TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Tumor necrosis factor signaling

2003 • 2,262 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1999 • 850 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

2005 • 752 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells

2003 • 578 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

NF- B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

2003 • 494 citations

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation

2003 • 441 citations

Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation

2004 • 407 citations

Chronic granulomatous disease

2003 • 377 citations

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

2003 • 366 citations

Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK

2006 • 316 citations

A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

2006 • 299 citations

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

2003 • 274 citations

Nox1-dependent Reactive Oxygen Generation Is Regulated by Rac1

2006 • 263 citations

Involvement of Rac1 in Activation of Multicomponent Nox1- and Nox3-Based NADPH Oxidases

2006 • 221 citations

PKCζ Regulates TNF-α–Induced Activation of NADPH Oxidase in Endothelial Cells

2002 • 220 citations

NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

2004 • 203 citations

TNF-α Induces Phosphorylation of p47phox in Human Neutrophils: Partial Phosphorylation of p47phox Is a Common Event of Priming of Human Neutrophils by TNF-α and Granulocyte-Macrophage Colony-Stimulating Factor

2003 • 158 citations

Direct Involvement of the Small GTPase Rac in Activation of the Superoxide-producing NADPH Oxidase Nox1

2006 • 132 citations

gp91^phox Contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells

2003 • 75 citations

Biosynthesis of Flavocytochrome b 558

1999 • 74 citations

Null Mutation of gp91^phox Reduces Muscle Membrane Lysis During Muscle Inflammation in Mice

2003 • 69 citations

Review

2003 • 57 citations

Production of singlet oxygen by eosinophils activated in vitro by C5a and leukotriene B4

1999 • 21 citations