Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Proteases to die for

1998 • 1,241 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1999 • 850 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

TNF receptor subtype signalling: Differences and cellular consequences

2002 • 603 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

2003 • 494 citations

Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling

2002 • 470 citations

A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses

2003 • 447 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

The CD95 Type I/Type II model

2003 • 415 citations

The essential role of MEKK3 in TNF-induced NF-κB activation

2001 • 389 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

2003 • 253 citations

FADD Is Required for DR4- and DR5-mediated Apoptosis

2000 • 229 citations

Reactive oxygen intermediates in TNF signaling

2002 • 228 citations

The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase

2000 • 225 citations

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

2001 • 202 citations

Reactive Oxygen Species Are Downstream Products of TRAF-mediated Signal Transduction

2001 • 196 citations

The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

2003 • 128 citations

Constitutive expression of NF-κB is a characteristic feature of mycosis fungoides: Implications for apoptosis resistance and pathogenesis

2000 • 125 citations

Overexpression of manganese-containing superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor alpha and/or hyperthermia.

1997 • 122 citations

The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase

2003 • 97 citations

The Oxidative Metabolism of Glutamine

1996 • 92 citations

TRAF2 Exerts Its Antiapoptotic Effect by Regulating the Expression of Krüppel-Like Factor LKLF

2003 • 34 citations