Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition

Mitochondria and Apoptosis

1998 • 8,909 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 • 887 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Mitochondrial control of apoptosis: the role of cytochrome c

1998 • 751 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

1999 • 664 citations

Opening of the Mitochondrial Permeability Transition Pore Causes Depletion of Mitochondrial and Cytosolic NAD+and Is a Causative Event in the Death of Myocytes in Postischemic Reperfusion of the Heart

2001 • 658 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

2000 • 564 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Mitochondria are morphologically and functionally heterogeneous within cells

2002 • 551 citations

Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.

1996 • 511 citations

THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY

1996 • 486 citations

P2X₇Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes

2003 • 479 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cells

2000 • 450 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons

2003 • 327 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress

2003 • 303 citations

Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism

2001 • 244 citations

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

2000 • 216 citations

Functional Heterogeneity of an Isolated Mitochondrial Population Revealed by Cytofluorometric Analysis at the Single Organelle Level

1996 • 212 citations

Structure and function of poly(ADP-ribose) polymerase

1994 • 206 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes

2003 • 196 citations

Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat

1998 • 190 citations

Mitochondrial permeability transition in acute neurodegeneration

2002 • 180 citations

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca²⁺ and Oxidant Stress

1996 • 163 citations

Pathophysiological relevance of mitochondria in NAD⁺ metabolism

2001 • 160 citations

Potential role of calcineurin for brain ischemia and traumatic injury

1999 • 128 citations

Evidence of a role for cyclic ADP‐ribose in calcium signalling and neurotransmitter release in cultured astrocytes

2001 • 128 citations

Tricarboxylic Acid Cycle Substrates Prevent PARP-Mediated Death of Neurons and Astrocytes

2002 • 127 citations

A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis

2001 • 113 citations

Cyclosporin A and its nonimmunosuppressive analogue N‐Me‐Val‐4‐cyclosporin A mitigate glucose/oxygen deprivation‐induced damage to rat cultured hippocampal neurons

1999 • 113 citations

Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment

1993 • 110 citations

Imaging the mitochondrial permeability transition pore in intact cells

1998 • 98 citations

Astrocytes protect neurons from neurotoxic injury by serum glutamate

1998 • 89 citations

Cyclosporin A Enhances Survival, Ameliorates Brain Damage, and Prevents Secondary Mitochondrial Dysfunction after a 30-Minute Period of Transient Cerebral Ischemia

2000 • 77 citations

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

2002 • 77 citations

Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia

1999 • 61 citations

Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

2001 • 50 citations

Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

2002 • 44 citations

Analysis of ADP-ribose polymer sizes in intact cells.

2001 • 16 citations