Enzymatic Oxidation of Xenobiotic Chemical

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

GLUTATHIONE

1983 • 5,487 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Metal-catalyzed Oxidations of Organic Compounds

1981 • 1,670 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Biochemistry of metallothionein

1988 • 1,222 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Oxidation of Persistent Environmental Pollutants by a White Rot Fungus

1985 • 914 citations

Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases

1988 • 912 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Enzymatic Reaction Mechanisms

1978 • 810 citations

Hydroxylation and epoxidation catalyzed by iron-porphine complexes. Oxygen transfer from iodosylbenzene

1979 • 799 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Cytochrome P-450

1986 • 734 citations

cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

1988 • 713 citations

The stereochemistry of peroxidase catalysis.

1980 • 683 citations

Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

1985 • 653 citations

N-acetylation pharmacogenetics.

1985 • 637 citations

Mechanism of multidrug resistance

1988 • 630 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism

1986 • 582 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Chemical mechanisms of catalysis by cytochromes P-450: a unified view

1984 • 481 citations

Catalytic asymmetric epoxidations with chiral iron porphyrins

1983 • 470 citations

Enzymatic reaction mechanisms

1980 • 469 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

Epoxidation reactions catalyzed by iron porphyrins. Oxygen transfer from iodosylbenzene

1983 • 459 citations

Oxidation of polycyclic aromatic hydrocarbons and dibenzo[p]-dioxins by Phanerochaete chrysosporium ligninase.

1986 • 455 citations

VITAMIN D: RECENT ADVANCES

1983 • 437 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Aerobic epoxidation of olefins with ruthenium porphyrin catalysts

1985 • 427 citations

Molecular cloning of complementary DNA encoding the lignin-forming peroxidase from tobacco: Molecular analysis and tissue-specific expression

1987 • 422 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Polycyclic Hydrocarbons and Carcinogenesis

1985 • 403 citations

Flavin coenzymes: at the crossroads of biological redox chemistry

1980 • 395 citations

Hydrocarbon oxidations with oxometalloporphinates. Isolation and reactions of a (porphinato)manganese(V) complex

1980 • 382 citations

Aliphatic hydroxylation catalyzed by iron porphyrin complexes

1983 • 369 citations

Chromyl chloride oxidations of olefins. Possible role of organometallic intermediates in the oxidations of olefins by oxo transition metal species

1977 • 354 citations

Flavin-containing monooxygenases: Catalytic mechanism and substrate specificities

1988 • 349 citations

Enzymatic activation of chemicals to toxic metabolites

1985 • 331 citations

Flavin-oxygen derivatives involved in hydroxylation by p-hydroxybenzoate hydroxylase.

1976 • 330 citations

Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium.

1987 • 326 citations

Acetylator genotype and arylamine-induced carcinogenesis

1988 • 325 citations

Multidrug Resistance1

1988 • 321 citations

Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450

1986 • 318 citations

Monoamine oxidase—I

1974 • 318 citations

Ab-Initio Molecular Orbital Studies of Structure and Reactivity of Transition Metal-OXO Compounds

1986 • 316 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Monoamine Oxidase Inhibitors

1979 • 298 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

On the mechanism of prostacyclin and thromboxane A2 biosynthesis

1989 • 287 citations

Oxidation of benzo(a)pyrene by extracellular ligninases of Phanerochaete chrysosporium. Veratryl alcohol and stability of ligninase.

1986 • 287 citations

Tosylamidation of cyclohexane by a cytochrome P-450 model

1982 • 269 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

Control of the catalytic activity of prosthetic heme by the structure of hemoproteins

1987 • 260 citations

Therapeutic attack of hypoxic cells of solid tumors: presidential address.

1988 • 258 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Inhibition of Cytochrome P450 Enzymes

2015 • 258 citations

Microsomal oxidase IV: Properties of a mixed-function amine oxidase isolated from pig liver microsomes

1972 • 257 citations

Biochemical significance of porphyrin .pi. cation radicals

1974 • 257 citations

フラビン補酵素 生物学的酸化-還元化学の交差点

1980 • 255 citations

Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.

1979 • 254 citations

Mechanisms of flavin catalysis

1980 • 251 citations

Mammalian cytochromes P-450

1987 • 248 citations

Cytochrome P-450—Catalyzed Formation of Δ ⁴ -VPA, a Toxic Metabolite of Valproic Acid

1987 • 248 citations

Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.

1984 • 246 citations

Enzymatic ω-Oxidation

1966 • 246 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

The oxidation-reduction potentials of compound I/compound II and compound II/ferric couples of horseradish peroxidases A2 and C.

1979 • 243 citations

DOPAMINE BETA-HYDROXYLASE OF ADRENAL CHROMAFFIN GRANULES: STRUCTURE AND FUNCTION

1988 • 240 citations

A new spectral intermediate associated with cytochrome P-450 function in liver microsomes

1971 • 240 citations

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

1978 • 239 citations

Cloning and sequencing of a cDNA for a ligninase from Phanerochaete chrysosporium

1987 • 236 citations

Microsomal Flavin-Containing Monooxygenase: Oxygenation of Nucleophilic Nitrogen and Sulfur Compounds

1980 • 235 citations

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.

1988 • 229 citations

Activation and transfer of nitrogen from a nitridomanganese(V) porphyrin complex. Aza analog of epoxidation

1983 • 227 citations

The Roles of Putidaredoxin and P450cam in Methylene Hydroxylation

1972 • 223 citations

Suicidal Destruction of Cytochrome P-450 During Oxidative Drug Metabolism

1983 • 223 citations

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

1989 • 221 citations

Hydroxylation by cytochrome P-450 and metalloporphyrin models. Evidence for allylic rearrangement

1984 • 219 citations

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

1988 • 217 citations

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

1982 • 215 citations

Sterically protected hemins with electronegative substituents: efficient catalysts for hydroxylation and epoxidation

1984 • 215 citations

Mechanism of the molybdenum and vanadium catalyzed epoxidation of olefins by alkyl hydroperoxides

1977 • 213 citations

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.

1982 • 213 citations

The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies.

1979 • 211 citations

Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.

1975 • 209 citations

Enzymatic ω-Oxidation

1970 • 204 citations

The Covalently‐Bound Flavin of Hepatic Monoamine Oxidase

1971 • 203 citations

The oxidative half-reaction of liver microsomal FAD-containing monooxygenase.

1981 • 202 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Chemical Mutation of Enzyme Active Sites

1984 • 199 citations

New flavins for old: artificial flavins as active site probes of flavoproteins

1986 • 197 citations

The Pseudomonas oleovorans alkane hydroxylase gene

1989 • 197 citations

Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.

1985 • 194 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Selective epoxidation of olefins by oxo[N-(2-oxidophenyl)salicylidenaminato]vanadium(V) alkylperoxides. On the mechanism of the Halcon epoxidation process

1986 • 191 citations

The mechanism of olefin epoxidation by oxo-iron porphyrins. Direct observation of an intermediate

1986 • 189 citations

Effect of Superoxide Generation and Dismutation on Hydroxylation Reactions Catalyzed by Liver Microsomal Cytochrome P-450

1971 • 189 citations

The oxidative 4-dechlorination of polychlorinated phenols is catalyzed by extracellular fungal lignin peroxidases

1988 • 186 citations

Preparation and characterization of an oxoporphinatochromium(V) complex

1979 • 183 citations

The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation.

1982 • 182 citations

Spectral characterization of the oxidized states of lignin peroxidase, an extracellular heme enzyme from the white rot basidiomycete Phanerochaete chrysosporium

1986 • 178 citations

Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems

1983 • 177 citations

Cytochrome P450 as an oxene transferase

1976 • 176 citations

Oxygenase-Catalyzed Biological Hydroxylations

1975 • 175 citations

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

1988 • 174 citations

Mitochondrial Monoamine Oxidase

1968 • 173 citations

Differential Changes in Monoamine Oxidase A and B Activity in the Aging Rat Brain

1980 • 173 citations

Metabolism of cyclosporine.

1985 • 172 citations

Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides

1977 • 172 citations

Aldehyde dehydrogenase from human liver

1984 • 171 citations

Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.

1982 • 170 citations

The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.

1983 • 161 citations

Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodies.

1987 • 160 citations

Timing of the radical recombination step in cytochrome P-450 catalysis with ring-strained probes

1987 • 160 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Oxidation of NADH involving rate-limiting one-electron transfer

1984 • 156 citations

Isolation of chick renal mitochondrial ferredoxin active in the 25-hydroxyvitamin D3-1alpha-hydroxylase system.

1976 • 156 citations

Mitochondrial Monoamine Oxidase

1967 • 153 citations

Human dopamine β-hydroxylase gene: two mRNA types having different 3'terminal regions are produced through alternative polyadenylation

1989 • 151 citations

Purification and properties of mitochondrial monoamine oxidase type A from human placenta.

1985 • 149 citations

Dietary Carcinogens and Anti-Carcinogens

1984 • 148 citations

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases.

1985 • 148 citations

Kinetics and Mechanisms of Reactions of Organic Cation Radicals in Solution

1984 • 147 citations

Reviews in biochemical toxicology

1984 • 147 citations

Enzymatic ω-Oxidation

1968 • 146 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

Presence and formation of codeine and morphine in the rat.

1986 • 141 citations

Interactions of monoamine oxidase with substrates and inhibitors

1989 • 141 citations

Mechanism of cytochrome P-450 inhibition by cyclopropylamines

1982 • 141 citations

Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase

1978 • 139 citations

Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450

1986 • 139 citations

Human Liver MAO-A and MAO-B Separated by Immunoaffinity Chromatography with MAO-B-Specific Monoclonal Antibody

1982 • 138 citations

Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450.

1983 • 134 citations

On the mechanism of the peroxidase-catalyzed oxygen-transfer reaction

1987 • 133 citations

Flavin and 5‐deazaflavin: A chemical evaluation of ‘modified’ flavoproteins with respect to the mechanisms of redox biocatalysis

1977 • 133 citations

Oxygen Activation and Transfer

1986 • 133 citations

The reductive half-reaction of liver microsomal FAD-containing monooxygenase.

1981 • 132 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Characterization of the enzymic and nonenzymic peroxidative degradation of iron porphyrins and cytochrome P-450 heme

1985 • 131 citations

The Pseudomonas oleovorans alkBAC operon encodes two structurally related rubredoxins and an aldehyde dehydrogenase

1989 • 131 citations

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

1988 • 131 citations

A very efficient system for alkene epoxidation by hydrogen peroxide: catalysis by manganese-porphyrins in the presence of imidazole

1985 • 131 citations

Enzymatic ω-Oxidation of Fatty Acids

1964 • 130 citations

Alkane hydroxylation catalyzed by metalloporhyrins : evidence for different active oxygen species with alkylhydroperoxides and iodosobenzene as oxidants.

1982 • 130 citations

Separation of two monoamine oxidases from bovine bran

1973 • 129 citations

The metabolism of¹⁴C-labelled trimethylamine and itsN-oxide in man

1987 • 129 citations

Structure-mechanism relationships in hemoproteins. Oxygenations catalyzed by chloroperoxidase and horseradish peroxidase.

1987 • 128 citations

Morphine and other opiates from beef brain and adrenal.

1985 • 127 citations

Interaction of Quinidine with Anticonvulsant Drugs

1976 • 126 citations

The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.

1987 • 125 citations

Oxygenation of styrene by cytochrome P-450 model systems. A mechanistic study

1986 • 125 citations

Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase.

1981 • 124 citations

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450

1976 • 124 citations

Ferricyanide oxidation of dihydropyridines and analogs

1984 • 124 citations

Amino acid sequence of an analogous peptide from two forms of cytochrome P-450.

1981 • 123 citations

Copper-Containing Oxidases and Superoxide Dismutase

1975 • 123 citations

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

1986 • 122 citations

A mechanism for mitochondrial monoamine oxidase catalyzed amine oxidation

1980 • 122 citations

The P-450 Nature of the Carbon Monoxide Complex of Ferrous Chloroperoxidase

1973 • 121 citations

Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450

1989 • 121 citations

Models for cytochrome P-450

1975 • 119 citations

Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene

1983 • 119 citations

Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes.

1978 • 117 citations

NIH shift in haemin–iodosylbenzene-mediated hydroxylations

1981 • 116 citations

Cloning of the gene encoding a catalytically self-sufficient cytochrome P-450 fatty acid monooxygenase induced by barbiturates in Bacillus megaterium and its functional expression and regulation in heterologous (Escherichia coli) and homologous (Bacillus megaterium) hosts.

1987 • 115 citations

Mechanism of oxygen atom transfer from high valent iron porphyrins to olefins: implications to the biological epoxidation of olefins by cytochrome P-450

1985 • 115 citations

Kinetic study on enzymatic s-oxygenation promoted by a reconstituted system with purified cytochrome P-450

1980 • 111 citations

A Genetic polymorphism of the N-oxidation of trimethylamine in humans

1987 • 111 citations

Synthesis of the skeleton of the morphine molecule by mammalian liver

1987 • 108 citations

Heme spin states and peroxide-induced radical species in prostaglandin H synthase.

1987 • 108 citations

A Genetically Engineered P450 Monooxygenase: Construction of the Functional Fused Enzyme between Rat Cytochrome P450c and NADPH-Cytochrome P450 Reductase

1987 • 107 citations

Chemical Mechanisms of Halocarbon Metabolism

1983 • 107 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit

1985 • 105 citations

Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.

1989 • 105 citations

Secondary isotope effects and structure-reactivity correlations in the dopamine .beta.-monooxygenase reaction: evidence for a chemical mechanism

1985 • 105 citations

Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme

1984 • 105 citations

Monooxygen donation potential of 4a-hydroperoxyflavins as compared with those of a percarboxylic acid and other hydroperoxides. Monooxygen donation to olefin, tertiary amine, alkyl sulfide, and iodide ion

1983 • 105 citations

Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA.

1982 • 103 citations

Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct.

1981 • 102 citations

Kinetic studies on the catalytic mechanism of liver monoamine oxidase

1982 • 102 citations

Role of ferryl (FeO2+) complexes in oxygen atom transfer reactions. Mechanism of iron(II) porphyrin catalyzed oxygenation of triphenylphosphine

1980 • 101 citations

[30] Deuterium and tritium kinetic isotope effects on initial rates

1982 • 100 citations

The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids.

1988 • 99 citations

Mechanism of cytochrome P-450 catalysis. Mechanism of N-dealkylation and amine oxide deoxygenation

1985 • 99 citations

Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects

1986 • 99 citations

Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: Characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and rat

1985 • 99 citations

Spectroscopic and kinetic properties of the oxidized intermediates of lignin peroxidase from Phanerochaete chrysosporium.

1988 • 98 citations

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

1982 • 98 citations

Analysis of Enzyme Structure and Activity by Protein Engineering

1984 • 97 citations

Co-oxidation of benzidine by prostaglandin synthase and comparison with the action of horseradish peroxidase.

1983 • 96 citations

Reactions Catalyzed by the Cytochrome P-450 System

1980 • 95 citations

Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA.

1981 • 95 citations

The Metabolism of Pyrene

1957 • 94 citations

Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP)+, the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1988 • 92 citations

Mechanism of inactivation of monoamine oxidase by trans-2-phenylcyclopropylamine and the structure of the enzyme-inactivator adduct.

1983 • 92 citations

Hydrogen-deuterium exchange during propylene epoxidation by cytochrome P-450

1986 • 92 citations

Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione.

1986 • 91 citations

Acetaminophen: enzymatic formation of a transient phenoxyl free radical

1984 • 91 citations

Prostagland in synthetase dependent benzo(a)pyrene oxidation: Products of the oxidation and inhibition of their formation by antioxidants

1977 • 91 citations

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.

1984 • 90 citations

Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.

1985 • 90 citations

Metabolic oxidation of acetaminophen (Paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney

1981 • 90 citations

Rabbit lung flavin-containing monooxygenase. Purification, characterization, and induction during pregnancy.

1985 • 89 citations

Stereospecific aliphatic hydroxylation by an iron-based oxidant

1974 • 89 citations

Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 89 citations

Xenobiotic Metabolism by Prostaglandin Endoperoxide Synthetase

1983 • 88 citations

Monoamine Oxidase Inhibitors

2016 • 88 citations

Substrate free radicals are intermediates in ligninase catalysis.

1986 • 88 citations

Oxidation of Cycloalkylamines by Cytochrome P-450

1989 • 87 citations

Studies on compound I formation of the lignin peroxidase from Phanerochaete chrysosporium.

1988 • 87 citations

Mono-oxigenase-like dioxygen activation leading to alkane hydroxylation and olefin epoxidation by an Mn^III(porphyrin)–ascorbate biphasic system

1983 • 87 citations

Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates.

1986 • 87 citations

Ueber die nach Einführung von Brombenzol und Chlorbenzol im Organismus entstehenden schwefelhaltigen Säuren

1879 • 87 citations

Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.

1978 • 87 citations

Influence of nitrogen base ligation and hydrogen bonding on the rate constants for oxygen transfer from percarboxylic acids and alkyl hydroperoxides to (meso-tetraphenylporphinato)manganese(III) chloride

1986 • 87 citations

Cytochrome P‐450 isozyme/isozyme functional interactions and NADPH‐cytochrome P‐450 reductase concentrations as factors in microsomal metabolism of warfarin

1985 • 86 citations

Enzymatic Oxidation of Alkyl Sulfides by Cytochrome P-450 and Hydroxyl Radical

1981 • 86 citations

Progress in drug metabolism

1988 • 86 citations

Mechanism-based inactivation of cytochrome P-450 by heteroatom-substituted cyclopropanes and formation of ring-opened products

1984 • 86 citations

Isolation of morphine from toad skin.

1985 • 86 citations

Ueber Bromphenylmercaptursäure

1879 • 85 citations

Prostaglandin synthetase catalyzed activation of paracetamol

1982 • 85 citations

Oxidative cleavage of carboxylic esters by cytochrome P-450.

1987 • 83 citations

Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes.

1988 • 83 citations

Selective epoxidation of olefins by molybdenum porphyrin catalyzed peroxy-bond heterolysis

1981 • 82 citations

Bovine liver monoamine oxidase

1978 • 82 citations

Purification of the flavin-containing monooxygenase from mouse and pig liver microsomes

1984 • 81 citations

Homolytic and heterolytic oxygen-oxygen bond scissions accompanying oxygen transfer to iron(III) porphyrins by percarboxylic acids and hydroperoxides. A mechanistic criterion for peroxidase and cytochrome P-450

1985 • 81 citations

Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes.

1989 • 81 citations

Mechanistic studies on non-heme iron monooxygenase catalysis: epoxidation, aldehyde formation and demethylation by the .omega.-hydroxylation system of Pseudomonas oleovorans

1984 • 80 citations

Peroxidase-mediated formation of reactive metabolites of acetaminophen.

1981 • 80 citations

The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase.

1987 • 80 citations

Novel haloperoxidase substrates. Alkynes and cyclopropanes.

1983 • 80 citations

Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity.

1988 • 80 citations

The deprotonation of trialkylamine cation radicals by amines

1986 • 79 citations

Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines.

1988 • 78 citations

Mechanisms of hemin-catalyzed epoxidations: electron transfer from alkenes

1987 • 78 citations

Characterization of the ω-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein

1977 • 77 citations

Binding of metabolically activated benzo(a)pyrene to nuclear macromolecules.

1976 • 77 citations

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.

1984 • 76 citations

Formation of an iron(III)-porphyrin complex with a nitrene moiety inserted into an iron-nitrogen bond during alkene aziridination by (tosylimidoiodo)benzene catalyzed by iron(III) porphyrins

1986 • 76 citations

Hepatic mitochondrial cytochrome P-450 system. Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene.

1984 • 75 citations

Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.

1988 • 75 citations

Prostaglandin H synthase-dependent epoxidation of aflatoxin B₁

1985 • 75 citations

Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum

1989 • 75 citations

Asymmetric sulfoxidation by dopamine .beta.-hydroxylase, an oxygenase heretofore considered specific for methylene hydroxylation

1980 • 75 citations

Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria.

1988 • 74 citations

Prostaglandin H synthase: Distinct binding sites for cyclooxygenase and peroxidase substrates

1988 • 74 citations

Oxidation of catechol by horseradish peroxidase and human leukocyte peroxidase: Reactions of o-benzoquinone and o-benzosemiquinone*1

1988 • 74 citations

25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondria

1988 • 74 citations

Peroxide oxidation of primary alcohols to aldehydes by chloroperoxidase catalysis

1983 • 74 citations

Hydroxylation of alkanes by hydrogen peroxide: and efficient system using manganese porphyrins and imidazole as catalysts

1986 • 74 citations

The sub-mitochondrial localization of monoamine oxidase in rat liver and brain

1967 • 73 citations

Comparison of rates of enzymic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses

1989 • 73 citations

Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase)

1989 • 72 citations

Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin.

1980 • 72 citations

Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues.

1982 • 72 citations

Suicide inactivation of monoamine oxidase by trans-phenylcyclopropylamine.

1980 • 72 citations

Enzymatic ω Oxidation

1972 • 72 citations

The Purification of Pig Brain Mitochondrial Monoamine Oxidase

1968 • 71 citations

26-Hydroxylation of C27-steroids by soluble liver mitochondrial cytochrome P-450.

1979 • 71 citations

Electrochemical generation of an iron(IV) porphyrin

1986 • 70 citations

Rate-determining general-base catalysis in an obligate 1e- oxidation of a dihydropyridine

1984 • 70 citations

Inhibition by aspirin of N-[4-(5-nitro-2furyl)-2thiazolyl]formamide induced bladder carcinogenesis and enhancement of forestomach carcinogenesis

1984 • 70 citations

Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles

1979 • 69 citations

Biochemical mechanism of aromatization.

1982 • 69 citations

Epoxidation of alkenes by chloroperoxidase catalysis

1986 • 69 citations

One electron transfer mechanism in the enzymatic oxygenation of sulfoxide to sulfone promoted by a reconstituted system with purified cytochrome p-450

1982 • 68 citations

Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylations

1979 • 68 citations

Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nitrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 68 citations

Models for ferric cytochrome P450. Characterization of hemin mercaptide complexes by electronic and ESR spectra

1979 • 68 citations

Epoxidation of cyclic alkenes by bis(acetonitrile)chloronitropalladium(II): on the role of heterometallacyclopentanes and .beta.-hydrogen elimination in the catalytic oxidation of alkenes

1982 • 68 citations

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

1987 • 68 citations

Oxygenation of organosulfur compounds by peroxidases: Evidence of an electron transfer mechanism for lactoperoxidase

1986 • 67 citations

On the active site of liver acetyl-CoA. Arylamine N-acetyltransferase from rapid acetylator rabbits (III/J).

1988 • 67 citations

Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine

1985 • 67 citations

Inactivation of dopamine .beta.-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides

1988 • 67 citations

A monoclonal antibody elicited to human platelet monoamine oxidase. Isolation and specificity for human monoamine oxidase B but not A.

1982 • 67 citations

Substrate specificity of the rabbit lung flavin-containing monooxygenase for amines: oxidation products of primary alkylamines.

1986 • 67 citations

Cysteine conjugate beta-lyase.

1983 • 67 citations

Role of molecular oxygen in lignin peroxidase reactions

1986 • 67 citations

Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism

1986 • 67 citations

Magnitude of intrinsic isotope effects in the dopamine .beta.-monooxygenase reaction

1983 • 66 citations

cDNA and protein structure for the .alpha. subunit of human liver alcohol dehydrogenase

1986 • 65 citations

Studies on the Metabolism of Ethynylestradiolin vitroandin vivo: The Significance of 2-Hydroxylation and the Formation of Polar Products

1973 • 65 citations

Cytochrome P-450 LM2 Reduction

1989 • 64 citations

Pharmacogenetics of methylation: Relationship to drug metabolism

1988 • 64 citations

Inhibition of Cytochrome P-450 Enzymes

1986 • 64 citations

A single amino acid substitution converts cytochrome P45014DM to an inactive form, cytochrome P450SG1: Complete primary structures deduced from cloned DNAs

1988 • 64 citations

Intercalation of potentially reactive transition-metal complexes in the lamellar manganese phosphide sulfide host lattice

1981 • 63 citations

Acidities of radical cations derived from remotely substituted and phenyl-substituted fluorenes

1988 • 63 citations

Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidine

1988 • 63 citations

Mechanism-based inactivation of dopamine .beta.-hydroxylase by p-cresol and related alkylphenols

1987 • 62 citations

Lignin peroxidase: resonance Raman spectral evidence for compound II and for a temperature-dependent coordination-state equilibrium in the ferric enzyme

1987 • 62 citations

Use of the N-oxide of p-cyano-N,N-dimethylaniline as an "oxygen" donor in a cytochrome P-450 model system

1982 • 62 citations

Radical mechanism of aminopyrine oxidation by cumene hydroperoxide catalyzed by purified liver microsomal cytochrome P-450

1980 • 61 citations

Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2, 6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts

1987 • 61 citations

Transient formation of N-alkylhemins during hemin-catalyzed epoxidation of norbornene. Evidence concerning the mechanism of epoxidation

1987 • 61 citations

Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N[2(ochlorophenoxy)-ethyl]-cyclopropylamine

1968 • 61 citations

Stabilization of higher-valent states of iron porphyrin by hydroxide and methoxide ligands: electrochemical generation of iron(IV)-oxo porphyrins.

1985 • 61 citations

Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes.

1985 • 61 citations

Cytochrome P-450 catalyzed oxidation of quadricyclane. Evidence for a radical cation intermediate

1985 • 61 citations

Picosecond observation of kinetic vs. thermodynamic hydrogen atom transfer

1983 • 61 citations

Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomes

1976 • 60 citations

Metabolism and reactions of alkylating agents

1987 • 60 citations

An update on the identity crisis of monoamine oxidase: new and old evidence for the independence of mao A and B

1985 • 60 citations

4a-Hydroperoxyflavin N-oxidation of tertiary amines

1979 • 60 citations

Phenol sulfotransferase in humans: properties, regulation, and function.

1986 • 60 citations

Copper ion mediated epoxidation of olefins by iodosylbenzene

1984 • 59 citations

Haloperoxidase reactions catalyzed by lignin peroxidase, an extracellular enzyme from the basidiomycete Phanerochaete chrysosporium

1987 • 59 citations

Expression inSaccharomyces cerevisiaeof Chimeric Cytochrome P450 cDNAs Constructed from cDNAs for Rat Cytochrome P450c and P450d

1987 • 58 citations

Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes.

1987 • 58 citations

On the Mechanism of Action of Cytochrome P-450

1989 • 58 citations

Olefin oxygenation and N-dealkylation by dopamine .beta.-monooxygenase: catalysis and mechanism-based inhibition

1985 • 57 citations

Thyroid peroxidase selects the mechanism of either 1- or 2-electron oxidation of phenols, depending on their substituents.

1985 • 57 citations

Serum cyclosporin levels, hepatic drug metabolism and renal tubulotoxicity

1984 • 57 citations

Epoxidation of olefins by iodosylbenzene catalyzed by binuclear copper(II) complexes

1986 • 57 citations

Demethylation of N,N-dimethylaniline and p-cyano-N,N-dimethylaniline and their N-oxides by cytochromes P450LM2 and P450CAM

1984 • 57 citations

Identification of the fifth axial heme ligand of chloroperoxidase.

1988 • 56 citations

Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.

1987 • 55 citations

Mechanisms of EnzymaticS-Oxygenation of Thioanisole Derivatives andO-Demethylation of Anisole Derivatives Promoted by Both Microsomes and a Reconstituted System with Purified Cytochrome P-450

1982 • 55 citations

Combined 17α-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17α-hydroxylase cytochrome P-450

1988 • 55 citations

Identity of the active site flavin-peptide fragments from the human “A”-form and the bovine “B”-form of monoamine oxidase

1981 • 54 citations

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems

1980 • 53 citations

Immunological uniqueness of human monoamine oxidases A and B: new evidence from studies with monoclonal antibodies to human monoamine oxidase A

1985 • 53 citations

Purification of mixed-function amine oxidase from rat liver microsomes

1983 • 53 citations

Mechanism-based inactivation of mitochondrial monoamine oxidase by N-(1-methylcyclopropyl)benzylamine

1984 • 53 citations

Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10,-epoxide metabolites induced by changes in pH

1977 • 53 citations

Highly purified microsomal P-450: The oxyferro intermediate stabilized at low temperature

1979 • 53 citations

10-Hydroperoxy-8,12-octadecadienoic acid. A diagnostic probe of alkoxyl radical generation in metal-hydroperoxide reactions

1987 • 53 citations

The CC bond cleavage of a lignin model compound, 1,2-diarylpropane-1,3-diol, with a heme-enzyme model catalyst tetraphenylporphyrinatoiron (III) chloride in the presence of tert-butylhydroperoxide

1984 • 52 citations

Hepatic microsomal N-dealkylation reaction. Molecular oxygen as the source of the oxygen atom

1969 • 52 citations

Platelet Monoamine Oxidase Activity: Demographic Characteristics Contribute to Enzyme Activity Variability

1985 • 52 citations

Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity.

1986 • 50 citations

[49] Preparation of monoamine oxidase from beef liver mitochondria

1978 • 50 citations

A mono-ozygenase model for selective aromatic hydroxylation with nickel(II)-macrocyclic polyamines

1984 • 50 citations

Endogenous Substrates for Udp-Glucuronosyl-Transferases

1988 • 50 citations

Iron(II)-induced activation of hydroperoxides for the dehydrogenation and monooxygenation of organic substrates in acetonitrile

1985 • 49 citations

Oxidation of sparteines by cytochrome P-450: evidence against the formation of N-oxides

1984 • 49 citations

Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagents

1971 • 49 citations

Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.

1988 • 49 citations

Reversible iron-nitrogen migration of alkyl, aryl, or vinyl groups in iron porphyrins: a possible passage between .sigma. FeIII(porphyrin)(R) and FeII(N-R)(porphyrin)complexes

1982 • 49 citations

Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase

1988 • 49 citations

On the rate-determining step in the epoxidation of olefins by monooxygenase models

1986 • 49 citations

Mechanisms of hydroxylation by cytochrome P-450: Exchange of iron-oxygen intermediates with water

1982 • 49 citations

Photocatalytic oxidation of hydrocarbons by (5,10,15,20-tetraphenylporphyrinato)manganese(II) perchlorate and periodate

1987 • 48 citations

Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adducts

1986 • 48 citations

Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways

1986 • 48 citations

N-Alkylporphyrin formation during the reactions of cytochrome P-450 model systems

1985 • 48 citations

Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthase and horseradish peroxidase.

1986 • 48 citations

Amine N-methyltransferases from rabbit liver.

1986 • 47 citations

18O studies of the peroxidase-catalyzed oxidation of N-methylcarbazole. Mechanisms of carbinolamine and carboxaldehyde formation.

1986 • 47 citations

Rabbit liver cytochrome P-450 LM2: roles of substrates, inhibitors, and cytochrome b5 in modulating the partition between productive and abortive mechanisms

1987 • 47 citations

1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

1984 • 46 citations

Effect of substrate on the spin state of cytochrome P-450 in hepatic microsomes

1973 • 46 citations

Dioxygen-copper reactivity. Reversible oxygen and carbon monoxide binding by a new series of binuclear copper(I) complexes

1985 • 46 citations

The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies.

1985 • 46 citations

Oxygen transfer from bleomycin-metal complexes.

1982 • 46 citations

Copper-dioxygen chemistry. Synthesis and properties of a dicopper(II)-peroxide complex

1984 • 45 citations

Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed

1986 • 45 citations

Ueber Verwandlung der Benzoësäure in Hippursäure

1842 • 45 citations

The generation of a hyperporphyrin spectrum upon thiol binding to ferric chloroperoxidase. Further evidence of endogenous thiolate ligation to the ferric enzyme.

1984 • 45 citations

Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism

1987 • 45 citations

Steric course of hydroxylation at primary carbon atoms. Biosynthesis of 1-octanol from (1R)- and (1S)-[1-3H,2H,1H; 1-14C]octane by rat liver microsomes

1982 • 45 citations

Crabtree effect in tumoral pancreatic islet cells.

1988 • 45 citations

Kinetic isotope effects and ‘metabolic switching’ in cytochrome P450‐catalyzed reactions

1987 • 44 citations

Flavohemoglobin: a semisynthetic hydroxylase acting in the absence of reductase

1987 • 44 citations

3-Phenylpropenes as mechanism-based inhibitors of dopamine .beta.-hydroxylase: evidence for a radical mechanism

1985 • 44 citations

Biological Basis of Detoxication of Oxygen Free Radicals

1983 • 44 citations

The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis

1988 • 44 citations

Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450

1995 • 44 citations

Pharmacogenetics of N-methylation: Heritability of human erythrocyte histamine N-methyltransferase activity

1988 • 43 citations

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria.

1983 • 43 citations

Hydrogen bonding to the proximal imidazole in heme protein model compounds: effects upon oxygen binding and peroxidase activity

1988 • 43 citations

Isolation from bovine liver mitochondria of a soluble ferredoxin active in a reconstituted steroid hydroxylation reaction

1977 • 41 citations

4-Alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines

1988 • 41 citations

Catalytic epoxidation of aliphatic terminal olefins with sodium hypochlorite

1984 • 40 citations

Steroid regulation of monoamine oxidase activity in the adrenal medulla

1989 • 40 citations

Acetylenic mechanism-based inhibitors of cholesterol side chain cleavage by cytochrome P-450scc.

1983 • 40 citations

Stopped-flow studies on the mechanism of oxidation of N-methyl-4-phenyltetrahydropyridine by bovine liver monoamine oxidase B

1987 • 39 citations

Mechanism-based inhibitors of dopamine β-hydroxylase

1987 • 39 citations

Oxidation of sulfide with ArIO catalyzed with TPPM(III)Cl

1982 • 39 citations

III. Bioactivation of MPTP: Reactive metabolites and possible biochemical sequelae

1987 • 39 citations

Peroxyl radical- and cytochrome P-450-dependent metabolic activation of (+)-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in mouse skin in vitro and in vivo.

1989 • 38 citations

Comparison of sulfide oxygenation mechanism for liver microsomal FAD-containing monooxygenase with that for cytochrome P-450

1985 • 38 citations

Electrochemistry in liquid sulfur dioxide. 3. Electrochemical production of new highly oxidized 2,2'-bipyridine complexes of ruthenium and iron

1982 • 38 citations

Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction.

1984 • 38 citations

Mild and selective oxygen atom transfer:nBu4NIO4 with metalloporphyrins

1983 • 38 citations

N-methylation: potential mechanism for metabolic activation of carcinogenic primary arylamines.

1988 • 38 citations

Characterization of Rabbit Liver Cytochrome P-450 (Laurate ω-1 Hydroxylase) Synthesized in Transformed Yeast Cells1

1988 • 38 citations

Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes.

1981 • 37 citations

Hepatic mitochondrial cytochrome P-450 system. Purification and characterization of two distinct forms of mitochondrial cytochrome P-450 from beta-naphthoflavone-induced rat liver.

1988 • 37 citations

Enzymatic monooxygenation of halogen atoms: cytochrome P-450 catalyzed oxidation of iodobenzene by iodosobenzene

1980 • 36 citations

Dopamine-B-hydroxylase: Suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene

1983 • 35 citations

Production of superoxide ions in rat liver microsomes

1973 • 35 citations

Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine

1988 • 35 citations

Metabolism of aromatic amines by prostaglandin H synthase.

1985 • 35 citations

Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-alpha-(2-methylazo)-p-toluamide, the azo derivative of procarbazine.

1984 • 35 citations

Arachidonic acid-dependent metabolism of (±)-7,8-dihydroxy-7,8-dihydrobenzo[A]pyrene to polyguanylic acid-binding derivatives

1981 • 35 citations

1-Phenylcyclobutylamine, the first in a new class of monoamine oxidase inactivators. Further evidence for a radical intermediate

1986 • 34 citations

Iodine‐ and chlorine‐containing oxidation agents as hydroxylating catalysts in cytochrome P‐450‐dependent fatty acid hydroxylation reactions in rat liver microsomes

1976 • 34 citations

Immunochemical Study on the Route of Electron Transfer from NADH and NADPH to Cytochrome P-450 of Liver Microsomes

1980 • 34 citations

Model studies on the active site of cytochrome P-450 : an Fe^II–porphyrin carrying a strapped thiolate ligand

1982 • 34 citations

Thermodynamic properties of oxidation-reduction reactions of bacterial, microsomal, and mitochondrial cytochromes P-450: an entropy-enthalpy compensation effect

1986 • 33 citations

Dopamine beta-hydroxylase. Demonstration of enzymatic ketonization of the product enantiomer S-octopamine.

1981 • 33 citations

Cytochrome P-450 Related to P-4504 from Phenobarbital-Treated Rabbit Liver: Molecular Cloning of cDNA and Characterization of Cytochrome P-450 Obtained by Its Expression in Yeast Cells1

1987 • 33 citations

Identification of the convulsant opiate thebaine in mammalian brain.

1989 • 33 citations

.beta.-Substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine .beta.-hydroxylase

1988 • 32 citations

Composition of cytochrome P‐450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti‐(rat cytochrome P‐450)

1984 • 32 citations

Mechanism-based inhibitors of dopamine .beta.-hydroxylase containing acetylenic or cyclopropyl groups

1985 • 32 citations

Cytochrome P-450 modelling oxygenation of olefins within the space-restricted cavity of iron “binap porphyrin”: Rate enhancement in the presence of imidazole

1987 • 32 citations

The rate ofN-demethylation ofN,N-dimethylanilines andN-methylanilines by rat-liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor

1986 • 32 citations

Inactivation of purified rat liver cytochrome P-450 by chloramphenicol.

1980 • 32 citations

Enzyme systems involved in the formation of reactive metabolites in the renal medulla: Cooxidation via prostaglandin H synthase*1

1984 • 32 citations

Ferric chloride-catalyzed activation of hydrogen peroxide for the demethylation of N,N-dimethylaniline, the epoxidation of olefins, and the oxidative cleavage of vicinal diols in acetonitrile: a reaction mimic for cytochrome P-450.

1987 • 31 citations

Shape-selective alkane hydroxylation

1985 • 31 citations

Arachidonic acid-dependent cooxidation

1984 • 31 citations

Effect of .alpha.-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine

1984 • 31 citations

Mechanism of aromatic ring cleavage of a .beta.-biphenylyl ether dimer catalyzed by lignin peroxidase of Phanerochaete chrysosporium

1988 • 31 citations

Oxidation of Halogenated Compounds by Cytochrome P-450, Peroxidases, and Model Metalloporphyrins

1989 • 30 citations

Reduction of alkyl hydroperoxides to alcohols: Role of rubredoxin, an electron carrier in the bacterial hydroxylation of hydrocarbons

1971 • 30 citations

Iron(IV) porphyrins from iron(III) porphyrin cation radicals

1984 • 29 citations

Amine N-sulfotransferase.

1987 • 29 citations

Revised mechanism for inactivation of mitochondrial monoamine oxidase by N-cyclopropylbenzylamine

1985 • 29 citations

Characterization of highly purified dopamine β-hydroxylase

1987 • 28 citations

Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.

1984 • 28 citations

A stable aryldialkoxybrominane. Synthesis, structure, and reactions of an organo-nonmetallic 10-Br-3 species

1986 • 28 citations

Photochemical expoxidation of olefins with molecular oxygen activated by niobium porphyrin: a functional model of cytochrome P-450

1985 • 27 citations

(Aminoalkyl)trimethylsilanes. A new class of monoamine oxidase inactivators

1987 • 27 citations

Hepatic mitochondrial coumarin 7-hydroxylase: Comparison with the microsomal enzyme

1988 • 27 citations

Monoamine oxidase A and monoamine oxidase B activities are catalyzed by different proteins

1985 • 27 citations

MNDO calculation of kinetic isotope effects in model cytochrome P-450 oxidations

1983 • 26 citations

Synthesis and study of a 6-amino-5-oxo-3H,5H-uracil and derivatives. The structure of an intermediate proposed in mechanisms of flavin and pterin oxygenases

1983 • 26 citations

Prostaglandin H synthase-dependent co-oxygenation of (±)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants

1984 • 26 citations

The Crystal Structure of Cytochrome P-450cam

1986 • 26 citations

Prostaglandin hydroperoxidase-catalyzed activation of certain N-substituted aryl renal and bladder carcinogens

1983 • 26 citations

The Effect of Hepatic Metabolism on the Production and Toxicity of Reactive Metabolites in Extrahepatic Organs

1983 • 25 citations

Activation of the parasympathomimetic alkaloid slaframine by microsomal and photochemical oxidation.

1977 • 25 citations

Hepatic mitochondrial cytochrome P-450 system. Identification and characterization of a precursor form of mitochondrial cytochrome P-450 induced by 3-methylcholanthrene.

1988 • 24 citations

Flavoprotein monooxygenases: a chemical model

1981 • 24 citations

Differences between nuclear and microsomal cytochrome P-450 in uninduced and induced rat liver.

1978 • 24 citations

Arachidonic Acid Metabolism and Tumor Initiation

1985 • 23 citations

Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice.

1983 • 23 citations

Alkylation of the prosthetic heme in cytochrome P-450 during oxidative metabolism of the sedative-hypnotic ethchlorvynol

1982 • 23 citations

The metabolic basis for combination chemotherapy

1988 • 23 citations

Arachidonic Acid Metabolism and Tumor Initiation

1985 • 22 citations

Source of the oxygen atom in the product of cytochrome P-450-catalyzed N-demethylation reactions.

1983 • 22 citations

High-valent oxo complexes of osmium as selective oxidants for cyclohexene oxidation. Complexation of the bisamide tetradentate ligand bpb to osmium and the X-ray structure of trans-[os^III(bpb)(PPh₃)Cl][bpbH₂=N,N′-bis(2′-pyridine-carboxamide)-1,2-benzene]

1986 • 22 citations

Inactivation of cytochrome p-450 by 2-isopropyl-4- pentenamide and other xenobiotics leads to heme-derived protein adducts

1986 • 22 citations

Cyclosporine-phenytoin interaction.

1988 • 21 citations

Crystallization of cytochrome P‐450_scc from bovine adrenocortical mitochondria

1988 • 21 citations

Human liver cytosolic epoxide hydrolases

1988 • 21 citations

Inactivation of monoamine oxidase A by the monoamine oxidase B inactivators 1-phenylcyclopropylamine, 1-benzylcyclopropylamine, and N-cyclopropyl-.alpha.-methylbenzylamine

1988 • 21 citations

3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4

1986 • 20 citations

Regioselectivity changes in hexane hydroxylation by iodozobenzene catalyzed by tetraarylporphyrinatoiron complexes

1985 • 20 citations

Reducing substrate activity of some aromatic amines for prostaglandin H synthase

1987 • 20 citations

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: Full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters

1985 • 19 citations

Effect of spin state on reduction of cytochrome P-450 (P-450c21) from bovine adrenocortical microsomes

1982 • 19 citations

The Topology of the Mammalian Cytochrome P-450 Active Site

1986 • 18 citations

[10] Preparation, analysis, and biochemical applications of chiral methyl groups

1982 • 18 citations

Interactions of diethylphenylphosphine with purified, reconstituted mouse liver cytochrome P-450 monooxygenase systems

1986 • 17 citations

cDNA and complete amino acid sequence of mouse P₂450: allelic variant of mouse P₃450 gene

1986 • 17 citations

Catalysed epoxidation and hydroxylation of alkene by osmium(<scp>III</scp>)–porphyrin complexes

1986 • 16 citations

Comparison of the Peroxidase Activity of Hemeproteins and Cytochrome P-450

1986 • 15 citations

Mechanism-based inhibition of dopamine beta-monooxygenase by aldehydes and amides.

1986 • 15 citations

Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.

1987 • 15 citations

Intervention of N,N-dimethylanilinium cation radical in the polononovski type reaction of N.N-dimethylaniline N-oxide catalyzed by meso-tetraphenylporphinatoiron/imidazole

1986 • 15 citations

Nature of the intermediate between 4a-hydroperoxyflavin and 4a-hydroxyflavin in the hydroxylation reaction of p-hydroxybenzoate hydroxylase. Synthesis of 6-aminopyrimidine-2,4,5(3H)-triones and the mechanism of aromatic hydroxylation by flavin monooxygenases

1981 • 15 citations

Oxidation of N-nitrosodibenzylamine and related compounds by metalloporphyrin-catalysed model systems for the cytochrome P450 dependent mono-oxygenases

1984 • 14 citations

Nuclear Activation of Polycyclic Hydrocarbons

1979 • 14 citations

Characterization of a product derived from the 1-methyl-4-phenyl-2,3-dihydropyridinium ion, a metabolite of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 14 citations

Monoamine Oxidase

1980 • 14 citations

Mechanism for reactivation of N-cyclopropylbenzylamine-inactivated monoamine oxidase by amines

1985 • 14 citations

Use of an oxaziridine as an oxene transfer agent to manganese(III)tetraphenylporphyrin chloride

1985 • 13 citations

The molecular basis of hereditary acetylation polymorphisms.

1986 • 13 citations

Transformations of arylpropane lignin model compounds by a lignin peroxidase of the white-rot fungus Phanerochaete chrysosporium

1986 • 13 citations

Nucleolar cytochrome P-450.

1980 • 13 citations

Cooxidation of styrene by horseradish peroxidase and glutathione.

1986 • 13 citations

The possibility that the spectrum of intermediate two, seen in the course of reaction of flavoenzyme phenol hydroxylases, may be attributable to iminol isomers of a flavin-derived 6-arylamino-5-oxo(3H,5H)uracil.

1984 • 13 citations

Purification and Characterization of Cysteine Conjugate Transaminases from Rat Liver

1988 • 13 citations

Metabolic activation of the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide by prostaglandin H synthase

1984 • 12 citations

Polymer biochemistry: Radical breakdown of lignin

1985 • 12 citations

DNA repair in genes

1988 • 12 citations

Spectroscopic models for cytochrome P-450 derivatives: hyperporphyrin spectra in thiolatoiron(<scp>III</scp>)–porphyrin complexes

1986 • 11 citations

Thiol-containing peptide-hemin complexes as models of cytochrome P-450

1983 • 10 citations

N-oxidation of N,N-dimethylaniline in the rabbit and rat lung

1983 • 10 citations

Peroxidase-catalyzed N-demethylation reactions: deuterium solvent isotope effects

1985 • 9 citations

Characterization of mutagenic glucuronide formation from benzo(a)pyrene in the nonrecirculating perfused rat liver.

1984 • 8 citations

Kinetic studies of the reactions of benzo[a]pyrene-7,8-diol 9,10-epoxides in aqueous solutions of human serum albumin and nonionic micelles

1988 • 8 citations

A New Class of Monoamine Oxidase Inhibitors

1980 • 8 citations

Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver

1980 • 8 citations

Quantitative relationships between structure and microsomal oxidation rate of 1,4-dihydropyridines

1986 • 8 citations

(Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators

1987 • 8 citations

Isotopic sensitivity in the microsomal oxidation of the dihydropyridine calcium entry blocker nifedipine

1989 • 7 citations

Oxygen-18 studies on the oxidative deamination mechanism of alicyclic primary amines in rabbit liver microsomes

1982 • 7 citations

Chapter 27. Enzyme Changes Linked to Anticancer Drug Resistance

1988 • 6 citations

Determination of the kinetic pK a of a flavin 4a-pseudobase from a study of the hydrolysis of 4a-hydroxy-5-ethyl-3-methyl-lumiflavin in H2O. The oxygen donation potential of 4a-hydroperoxyflavins

1984 • 6 citations

ChemInform Abstract: ALKYLATION OF THE PROSTHETIC HEME IN CYTOCHROME P‐450 DURING OXIDATIVE METABOLISM OF THE SEDATIVE‐HYPNOTIC ETHCHLORVYNOL

1983 • 5 citations

Monoamine Oxidase Type B Inhibitors in Human and Animal Parkinsonism

1986 • 4 citations

Hydride vs. electron transfer in the oxidation of NADH model compounds.

1988 • 4 citations

More Clues to the Cause of Parkinson's Disease

1987 • 4 citations

Pharmacokinetics and metabolism of nifedipine and its metabolites in rats : in-vivo oxidative cleavage of a pyridine-carboxylic acid ester metabolite of nifedipine

1990 • 3 citations

ChemInform Abstract: Aerobic Epoxidation of Olefins with Ruthenium Porphyrin Catalysts.

1986 • 1 citations

Deleted Work

1955 • 0 citations