210 citations

NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

2004 • 203 citations

Oxidative stress and cell death

2003 • 198 citations

Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells

2006 • 191 citations

Link between Mitochondria and NADPH Oxidase 1 Isozyme for the Sustained Production of Reactive Oxygen Species and Cell Death

2006 • 184 citations

The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction

2006 • 171 citations

Redox regulation of protein-tyrosine phosphatases

2004 • 164 citations

TNF-α Induces Phosphorylation of p47phox in Human Neutrophils: Partial Phosphorylation of p47phox Is a Common Event of Priming of Human Neutrophils by TNF-α and Granulocyte-Macrophage Colony-Stimulating Factor

2003 • 158 citations

Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas‐mediated apoptosis

1998 • 148 citations

Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

2004 • 145 citations

TNF-α activates at least two apoptotic signaling cascades

1998 • 144 citations

Differential Oxidation of Protein-tyrosine Phosphatases

2004 • 139 citations

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

2002 • 138 citations

Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells

2000 • 137 citations

Redox regulation of TNF signaling

1999 • 133 citations

Redox-Linked Signal Transduction Pathways for Protein Tyrosine Kinase Activation

2002 • 125 citations

Death receptors

2003 • 122 citations

Selective Inactivation of a Fas-associated Death Domain Protein (FADD)-dependent Apoptosis and Autophagy Pathway in Immortal Epithelial Cells

2005 • 107 citations

Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor‐α in human aortic smooth muscle and embryonic kidney cells

2006 • 97 citations

A Human scFv Antibody against TRAIL Receptor 2 Induces Autophagic Cell Death in Both TRAIL-Sensitive and TRAIL-Resistant Cancer Cells

2007 • 95 citations

Lipid Rafts and Oxidative Stress–Induced Cell Death

2007 • 87 citations

The p65/RelA Subunit of NF-κB Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor

2002 • 82 citations

Redox Regulation of Apoptosis by Members of the TNF Superfamily

2005 • 76 citations

Modulation of TNF-α-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors

1992 • 76 citations

Fas-stimulated generation of reactive oxygen species or exogenous oxidative stress sensitize cells to Fas-mediated apoptosis

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In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines

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Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-α and granulocyte colony stimulating factor

1992 • 59 citations

The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells

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Implication of cytosolic phospholipase A2 (cPLA2) in the regulation of human synoviocyte NADPH oxidase (Nox2) activity

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Lack of effect of pertussis toxin on TNF-α-induced formation of reactive oxygen intermediates by human neutrophils

1989 • 13 citations