The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Biochemistry and molecular cell biology of diabetic complications

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Role of AMP-activated protein kinase in mechanism of metformin action

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THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

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Insulin signalling and the regulation of glucose and lipid metabolism

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Cellular mechanisms of insulin resistance

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The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

2002 • 2,244 citations

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 • 2,035 citations

Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

2003 • 1,964 citations

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1999 • 1,900 citations

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

2003 • 1,893 citations

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function

1993 • 1,391 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

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Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

2000 • 1,178 citations

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1992 • 1,156 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

1985 • 1,147 citations

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,135 citations

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

2000 • 1,096 citations

Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

2001 • 1,082 citations

Exercise, Glucose Transport, and Insulin Sensitivity

1998 • 1,066 citations

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

2002 • 1,027 citations

Mechanism by which metformin reduces glucose production in type 2 diabetes.

2000 • 1,017 citations

Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

2003 • 1,003 citations

Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach

1989 • 999 citations

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

2003 • 989 citations

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

1991 • 980 citations

Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

2001 • 945 citations

Radicals and oxidative stress in diabetes

2000 • 933 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Protein phosphatase 1 – targeted in many directions

2002 • 911 citations

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

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Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

1998 • 843 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

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Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

2002 • 791 citations

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

2003 • 758 citations

Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

1993 • 737 citations

Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity

2002 • 735 citations

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

2000 • 733 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome

2003 • 672 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

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Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans

1988 • 627 citations

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

β-cells in type II diabetes mellitus

1991 • 582 citations

Renal Na⁺-glucose cotransporters

2001 • 558 citations

A Subtype of Diabetes Mellitus Associated with a Mutation of Mitochondrial DNA

1994 • 557 citations

Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation

1998 • 556 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

2003 • 512 citations

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

1993 • 510 citations

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

2003 • 498 citations

Novel concepts in insulin regulation of hepatic gluconeogenesis

2003 • 494 citations

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

1995 • 478 citations

Structure and function of mammalian facilitative sugar transporters.

1993 • 465 citations

Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.

1998 • 450 citations

Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

2000 • 435 citations

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1997 • 419 citations

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

1996 • 410 citations

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators

2002 • 406 citations

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM

1996 • 400 citations

Lipid overload and overflow: metabolic trauma and the metabolic syndrome

2003 • 390 citations

Linkage of type 2 diabetes to the glucokinase gene

1992 • 386 citations

Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus¹

2000 • 373 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier

1998 • 358 citations

Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

2002 • 357 citations

Hexokinases

2006 • 353 citations

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

2000 • 344 citations

Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

1996 • 330 citations

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

1998 • 324 citations

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

1990 • 322 citations

Risk factors for Type 2 (non-insulin-dependent) diabetes mellitus. Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913

1988 • 319 citations

Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome

1997 • 316 citations

Hexosamines and Insulin Resistance

1996 • 316 citations

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

1995 • 316 citations

Role of the glucosamine pathway in fat-induced insulin resistance.

1997 • 315 citations

Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.

1991 • 311 citations

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus.

1992 • 301 citations

Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

2001 • 296 citations

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

2002 • 294 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Insulin Resistance, Hyperinsulinemia, Hypertriglyceridemia, and Hypertension: Parallels Between Human Disease and Rodent Models

1991 • 286 citations

Evolution and regulatory role of the hexokinases

1998 • 285 citations

Mitochondria and Diabetes: Genetic, Biochemical, and Clinical Implications of the Cellular Energy Circuit

1996 • 282 citations

Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)

2002 • 279 citations

Lactate production in adipose tissue; a regulated function with extra‐adipose implications

1992 • 278 citations

Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption

1996 • 269 citations

Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

2003 • 268 citations

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

2001 • 268 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Control of glycogen synthase by hierarchal protein phosphorylation

1990 • 266 citations

Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus

2000 • 262 citations

Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue

2001 • 252 citations

A new look at the biogenesis of glycogen

1995 • 250 citations

Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin

2002 • 249 citations

Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia.

1988 • 249 citations

Glucosamine-6-phosphate synthase—the multi-facets enzyme

2002 • 244 citations

Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology

1997 • 241 citations

Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.

1995 • 239 citations

The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects

1994 • 231 citations

GLUTX1, a Novel Mammalian Glucose Transporter Expressed in the Central Nervous System and Insulin-sensitive Tissues

2000 • 230 citations

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

1998 • 227 citations

Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.

1992 • 225 citations

Identification of a novel glucose transporter-like protein—GLUT-12

2002 • 217 citations

Lactate and glucose interactions during rest and exercise in men: effect of exogenous lactate infusion

2002 • 213 citations

Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)

2002 • 212 citations

Exercise and Diabetes Mellitus

1979 • 212 citations

Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus

1998 • 206 citations

Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.

1990 • 204 citations

Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism.

1990 • 199 citations

Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity.

2000 • 198 citations

Glucose fatty acid interactions and the regulation of glucose disposal

1994 • 195 citations

Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle

1996 • 191 citations

Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle

2002 • 191 citations

Perturbation of Fuel Homeostasis Caused by Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Liver of Normal Rats

1998 • 189 citations

Changes in Sodium or Glucose Filtration Rate Modulate Expression of Glucose Transporters in Renal Proximal Tubular Cells of Rat

2001 • 187 citations

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

1993 • 181 citations

Starvation Increases the Amount of Pyruvate Dehydrogenase Kinase in Several Mammalian Tissues

2000 • 180 citations

Association between Polymorphism of the Glycogen Synthase Gene and Non-Insulin-Dependent Diabetes Mellitus

1993 • 179 citations

Regulation of the citric acid cycle in mammalian systems

1980 • 171 citations

Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway

2002 • 170 citations

The Second Activating Glucokinase Mutation (A456V)

2002 • 168 citations

Importance of Glucose Per Se to Intravenous Glucose Tolerance: Comparison of the Minimal-Model Prediction with Direct Measurements

1985 • 166 citations

Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat

1977 • 165 citations

Mechanisms modifying glucose oxidation in diabetes mellitus

1994 • 165 citations

Glycogen synthesis from lactate in the three types of skeletal muscle.

1979 • 165 citations

Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway

2002 • 164 citations

Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.

1993 • 164 citations

Rosiglitazone but Not Metformin Enhances Insulin- and Exercise-Stimulated Skeletal Muscle Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes

2002 • 164 citations

Glucose transporter gene expression in early mouse embryos

1991 • 163 citations

The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome

2001 • 160 citations

Sequence and Functional Analysis of GLUT10: A Glucose Transporter in the Type 2 Diabetes-Linked Region of Chromosome 20q12–13.1

2001 • 157 citations

Pre-Exposure to Glucosamine Induces Insulin Resistance of Glucose Transport and Glycogen Synthesis in Isolated Rat Skeletal Muscles: Study of Mechanisms in Muscle and in Rat-1 Fibroblasts Overexpressing the Human Insulin Receptor

1993 • 157 citations

Endocrine pancreas plasticity under physiological and pathological conditions.

2001 • 155 citations

Molecular Cloning of a Novel Member of the GLUT Family of Transporters, SLC2A10 (GLUT10), Localized on Chromosome 20q13.1: A Candidate Gene for NIDDM Susceptibility

2001 • 155 citations

In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.

1995 • 154 citations

Glycogen storage diseases.

2003 • 154 citations

Digenic inheritance of severe insulin resistance in a human pedigree

2002 • 150 citations

Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes

1993 • 149 citations

Effect of Physiological Hyperinsulinemia on Gluconeogenesis in Nondiabetic Subjects and in Type 2 Diabetic Patients

2001 • 149 citations

Effects of glucosamine infusion on insulin secretion and insulin action in humans.

2000 • 147 citations

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1991 • 147 citations

Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation

1991 • 143 citations

Mechanism of troglitazone action in type 2 diabetes.

2000 • 143 citations

Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.

1998 • 143 citations

Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.

1990 • 142 citations

Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.

2000 • 141 citations

Troglitazone Induces GLUT4 Translocation in L6 Myotubes

2001 • 141 citations

A Major Predisposition Locus for Severe Obesity, at 4p15-p14

2002 • 140 citations

Impaired Activation of Glycogen Synthase in People at Increased Risk for Developing NIDDM

1992 • 139 citations

Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle

1988 • 133 citations

Glucokinase Regulatory Protein May Interact With Glucokinase in the Hepatocyte Nucleus

1997 • 133 citations

Liver Glucokinase: Decreased Activity in Patients with Type II Diabetes

1995 • 131 citations

Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0.

1998 • 131 citations

Inborn errors of the Krebs cycle: a group of unusual mitochondrial diseases in human

1997 • 131 citations

Relationship between the plasma glucose level and glucose uptake in the conscious dog

1978 • 129 citations

Increased Glutamine:Fructose-6-Phosphate Amidotransferase Activity in Skeletal Muscle of Patients With NIDDM

1996 • 127 citations

Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy.

1991 • 124 citations

Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle.

1990 • 123 citations

Glucokinase Gene Structure: Functional Implications of Molecular Genetic Studies

1990 • 123 citations

Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin

1996 • 122 citations

Isolation of a cDNA for the Catalytic Subunit of Rat Liver Glucose-6-Phosphatase: Regulation of Gene Expression in FAO Hepatoma Cells by Insulin, Dexamethasone and cAMP

1994 • 122 citations

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.

1998 • 121 citations

Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation

1996 • 118 citations

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes.

1984 • 117 citations

Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle

2001 • 115 citations

Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM

1994 • 115 citations

Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians

2002 • 114 citations

Insulin Downregulates Pyruvate Dehydrogenase Kinase (PDK) mRNA: Potential Mechanism Contributing to Increased Lipid Oxidation in Insulin-Resistant Subjects

1998 • 114 citations

Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells

2001 • 110 citations

Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle

1996 • 110 citations

Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle.

1996 • 107 citations

Expression of Glutamine:Fructose-6-Phosphate Amidotransferase in Human Tissues: Evidence for High Variability and Distinct Regulation in Diabetes

1998 • 107 citations

Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.

1986 • 107 citations

Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo

1999 • 106 citations

Effects of Metformin on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver

1997 • 105 citations

Association of Metformin's Effect to Increase Insulin-Stimulated Glucose Transport With Potentiation of Insulin-Induced Translocation of Glucose Transporters From Intracellular Pool to Plasma Membrane in Rat Adipocytes

1991 • 105 citations

Short-term regulation of insulin gene transcription by glucose

1998 • 104 citations

Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet

2002 • 104 citations

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations

1996 • 103 citations

Regulation of Glycogen Synthase by Glucose and Glycogen

2003 • 103 citations

The Sulfonylurea Drug, Glimepiride, Stimulates Glucose Transport, Glucose Transporter Translocation, and Dephosphorylation in Insulin-Resistant Rat Adipocytes In Vitro

1993 • 103 citations

Troglitazone Effects on Gene Expression in Human Skeletal Muscle of Type II Diabetes Involve Up-Regulation of Peroxisome Proliferator-Activated Receptor-γ1

1998 • 103 citations

The pancreatic β-cell glucose sensor

1994 • 103 citations

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

2000 • 102 citations

Adipocytes Exhibit Abnormal Subcellular Distribution and Translocation of Vesicles Containing Glucose Transporter 4 and Insulin-Regulated Aminopeptidase in Type 2 Diabetes Mellitus: Implications Regarding Defects in Vesicle Trafficking

2001 • 102 citations

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression

2000 • 101 citations

Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and mice

1995 • 100 citations

Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

1997 • 99 citations

Glucose Autoregulates Its Uptake in Skeletal Muscle

2003 • 97 citations

Non-Insulin-Mediated Glucose Disappearance in Subjects With IDDM: Discordance Between Experimental Results and Minimal Model Analysis

1994 • 95 citations

Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.

1995 • 94 citations

Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components.

1997 • 92 citations

Impaired Basal Glucose Effectiveness in NIDDM: Contribution of Defects in Glucose Disappearance and Production, Measured Using an Optimized Minimal Model Independent Protocol

1997 • 90 citations

Mutations in the Liver Glycogen Phosphorylase Gene (PYGL) Underlying Glycogenosis Type VI (Hers Disease)

1998 • 89 citations

Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal-model method

1996 • 88 citations

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

1998 • 85 citations

Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle

2001 • 84 citations

Effects of Free Fatty Acids and Glycerol on Splanchnic Glucose Metabolism and Insulin Extraction in Nondiabetic Humans

2002 • 84 citations

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin

1995 • 83 citations

Regulation of hexokinase II activity and expression in human muscle by moderate exercise

1998 • 83 citations

Thrombin Stimulates Glucose Transport in Human Platelets via the Translocation of the Glucose Transporter GLUT-3 from α-Granules to the Cell Surface

1997 • 83 citations

Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals.

1996 • 82 citations

Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance

2003 • 82 citations

Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

2000 • 81 citations

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

1997 • 81 citations

Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin.

1996 • 80 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 79 citations

Evidence that GLUT-2 mRNA and protein concentrations are decreased by hyperinsulinaemia and increased by hyperglycaemia in liver of diabetic rats

1992 • 79 citations

Evidence that glucose transport is rate-limiting for in vivo glucose uptake

1992 • 79 citations

Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells

2001 • 77 citations

Overexpression of Hexokinase II in Transgenic Mice

1996 • 76 citations

Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle.

1996 • 75 citations

Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets.

1992 • 73 citations

Hepatic Glycogen Synthesis Is Highly Sensitive to Phosphorylase Activity

2001 • 73 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 68 citations

Glucosamine Inhibits Glucokinase In Vitro and Produces a Glucose-Specific Impairment of In Vivo Insulin Secretion in Rats

1994 • 66 citations

Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB

2001 • 65 citations

Effect of dietary energy restriction on glucose production and substrate utilization in type 2 diabetes.

2000 • 65 citations

Dysoxia and lactate

1999 • 64 citations

Hexosamines Regulate Leptin Production in Human Subcutaneous Adipocytes¹

2000 • 64 citations

Novel targets and therapeutic strategies for type 2 diabetes

2003 • 64 citations

Hexokinase II-deficient Mice

1999 • 63 citations

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

1999 • 63 citations

Glucosamine-Induced Inhibition of Liver Glucokinase Impairs the Ability of Hyperglycemia to Suppress Endogenous Glucose Production

1996 • 62 citations

Muscle glycogen synthase translocates from the cell nucleus to the cytosol in response to glucose

1997 • 62 citations

Selective Modification of Pyruvate Dehydrogenase Kinase Isoform Expression in Rat Pancreatic Islets Elicited by Starvation and Activation of Peroxisome Proliferator–Activated Receptor-α

2001 • 61 citations

Impaired Insulin-Stimulated Expression of the Glycogen Synthase Gene in Skeletal Muscle of Type 2 Diabetic Patients Is Acquired Rather Than Inherited1

2000 • 61 citations

Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency

1998 • 60 citations

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

2002 • 59 citations

Stimulation of glucose uptake and increased plasma membrane content of glucose transporters in L6 skeletal muscle cells by the sulfonylureas gliclazide and glyburide.

1995 • 59 citations

Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme.

1993 • 59 citations

Hexokinase Isozyme Distribution in Human Skeletal Muscle

2001 • 57 citations

Lactate infusion in anesthetized rats produces insulin resistance in heart and skeletal muscles

1997 • 57 citations

Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress

1999 • 57 citations

Therapeutic Potential of the Mammalian Pyruvate Dehydrogenase Kinases in the Prevention of Hyperglycaemia

2002 • 56 citations

Localization of the type III isozyme of hexokinase at the nuclear periphery

1992 • 54 citations

Regulation of Glycogen Synthase by Glucose, Glucosamine, and Glutamine:Fructose-6-Phosphate Amidotransferase

1995 • 53 citations

Genetics of NIDDM in France: Studies With 19 Candidate Genes in Affected Sib Pairs

1997 • 52 citations

GNIP, a Novel Protein That Binds and Activates Glycogenin, the Self-glucosylating Initiator of Glycogen Biosynthesis

2002 • 51 citations

Modulation of GLUT1 Intrinsic Activity in Clone 9 Cells by Inhibition of Oxidative Phosphorylation

1995 • 51 citations

The Molecular Basis of Type 1 Glycogen Storage Diseases

2001 • 50 citations

Metabolic and thermogenic effects of lactate infusion in humans

1993 • 49 citations

Human GLUT4/Muscle-Fat Glucose-Transporter Gene: Characterization and Genetic Variation

1992 • 48 citations

Dual Mechanisms for Glucose 6-Phosphate Inhibition of Human Brain Hexokinase

1999 • 47 citations

Hexosamines Regulate Leptin Production in Human Subcutaneous Adipocytes

2000 • 47 citations

Insulin regulation of pyruvate kinase activity in isolated adipocytes. Crucial role of glucose and the hexosamine biosynthesis pathway in the expression of insulin action.

1992 • 46 citations

Interaction of Insulin and Exercise on Glucose Transport in Muscle

1992 • 45 citations

Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine

1997 • 43 citations

Regulation of hexokinase II expression in human skeletal muscle in vivo

2000 • 43 citations

Discordant Effects of Glucosamine on Insulin-stimulated Glucose Metabolism and Phosphatidylinositol 3-Kinase Activity

1999 • 42 citations

Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM

1997 • 40 citations

Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism

1999 • 40 citations

Translocation and Aggregation of Hepatic Glycogen Synthase During the Fasted‐to‐Refed Transition in Rats

1996 • 40 citations

Self-Glucosylation of Glycogenin, the Initiator of Glycogen Biosynthesis, Involves an Inter-subunit Reaction

1999 • 39 citations

Characterization of Human Glycogenin-2, a Self-glucosylating Initiator of Liver Glycogen Metabolism

1998 • 39 citations

Effect of Insulin on Oxidation of Intracellularly and Extracellularly Derived Glucose in Patients With NIDDM: Evidence for Primary Defect in Glucose Transport and/or Phosphorylation but Not Oxidation

1990 • 38 citations

Genetic deficiencies of the glycogen phosphorylase system

1996 • 38 citations

Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells

1991 • 38 citations

Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance.

1997 • 38 citations

Stimulation of GLUT-1 glucose transporter expression in response to hyperosmolarity

2001 • 37 citations

Genotype-Phenotype Correlation in Two Frequent Mutations and Mutation Update in Type III Glycogen Storage Disease

2000 • 35 citations

Fasting Hyperglycemia Normalizes Oxidative and Nonoxidative Pathways of Insulin-Stimulated Glucose Metabolism in Noninsulin-Dependent Diabetes Mellitus*

1990 • 35 citations

Therapeutic Potential of the Mammalian Pyruvate Dehydrogenase Kinases in the Prevention of Hyperglycaemia

2002 • 35 citations

Glycogenin, the primer of glycogen synthesis, binds to actin

1997 • 34 citations

Glucose Metabolism During the Starved-To-Fed Transition in Obese Patients With NIDDM

1994 • 33 citations

Increased Lactate Release per Fat Cell in Normoglycemic First-Degree Relatives of Individuals With Type 2 Diabetes

2001 • 33 citations

Impaired Insulin-Stimulated Expression of the Glycogen Synthase Gene in Skeletal Muscle of Type 2 Diabetic Patients Is Acquired Rather Than Inherited

2000 • 31 citations

Gluconeogenesis in humans with induced hyperlactatemia during low-intensity exercise

2003 • 29 citations

A novel missense mutation in the glycogen branching enzyme gene in a child with myopathy and hepatopathy

1999 • 29 citations

Antagonistic regulation of the glucose/glucose 6-phosphate cycle by insulin and glucagon in cultured hepatocytes

1986 • 29 citations

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland

1997 • 27 citations

Variation in the AU(AT)-Rich Element within the 3′-Untranslated Region ofPPP1R3Is Associated with Variation in Plasma Glucose in Aboriginal Canadians¹

1998 • 27 citations

Exercise Training Increases the Activity of Pyruvate Dehydrogenase Complex in Skeletal Muscle of Diabetic Rats.

2002 • 26 citations

Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.

1992 • 25 citations

The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.

1999 • 24 citations

Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis

2000 • 23 citations

GLUT-1 and GLUT-2 mRNA, protein, and glucose transporter activity in cultured fetal and adult hepatocytes

1994 • 22 citations

Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake

1995 • 22 citations

Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.

2000 • 21 citations

Developmental expression of hexokinase 1 and 3 in rats

1997 • 21 citations

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance

1995 • 20 citations

Interaction of hexokinase with the outer mitochondrial membrane and a hydrophobic matrix.

2001 • 20 citations

Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line

2000 • 19 citations

Structural Domains That Contribute to Substrate Specificity in Facilitated Glucose Transporters Are Distinct from Those Involved in Kinetic Function: Studies with GLUT-1/GLUT-2 Chimeras

1997 • 19 citations

Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise

2003 • 19 citations

Regulation of Mesangial Cell Hexokinase Activity and Expression by Heparin-binding Epidermal Growth Factor-like Growth Factor

2002 • 19 citations

Mutation/Polymorphism Scanning of Glucose-6-Phosphatase Gene Promoter in Noninsulin-Dependent Diabetes Mellitus Patients1

1998 • 17 citations

Asp905Tyr Polymorphism of the Gene for the Skeletal Muscle-Specific Glycogen-Targeting Subunit of Protein Phosphatase 1 in NIDDM

1998 • 17 citations

Derangements of pyruvate dehydrogenase in circulating lymphocytes of NIDDM patients and their healthy offspring

1999 • 15 citations

Effects of infused sodium lactate on glucose and energy metabolism in healthy humans.

1995 • 15 citations

Hepatic sensitivity to insulin: Effects of sulfonylurea drugs

1991 • 15 citations

Gliclazide potentiates suppression of hepatic glucose production in non—insulin-dependent diabetic patients

1996 • 14 citations

Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells

2000 • 14 citations

Overexpression of Glutamine:Fructose-6-Phosphate Amidotransferase in Rat-1 Fibroblasts Enhances Glucose-Mediated Glycogen Accumulation via Suppression of Glycogen Phosphorylase Activity*

2000 • 14 citations

Variation in the AU(AT)-Rich Element within the 3'-Untranslated Region of PPP1R3 Is Associated with Variation in Plasma Glucose in Aboriginal Canadians

1998 • 14 citations

Effect of sulfonylureas on hepatic glycogen metabolism: Activation of glycogen phosphorylase

1989 • 14 citations

PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance‐associated disorders in animal models of type 2 diabetes

2002 • 12 citations

Genetic regulation of malic enzyme activity in the mouse.

1991 • 12 citations

Mechanisms of acute and chronic hypoglycemic action of gliclazide

2000 • 11 citations

GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea

1999 • 10 citations

Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients

1992 • 9 citations

Mutation/Polymorphism Scanning of Glucose-6-Phosphatase Gene Promoter in Noninsulin-Dependent Diabetes Mellitus Patients

1998 • 8 citations

Phosphoglucomutase genetic polymorphism of newborns

2001 • 8 citations

A novel (TA)n polymorphism in the hexokinase II gene: Application to noninsulin-dependent diabetes mellitus in the Pima Indians

1996 • 6 citations

Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity.

2002 • 5 citations

The Amino-Terminal Tail of Glycogen Phosphorylase Is a Switch for Controlling Phosphorylase Conformation, Activation, and Response to Ligands

2001 • 5 citations

Decreased responsiveness of gluconeogenesis to the modulation by sulfonylureas in hepatocytes isolated from obese (fa/fa) zucker rats

2001 • 4 citations