Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

2000 • 1,337 citations

CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

2003 • 932 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Identification of the familial cylindromatosis tumour-suppressor gene

2000 • 654 citations

Tumor necrosis factor receptor-associated factors (TRAFs)

2001 • 632 citations

All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction

2002 • 594 citations

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

2000 • 560 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

2002 • 393 citations

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

2000 • 384 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

2002 • 288 citations

Deubiquitinating Enzymes: A New Class of Biological Regulators

1998 • 266 citations

NF-κB activity in transgenic mice: developmental regulation and tissue specificity

1996 • 229 citations

Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices

2001 • 214 citations

Deubiquitinating Enzymes: Their Diversity and Emerging Roles

1999 • 179 citations

Tumor Necrosis Factor (TNF)-induced Germinal Center Kinase-related (GCKR) and Stress-activated Protein Kinase (SAPK) Activation Depends upon the E2/E3 Complex Ubc13-Uev1A/TNF Receptor-associated Factor 2 (TRAF2)

2003 • 172 citations

Interrelated Effects of Tumor Necrosis Factor and Interleukin 1 on Cell Viability

1988 • 43 citations

Dermal eccrine cylindromatosis.

1994 • 41 citations

Molecular cloning of a novel oncogene generated by DNA recombination during transfection.

1988 • 26 citations