Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASE

1951 • 1,369 citations

Polynuclear Aromatic Hydrocarbons

2007 • 624 citations

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

1979 • 401 citations

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

1978 • 380 citations

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase

1979 • 317 citations

Biochemical Distinctions between the Nuclear and Microsomal Membranes from Rat Hepatocytes

1971 • 141 citations

Benzo[ a ]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates

1977 • 134 citations

Studies on the electron transport system

1956 • 129 citations

Preferential induction of aryl hydroxylase activity in rat liver nuclear envelope by 3-methylcholanthrene

1973 • 112 citations

Nuclear aryl hydrocarbon hydroxylase and interaction of polycyclic hydrocarbons with nuclear components

1977 • 106 citations

[24] Genetic differences in microsomal electron transport: The Ah Locus

1978 • 99 citations

Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.

1978 • 87 citations

Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse.

1978 • 81 citations

Binding of metabolically activated benzo(a)pyrene to nuclear macromolecules.

1976 • 77 citations

Stereoelectronic factors in the solvolysis of bay region diol epoxides of polycyclic aromatic hydrocarbons

1978 • 74 citations

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.

1976 • 70 citations

Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.

1978 • 54 citations

Binding of polycyclic hydrocarbons to nuclear components in vitro

1976 • 50 citations

Hepatic cytochrome P-448 and epoxide hydrase: Enzymes of nuclear origin are immunochemically identical with those of microsomal origin

1979 • 50 citations

Epoxide hydrase and mixed-function oxidase activities of rat liver nuclear membranes

1979 • 45 citations

Nuclear metabolism of benzo(a)pyrene and of (±)-trans-7,8-dihydroxy-7,8,-dihydrobenzo(a)pyrene

1977 • 42 citations

Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers

1978 • 42 citations

Induction of the hepatic microsomal and nuclear cytochrome P-450 system by hexachlorobenzene, pentachlorophenol and trichlorophenol

1979 • 41 citations

[91] NADH-cytochrome b5 reductase

1967 • 36 citations

Characterization of Electron Transport Enzymes in the Envelope of Rat Liver Nuclei

1978 • 32 citations

Metabolism of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes.

1978 • 32 citations

Similarity of nuclear and microsomal cytochromes P-450 in the in vitro activation of aflatoxin B1

1979 • 28 citations

The role of microsomes and nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules.

1977 • 27 citations

Differences between nuclear and microsomal cytochrome P-450 in uninduced and induced rat liver.

1978 • 24 citations

metabolism of aflatoxin B1 by rat liver nuclei

1977 • 23 citations

Subcellular events occurring during aryl hydrocarbon hydroxylase induction: no requirement for metabolism of polycyclic hydrocarbon inducer.

1977 • 18 citations

Metabolism of 2-aminofluorene and 2-acetylaminofluorene to mutagens by rat hepatocyte nuclei.

1979 • 18 citations

Effects of different cell constituents on metabolic activation and binding of benzo(a)pyrene to purified and nuclear DNA

1979 • 15 citations

Intranuclear localization of hepatic cytochrome P448 by an immunochemical method.

1979 • 14 citations

Microsomal and nuclear metabolism of 3-methylcholanthrene

1979 • 14 citations

Activation of 2-acetylaminofluorene in the nuclei of rat liver.

1979 • 12 citations

Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei

1980 • 10 citations

Stereospecificity of metabolism of benzo[a]pyrene (BP) to (±)trans-7,8-dihydroxy-7,8-dihydro-BP by rat liver nuclear enzymes

1979 • 8 citations

Nuclear metabolism of polycyclic hydrocarbons and interaction of polycyclic hydrocarbons with nuclear components

1978 • 8 citations