Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Signaling to NF-κB

2004 • 3,768 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

2003 • 2,642 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

2001 • 2,024 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

The anti-angiogenic basis of metronomic chemotherapy

2004 • 1,363 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Intrinsic tumour suppression

2004 • 1,267 citations

The proteasome: a suitable antineoplastic target

2004 • 1,189 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

1996 • 1,125 citations

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

1997 • 1,045 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 • 946 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

Phase I Trial of the Proteasome Inhibitor PS-341 in Patients With Refractory Hematologic Malignancies

2002 • 771 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

1998 • 721 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Transcriptional Cross Talk between NF-κB and p53

1999 • 590 citations

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

2001 • 544 citations

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

2003 • 505 citations

Sulindac Inhibits Activation of the NF-κB Pathway

1999 • 490 citations

Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-κB Activation in Human Endothelial Cells

2004 • 485 citations

Treatment of multiple myeloma

2003 • 474 citations

Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

2003 • 472 citations

Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase.

2000 • 445 citations

Preferential induction of apoptosis for primary human leukemic stem cells

2002 • 424 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells

2003 • 409 citations

Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

2004 • 382 citations

The IκB/NF-κB system: a key determinant of mucosal inflammation and protection

2000 • 377 citations

Andrographolide Attenuates Inflammation by Inhibition of NF-κB Activation through Covalent Modification of Reduced Cysteine 62 of p50

2004 • 355 citations

Tumour necrosis factor α: a potential target for the therapy of solid tumours

2003 • 353 citations

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

2004 • 352 citations

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1996 • 342 citations

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1996 • 340 citations

Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?

2003 • 340 citations

Cyclin D1 and human neoplasia

1998 • 336 citations

Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

2004 • 312 citations

p53 stabilization is decreased upon NFκB activation

2002 • 311 citations

HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

2002 • 310 citations

Resveratrol blocks interleukin-1β–induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

2003 • 305 citations

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

1997 • 300 citations

Constitutive Activation of NF-κB in Primary Adult T-Cell Leukemia Cells

1999 • 292 citations

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide

2000 • 290 citations

Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β

2000 • 285 citations

Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

2004 • 284 citations

Bay 11-7082 inhibits transcription factor NF-kappa B and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

2002 • 276 citations

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.

1995 • 276 citations

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

2003 • 276 citations

Activation of NF-κB by Antineoplastic Agents

1997 • 271 citations

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling

2004 • 270 citations

26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

2001 • 263 citations

Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

1998 • 257 citations

Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis

2004 • 253 citations

Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice

2004 • 247 citations

Novel IKK inhibitors: β-carbolines

2003 • 239 citations

Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells

2003 • 238 citations

Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB

2004 • 237 citations

Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

2001 • 228 citations

Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice.

2000 • 223 citations

Chemosensitization of Pancreatic Cancer by Inhibition of the 26S Proteasome

2001 • 215 citations

Inhibition of NFκB Increases the Efficacy of Cisplatin in in Vitro and in Vivo Ovarian Cancer Models

2004 • 214 citations

Caffeic Acid Phenethyl Ester Induces Apoptosis by Inhibition of NFκB and Activation of Fas in Human Breast Cancer MCF-7 Cells

2004 • 214 citations

Activation of Transcription Factor NF-κB Requires ELKS, an IκB Kinase Regulatory Subunit

2004 • 213 citations

Inhibition of Tumor Necrosis Factor-α-induced Nuclear Translocation and Activation of NF-κB by Dehydroxymethylepoxyquinomicin

2002 • 207 citations

The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells.

2002 • 190 citations

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

2004 • 180 citations

Ineffectiveness of Histone Deacetylase Inhibitors to Induce Apoptosis Involves the Transcriptional Activation of NF-κB through the Akt Pathway

2003 • 179 citations

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis

2004 • 178 citations

Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells.

1999 • 172 citations

Nuclear Factor-inducing Kinase Plays a Crucial Role in Osteopontin-induced MAPK/IκBα Kinase-dependent Nuclear Factor κB-mediated Promatrix Metalloproteinase-9 Activation

2004 • 172 citations

Flavopiridol Inhibits NF-κB Activation Induced by Various Carcinogens and Inflammatory Agents through Inhibition of IκBα Kinase and p65 Phosphorylation

2004 • 164 citations

Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C

2000 • 163 citations

Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation.

2000 • 160 citations

IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy

2003 • 157 citations

An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.

2003 • 154 citations

Constitutive activation of nuclear factor-κB prevents TRAIL-induced apoptosis in renal cancer cells

2001 • 148 citations

Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma

2002 • 146 citations

Dysregulated cyclin D1 expression early in head and neck tumorigenesis: in vivo evidence for an association with subsequent gene amplification

1998 • 136 citations

Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells.

2001 • 133 citations

Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells

2004 • 128 citations

Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells

1996 • 123 citations

Lycopene suppresses the lipopolysaccharide‐induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen‐activated protein kinases and nuclear factor‐κB

2004 • 122 citations

Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol

2002 • 121 citations

Matrix Metalloproteinase 9 Expression Is Induced by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal Activation Regions 1 and 2

1999 • 121 citations

Apoptosis-Inducing Effect of Chemotherapeutic Agents Is Potentiated by Soy Isoflavone Genistein, a Natural Inhibitor of NF-??B in BxPC-3 Pancreatic Cancer Cell Line

2004 • 118 citations

Interferon-α sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-κB inactivation

2003 • 117 citations

A Phase I study of CHS 828 in patients with solid tumor malignancy.

2002 • 116 citations

Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells

2004 • 114 citations

Suppression of hormone-refractory prostate cancer by a novel nuclear factor kappaB inhibitor in nude mice.

2003 • 110 citations

Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-κB inhibition

2000 • 109 citations

Inhibition of NF-κB Activation by Panepoxydone

1996 • 109 citations

Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors

2004 • 109 citations

Proteasome Inhibition Sensitizes Non–Small-Cell Lung Cancer to Gemcitabine-Induced Apoptosis

2004 • 108 citations

HIV-1 Protease Inhibitor, Ritonavir

2004 • 107 citations

NF-κB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors

2003 • 100 citations

Cell Stress and MEKK1-mediated c-Jun Activation Modulate NFκB Activity and Cell Viability

2002 • 98 citations

Inhibition of AKT abrogates chemotherapy- induced NF-κB survival mechanisms: implications for therapy in pancreatic cancer1

2004 • 98 citations

Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

2003 • 93 citations

Enhanced Chemosensitivity to Irinotecan by RNA Interference-Mediated Down-Regulation of the Nuclear Factor-κB p65 Subunit

2004 • 92 citations

Potentiation of Tumor Necrosis Factor-Induced NF-κB Activation by Deacetylase Inhibitors Is Associated with a Delayed Cytoplasmic Reappearance of IκBα

2003 • 88 citations

Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.

2002 • 80 citations

Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.

2003 • 79 citations

Combined proteasome and histone deacetylase inhibition in non–small cell lung cancer

2004 • 77 citations

The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

2001 • 74 citations

IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.

1998 • 71 citations

The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.

2002 • 68 citations

Inhibitory effect of growth hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes.

1997 • 63 citations

Human Chorionic Gonadotropin Decreases Proliferation and Invasion of Breast Cancer MCF-7 Cells by Inhibiting NF-κB and AP-1 Activation

2004 • 61 citations

IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis

1998 • 60 citations

Human breast milk suppresses the transcriptional regulation of IL-1β-induced NF-κB signaling in human intestinal cells

2004 • 59 citations

Cycloepoxydon, 1-Hydroxy-2 hydroxymethyl-3-pent-1-enylbenzene and 1-Hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene, New Inhibitors of Eukaryotic Signal Transduction.

1998 • 58 citations

Combined histone deacetylase and NF-κB inhibition sensitizes non-small cell lung cancer to cell death

2004 • 56 citations

Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)–mediated signaling pathway

2004 • 56 citations

Involvement of Nuclear Factor κB in c-Myc Induction by Tubulin Polymerization Inhibitors

2001 • 55 citations

Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance.

1998 • 55 citations

NF-κB Sites Function as Positive Regulators of Expression of the Translocated c-myc Allele in Burkitt's Lymphoma

1994 • 54 citations

Contribution of Disruption of the Nuclear Factor-κB Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol

2004 • 52 citations

Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression

2002 • 45 citations

Anticancer agent CHS 828 suppresses nuclear factor‐κB activity in cancer cells through downregulation of IKK activity

2004 • 44 citations

Interleukin‐4 and interleukin‐10 modulate nuclear factor κB activity and nitric oxide synthase‐2 expression in Theiler's virus‐infected brain astrocytes

2002 • 38 citations

α-MSH inhibits inflammatory signalling in Schwann cells

2004 • 35 citations

NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.

1994 • 30 citations

Potentiation of Tumor Necrosis Factor-Induced NF-κB Activation by Deacetylase Inhibitors Is Associated with a Delayed Cytoplasmic Reappearance of IκBα

2004 • 27 citations

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro–from cytotoxic synergy to complete inhibition of apoptosis

2002 • 20 citations

Opposite effects of antimicrotubule agents on c-myc oncogene expression depending on the cell lines used

2000 • 19 citations

Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-κB activity

2003 • 14 citations