Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts

1981 • 830 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide

1978 • 569 citations

Oxygen and oxy‐radicals in chemistry and biology

1982 • 557 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical-generating systems

1981 • 498 citations

Serum Ferritin in Patients with Iron Overload and with Acute and Chronic Liver Diseases

1975 • 344 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

The Binding of Cytochrome b5 to Liver Microsomes

1972 • 286 citations

Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

1977 • 261 citations

Alloxan-induced diabetes—evidence for hydroxyl radical as a cytotoxic intermediate

1976 • 249 citations

Temperature dependence of cytochrome P-450 reduction. A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction.

1976 • 241 citations

Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

1982 • 235 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

Radical addition reactions of 5,5-Dimethyl-1-pyrroline-1-oxide. ESR spin trapping with a cyclic nitrone

1973 • 214 citations

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

1979 • 206 citations

Oxidase and Oxygenase Function of the Microsomal Cytochrome P450 Monooxygenase System

1982 • 195 citations

THE EFFECT OF IRON ON THE DISTRIBUTION OF SUPEROXIDE AND HYDROXYL RADICALS AS SEEN BY SPIN TRAPPING AND ON THE SUPEROXIDE DISMUTASE ASSAY

1978 • 179 citations

Superoxide dismutase is a prophylactic against alloxan diabetes

1981 • 166 citations

Inhibition of Alloxan Action in Isolated Pancreatic Islets by Superoxide Dismutase, Catalase, and a Metal Chelator

1980 • 159 citations

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

1978 • 149 citations

Superoxide dismutase and the oxygen enhancement of radiation lethality

1976 • 140 citations

Properties of electrophoretically homogeneous constitutive forms of liver microsomal cytochrome P-450.

1981 • 121 citations

Generation of hydrogen peroxide, superoxide and hydroxyl radicals during the oxidation of dihydroxyfumaric acid by peroxidase

1977 • 120 citations

Direct evidence for electron transfer from ferrous cytochrome b5 to the oxyferrous intermediate of liver microsomal cytochrome P-450 LM2.

1981 • 109 citations

On the significance of the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism

1982 • 108 citations

NADPH-dependent production of oxy radicals by purified components of the rat liver mixed function oxidase system. I. Oxidation of hydroxyl radical scavenging agents.

1983 • 104 citations

Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons

1981 • 86 citations

Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine

1983 • 86 citations

Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles

1980 • 84 citations

Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.

1980 • 83 citations

NADPH-dependent production of oxy radicals by purified components of the rat liver mixed function oxidase system. II. Role in microsomal oxidation of ethanol.

1983 • 82 citations

Protection of Post-irradiated Mice by Superoxide Dismutase

1976 • 80 citations

Drug metabolism in ethanol induced fatty liver

1970 • 78 citations

Incorporation of purified components of the rabbit liver microsomal hydroxylase system into phospholipid vesicles

1980 • 73 citations

Studies on Cytochrome α

1962 • 69 citations

The mechanism of cytochrome P-450-dependent oxidation of ethanol in reconstituted membrane vesicles.

1981 • 67 citations

Cytochrome b₅ as Electron Donor for Oxy‐cytochrome P‐450

1981 • 62 citations

Ethanol-induced cytochrome P-450: Catalytic activity after partial purification

1976 • 62 citations

Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver.

1983 • 61 citations

Effect of thiourea on microsomal oxidation alcohols and associated microsomal functions

1979 • 61 citations

Changes in the rat hepatic mixed function oxidase system associated with chronic ethanol vapor inhalation

1981 • 55 citations

Effect of a single oral dose of methanol, ethanol and propan-2-ol on the hepatic microsomal metabolism of foreign compounds in the rat

1975 • 47 citations

Protection against alloxan-induced diabetes in mice by the hydroxyl radical scavenger dimethylurea

1978 • 46 citations

Radiation-Induced Damage in T4 Bacteriophage: The Effect of Superoxide Radicals and Molecular Oxygen

1978 • 38 citations

Dimethylurea: A radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure

1980 • 37 citations

Aniline is hydroxylated by the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism

1982 • 34 citations

Influence of trace metals on alloxan cytotoxicity in pancreatic islets

1979 • 32 citations

Increase in hepatic microsomal ethanol oxidation by a single dose of ethanol.

1982 • 25 citations

Spectral and metabolic properties of liver microsomes from imidazole-pretreated rabbits

1982 • 21 citations

Adsorbed Oxygen Inhibition of Reactions of Hydrogen with Tungsten

1978 • 21 citations

Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver

1980 • 14 citations

Ethanol-Inducible Liver Cytochrome P-450 in the Rat: Relative Specificity for Ethanol Oxidation Activity in Vitro

1980 • 9 citations

Effect of ethanol and n-butanol on alloxan inhibition of glucose-induced insulin release in isolated pancreatic islets

1978 • 7 citations

Iron deposition in tissues.

1980 • 3 citations