Is NF-κB a good target for cancer therapy? Hopes and pitfalls

The Hallmarks of Cancer

2000 • 27,569 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

The Genomic Landscapes of Human Breast and Colorectal Cancers

2007 • 2,716 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

A cytokine-mediated link between innate immunity, inflammation, and cancer

2007 • 1,867 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

2001 • 1,520 citations

The IKK NF-κB system: a treasure trove for drug development

2004 • 1,340 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Multiple Myeloma

2004 • 1,219 citations

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

2007 • 1,166 citations

Characterizing the cancer genome in lung adenocarcinoma

2007 • 1,110 citations

Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

2006 • 1,044 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

2007 • 1,028 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

2007 • 974 citations

Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma

2007 • 925 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

2005 • 838 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

2005 • 725 citations

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

2003 • 721 citations

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

2003 • 678 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

2006 • 648 citations

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

2005 • 624 citations

Herceptin acts as an anti-angiogenic cocktail

2002 • 608 citations

IAPs, RINGs and ubiquitylation

2005 • 591 citations

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1996 • 582 citations

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

2008 • 580 citations

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

2007 • 580 citations

The inhibitors of apoptosis (IAPs) as cancer targets

2007 • 546 citations

Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity

2001 • 477 citations

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

2002 • 453 citations

Representational Oligonucleotide Microarray Analysis: A High-Resolution Method to Detect Genome Copy Number Variation

2003 • 452 citations

Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation

2004 • 449 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

2004 • 413 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Current insights into the regulation of programmed cell death by NF-κB

2006 • 399 citations

The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: therapeutic applications

2001 • 398 citations

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib

2006 • 398 citations

Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications

2006 • 394 citations

Two Pathways to NF-κB

2002 • 383 citations

From signatures to models: understanding cancer using microarrays

2005 • 383 citations

Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

2002 • 382 citations

TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology

2004 • 365 citations

The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development

2006 • 340 citations

B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation

2004 • 249 citations

STI571 (Gleevec™) as a paradigm for cancer therapy

2002 • 244 citations

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

2008 • 232 citations

Receptor-Specific Signaling for Both the Alternative and the Canonical NF-κB Activation Pathways by NF-κB-Inducing Kinase

2004 • 231 citations

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

2008 • 215 citations

Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

2005 • 188 citations

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

2005 • 185 citations

Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

2003 • 183 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Rescue of TRAF3-null mice by p100 NF-κB deficiency

2006 • 164 citations

New Drugs for Myeloma

2007 • 163 citations

Analysis of expression of nuclear factor κB (NF‐κB) in multiple myeloma: downregulation of NF‐κB induces apoptosis

2001 • 162 citations

RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

2003 • 147 citations

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

2006 • 142 citations

MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

2006 • 128 citations

Dying for NF-κB? Control of cell death by transcriptional regulation of the apoptotic machinery

2003 • 120 citations

Global action against cancer

2003 • 119 citations

Phase 2 study of arsenic trioxide in patients with relapsed or refractory multiple myeloma

2004 • 114 citations

The Anti-Death Machinery in IKK/NF-κB Signaling

2005 • 102 citations

The relationship between quality of response and clinical benefit for patients treated on the bortezomib arm of the international, randomized, phase 3 APEX trial in relapsed multiple myeloma

2008 • 102 citations

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

2008 • 101 citations

Nuclear factor B as a target for new drug development in myeloid malignancies

2007 • 100 citations

Specificity of TRAF3 in Its Negative Regulation of the Noncanonical NF-κB Pathway

2006 • 99 citations

Cytokines and signal transduction

2005 • 96 citations

Interruption of the NF-κB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells

2003 • 93 citations

The malignant clone and the bone-marrow environment

2007 • 89 citations

Bone marrow endothelial cells increase the invasiveness of human multiple myeloma cells through upregulation of MMP-9: evidence for a role of hepatocyte growth factor

2004 • 78 citations

Molecular diagnosis of lymphoid malignancies by gene expression profiling

2002 • 68 citations

Growth Inhibition of Multiple Myeloma Cells by a Novel IκB Kinase Inhibitor

2005 • 67 citations

Disease-specific genomic analysis: identifying the signature of pathologic biology

2007 • 57 citations

Immunodeficiency of alymphoplasia mice (aly/aly)in vivo: structural defect of secondary lymphoid organs and functional B cell defect

2000 • 54 citations

Targeting NF‐κB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth

2007 • 54 citations

Deregulated NF-κB activity in haematological malignancies

2006 • 51 citations

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

2006 • 45 citations

Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)

2007 • 38 citations

Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas

2007 • 34 citations

State of the art therapy in multiple myeloma and future perspectives

2006 • 33 citations

A supervised approach for identifying discriminating genotype patterns and its application to breast cancer data

2007 • 26 citations

Targeting Loss-of-Function Mutations in Tumor-Suppressor Genes as a Strategy for Development of Cancer Therapeutic Agents

2006 • 25 citations