Regulation of Tumor Necrosis Factor-Induced, Mitochondria- and Reactive Oxygen Species-Dependent Cell Death by the Electron Flux through the Electron Transport Chain Complex I

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

Importance of Glucose-6-phosphate Dehydrogenase Activity for Cell Growth

1998 • 511 citations

The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.

1984 • 395 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

1998 • 317 citations

The Yeast Copper/Zinc Superoxide Dismutase and the Pentose Phosphate Pathway Play Overlapping Roles in Oxidative Stress Protection

1996 • 217 citations

Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress

1997 • 155 citations

[132] Fluorometric analyses of riboflavin and its coenzymes

1971 • 154 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity

1993 • 97 citations

The Oxidative Metabolism of Glutamine

1996 • 92 citations

Stimulation of RNA Synthesis in L-929 Cells by Rabbit Tumor Necrosis Factor

1979 • 81 citations

Metabolic Oxidative Stress-induced HSP70 Gene Expression Is Mediated through SAPK Pathway

1998 • 67 citations

Flow‐cytometric monitoring of intracellular flavins simultaneously with NAD(P)H levels

1983 • 64 citations

Bioenergetics of tumor cells: Glutamine metabolism in tumor cell mitochondria

1987 • 54 citations

Flavoproteins of mitochondrial fatty acid oxidation.

1967 • 47 citations

Flow cytometric analysis of cellular endogenous fluorescence simultaneously with emission from exogenous fluorochromes, light scatter and absorption

1981 • 44 citations

The effect of tumour bearing on skeletal muscle glutamine metabolism

1991 • 39 citations

Damage to Mitochondrial Respiration Chain Is Related to Phospholipase A2 Activation Caused by Tumor Necrosis Factor

1992 • 17 citations