TNF-α Induces Two Distinct Caspase-8 Activation Pathways

The Inflammasome

2002 • 5,445 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

2007 • 1,166 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

2007 • 1,028 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

2006 • 956 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

2006 • 685 citations

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

2004 • 654 citations

Identification of the familial cylindromatosis tumour-suppressor gene

2000 • 654 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

2006 • 587 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

2007 • 562 citations

TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

2003 • 561 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Tumor Necrosis Factor

2004 • 491 citations

Life And Death Decisions

2004 • 337 citations

Ubiquitination of RIP1 Regulates an NF-κB-Independent Cell-Death Switch in TNF Signaling

2007 • 290 citations

Phosphatidylinositol 3-Kinase/Akt Activity Regulates c-FLIP Expression in Tumor Cells

2001 • 279 citations

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

2006 • 259 citations

Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells

2004 • 205 citations

Regulation of Early Wave of Germ Cell Apoptosis and Spermatogenesis by Deubiquitinating Enzyme CYLD

2007 • 197 citations

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

2005 • 185 citations

Competitive Control of Independent Programs of Tumor Necrosis Factor Receptor-Induced Cell Death by TRADD and RIP1

2006 • 142 citations

Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis

2006 • 132 citations