Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Purification and properties

1975 • 1,733 citations

Unique Biosynthesis by Kidney of a Biologically Active Vitamin D Metabolite

1970 • 1,281 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

The Formation of Estrogens by Central Neuroendocrine Tissues

1975 • 794 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands

1972 • 661 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Biological Aromatization of Steroids

1959 • 596 citations

The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization

1974 • 587 citations

Microsomes and drug oxidation

1969 • 451 citations

Studies on ACTH action in perfused bovine adrenals: The site of action of ACTH in corticosteroidogenesis

1954 • 446 citations

Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase

1966 • 379 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

ESTRADIOL-17β BIOSYNTHESIS IN CULTURED GRANULOSA CELLS FROM HYPOPHYSECTOMIZED IMMATURE RATS; STIMULATION BY FOLLICLE-STIMULATING HORMONE¹¹

1975 • 323 citations

CONVERSION OF ANDROSTENEDIONE TO ESTRONE BY HUMAN FAT TISSUE

1972 • 317 citations

Inhibition of Human Estrogen Synthetase (Aromatase) by Flavones

1984 • 310 citations

Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).

1981 • 298 citations

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

1981 • 295 citations

Vitamin D Metabolism: The Role of Kidney Tissue

1971 • 293 citations

HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.

1984 • 291 citations

Follicle-stimulating hormone stimulates estradiol-17beta synthesis in cultured Sertoli cells.

1975 • 268 citations

Molecular endocrinology

1978 • 258 citations

Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.

1982 • 251 citations

Mitochondrial Cytochrome P450

1974 • 242 citations

Regulation of the hydroxylation of 25-hydroxyvitamin D3 in vivo and in primary cultures of chick kidney cells.

1979 • 213 citations

Multiple forms of hepatic cytochrome P-450. Purification, characterisation and comparison of a novel clofibrate-induced isozyme with other major forms of cytochrome P-450

1984 • 210 citations

The Cholesterol Side-Chain Cleavage System of Bovine Adrenal Cortex

1967 • 209 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

1977 • 201 citations

25-Hydroxyvitamin D₃-24-hydroxylase. Subcellular location and properties

1974 • 195 citations

THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.

1963 • 189 citations

Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex

1983 • 187 citations

Regulation of Metabolism of 25-Hydroxycholecalciferol by Kidney Tissue in vitro by Dietary Calcium

1972 • 183 citations

Adrenocorticotropin action in isolated adrenal cells. The intermediate role of cyclic AMP in stimulation of corticosterone synthesis.

1979 • 176 citations

The role of 1,25-dihydroxyvitamin D3 and parathyroid hormone in the regulation of chick renal 25-hydroxyvitamin D3-24-hydroxylase

1975 • 175 citations

ω-Oxidation of Long Chain Fatty Acids in Rat Liver

1964 • 175 citations

Induction of Testicular Aromatization by Luteinizing Hormone in Mature Rats*

1979 • 172 citations

Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation.

1980 • 171 citations

Metabolism of Prostaglandins

1977 • 170 citations

A neutral metallo endoprotease involved in the processing of an F1-ATPase subunit precursor in mitochondria.

1982 • 167 citations

Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes.

1980 • 165 citations

Mechanism of induction of cytochrome P-450 by phenobarbital.

1981 • 159 citations

Über das antirachitisch wirksame Bestrahlungsprodukt ans 7-Dehydro-cholesterin.

1936 • 159 citations

Characterization of corticotropin receptors on adrenocortical cells.

1981 • 156 citations

Cytochrome P-450 from Bovine Adrenocortical Mitochondria: an Enzyme for the Side Chain Cleavage of Cholesterol

1973 • 155 citations

Regulation of cytochrome P-450-supported 11 beta-hydroxylation of deoxycortisol by steroids, oxygen, and antioxidants in adrenocortical cell cultures.

1980 • 151 citations

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

1984 • 150 citations

Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid

1982 • 147 citations

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

1982 • 147 citations

Adrenal cells in tissue culture

1968 • 144 citations

Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells.

1979 • 144 citations

In vitro production of 1,25-dihydroxyvitamin D3 by rat placental tissue.

1979 • 138 citations

The oxidative metabolism of arachidonic acid by purified cytochromes P-450

1981 • 133 citations

Participation of the membrane in the side chain cleavage of cholesterol. Reconstitution of cytochrome P-450scc into phospholipid vesicles.

1979 • 131 citations

An iron protein as a component of steroid 11β-hydroxylase complex

1965 • 130 citations

Testicular microsomal cytochrome P-450 for C21 steroid side chain cleavage. Spectral and binding studies.

1981 • 130 citations

Microsomes and Drug Oxidations

1985 • 128 citations

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

1981 • 127 citations

Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)

1982 • 124 citations

The developmental changes in plasma adrenal androgens during infancy and adrenarche are associated with changing activities of adrenal microsomal 17-hydroxylase and 17,20-desmolase.

1981 • 122 citations

Properties of an adrenal cytochrome P-450 (P-45011) for the hydroxylations of corticosteroids

1978 • 122 citations

Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450.

1984 • 121 citations

Properties of electrophoretically homogeneous constitutive forms of liver microsomal cytochrome P-450.

1981 • 121 citations

The Metabolism of Vitamin D₃and 25-Hydroxyvitamin D₃in Normal and Anephric Humans

1974 • 121 citations

Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes.

1982 • 120 citations

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa

1977 • 119 citations

The Amino Acid Sequence of Bovine Adrenodoxin

1973 • 119 citations

Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.

1983 • 114 citations

Cytochrome P450K of rat kidney cortex microsomes: Its Involvement in fatty acid ω- and (ω-1)-hydroxylation

1972 • 114 citations

Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450

1979 • 114 citations

25-Hydroxyvitamin D3 26,23-lactone: a new in vivo metabolite of vitamin D

1979 • 112 citations

Cytochrome P-45011 beta and P-450scc in adrenal cortex: zonal distribution and intramitochondrial localization by the horseradish peroxidase-labeled antibody method.

1982 • 111 citations

Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells.

1981 • 111 citations

25-Hydroxycholecalciferol-1-hydroxylase: A specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria

1974 • 110 citations

NADPH-cytochrome c (P-450) reductase. Spectrophotometric and stopped flow kinetic studies on the formation of reduced flavoprotein intermediates.

1979 • 110 citations

LIFETIME OF ADRENAL CYTOCHROME P‐450 AS INFLUENCED BY ACTH*

1973 • 109 citations

Regulation of Aromatase Activity of Stromal Cells Derived from Human Adipose Tissue*

1982 • 108 citations

Cytochrome P-450 and steroid biosynthesis in the human placenta

1968 • 106 citations

Cloning and expression of cDNA encoding a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylation.

1984 • 105 citations

The Metabolic Basis of Inherited Disease

1983 • 105 citations

Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria.

1980 • 101 citations

Participation of a Nonenzymatic Transformation in the Biosynthesis of Estrogens from Androgens

1977 • 100 citations

The photobiogenesis and metabolism of vitamin D.

1978 • 100 citations

Human cytochromes P-450

1984 • 99 citations

Biosynthesis of 19‐Hydroxy‐Prostaglandin A₁

1969 • 99 citations

Induction of synthesis of mitochondrial steroidogenic enzymes of bovine adrenocortical cells by analogs of cyclic AMP.

1984 • 94 citations

Phosphatidylcholine vesicle reconstituted cytochrome P-450scc. Role of the membrane in control of activity and spin state of the cytochrome.

1980 • 94 citations

On the Fatty Acid and Hydrocarbon Hydroxylation in Rat Liver Microsomes

1968 • 94 citations

Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.

1981 • 94 citations

Studies on Adrenal Steroid Hydroxylases

1973 • 93 citations

Metabolism of C-16-oxygenated Steroids by Human Placenta: the Formation of Estriol

1959 • 93 citations

Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence.

1981 • 93 citations

The effect of hepatectomy on the synthesis of 25-hydroxyvitamin D3.

1976 • 93 citations

Purification of cytochrome P-450D1α (25-hydroxyvitamin D3-1α-hydroxylase) of bovine kidney mitochondria

1982 • 92 citations

Lifetime of microsomal cytochrome P-450 and steroidogenic enzymes in rat testis as influenced by human chorionic gonadotrophin

1973 • 92 citations

The Stoichiometry of the Conversion of Cholesterol and Hydroxycholesterols to Pregnenolone (3β-Hydroxypregn-5-en-20-one) Catalysed by Adrenal Cytochrome P -450

1974 • 90 citations

The purification and properties of NADPH‐adrenodoxin reductase from bovine adrenocortical mitochondria

1972 • 89 citations

Effects of Hypophysectomy and ACTH Administration on the Level of Adrenal Cholesterol Side-Chain Desmolase

1969 • 88 citations

FACTORS INFLUENCING THE INHIBITORY EFFECT OF CARBON MONOXIDE ON CYTOCHROME P‐450‐CATALYZED MIXED FUNCTION OXIDATION REACTIONS *

1970 • 87 citations

Participation of the microsomal electron transport system involving cytochrome P-450 in ω-oxidation of fatty acids

1968 • 87 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

ENZYMATIC SYNTHESIS OF 17-HYDROXYCORTICOSTERONE

1951 • 86 citations

The leukotrienes: a new group of biologically active compounds including SRS-A

1980 • 86 citations

Aldosterone biosynthesis by a reconstituted cytochrome P-45011β system

1984 • 82 citations

Composition and structure of camphor hydroxylase components and homology between putidaredoxin and adrenodoxin

1971 • 79 citations

Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.

1979 • 78 citations

Purification of cytochrome P-450 from bovine adrenocortical mitochondria by an “Aniline-sepharose” and the properties

1975 • 78 citations

Biochemical and Endocrine Properties of a Mechanism-Based Inhibitor of Aromatase

1984 • 78 citations

Purification and properties of 17α-hydroxylase from microsomes of pig adrenal: A scond C21side-chain cleavage system

1983 • 76 citations

Spectroscopic Studies on Spinach Ferredoxin and Adrenodoxin^*

1967 • 75 citations

Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells.

1981 • 75 citations

Cytochrome P-450 and the aromatization of 16α-hydroxytestosterone and androstenedione by human placental microsomes

1976 • 73 citations

Discriminatory processing of the precursor forms of cytochrome P-450scc and adrenodoxin by adrenocortical and heart mitochondria.

1984 • 73 citations

The 21-Hydroxylase Activity in the Glomerulosa and Fasciculata of the Adrenal Cortex in Congenital Adrenal Hyperplasia*

1981 • 72 citations

Effect of phenobarbital administration to rats on the level of the in vitro synthesis of cytochrome P-450 directed by total rat liver RNA

1979 • 72 citations

Partial resolution of the mixed-function oxidase involved in the cholesterol side-chain cleavage reaction in bovine adrenal mitochondria

1967 • 71 citations

FUNCTIONAL ZONATION OF THE ADRENAL CORTEX: PATHWAYS OF CORTICOSTEROID BIOGENESIS

1959 • 70 citations

Adrenodoxin reductase-adrenodexin complex.

1976 • 69 citations

Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogs

1982 • 69 citations

Production of 1,25-Dihydroxyvitamin D₃and Formation of Medullary Bone in the Egg-Laying Hen*

1979 • 68 citations

Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex

1982 • 67 citations

Adrenal Cells in Tissue Culture

1970 • 67 citations

Cytochrome P-450scc-adrenodoxin complex. Reduction properties of the substrate-associated cytochrome and relation of the reduction states of heme and iron-sulfur centers to association of the proteins.

1983 • 66 citations

omega-Oxidation of prostaglandins by lung and liver microsomes. Changes in enzyme activity induced by pregnancy, pseudopregnancy, and progesterone treatment.

1978 • 64 citations

Effects of adrenocorticotropin on 17 alpha-hydroxylase activity and cytochrome P-450(17 alpha) synthesis in bovine adrenocortical cells.

1985 • 62 citations

Structural gene products of the Ah complex. Increases in large mRNA from mouse liver associated with cytochrome P1-450 induction by 3-methylcholanthrene.

1981 • 62 citations

Similarity of responses of cultured sertoli cells to cholera toxin and FSH

1976 • 61 citations

Fatty acid inducible cytochrome P-454 of rat kidney cortex microsomes

1970 • 61 citations

Role of cytochrome b5 in the cytochrome P-450-mediated C21-steroid 17,20-lyase reaction

1982 • 61 citations

Cytochrome P450 in adrenocortical mitochondria

1979 • 60 citations

Intestinal synthesis of 24-keto-1,25-dihydroxyvitamin D3. A metabolite formed in vivo with high affinity for the vitamin D cytosolic receptor.

1983 • 60 citations

Regulation of cytochrome P-45011 beta gene expression by adrenocorticotropin.

1985 • 60 citations

Steroid 21-hydroxylase (cytochrome P-450) from porcine adrenocortical microsomes: microsequence analysis of cysteine-containing peptides

1983 • 59 citations

Induction of 11 beta-hydroxylase by corticotropin in primary cultures of bovine adrenocortical cells.

1983 • 58 citations

Effect of adrenocorticotropin on steroid 21-hydroxylase synthesis and activity in cultured bovine adrenocortical cells. Increased synthesis in the absence of increased activity.

1983 • 58 citations

Purification and properties of cytochrome P-450 (11β- and 18-hydroxylase) from bovine adrenocortical mitochondria

1977 • 57 citations

Relative contributions of α-, β-, and ω-oxidative pathways to in vitro fatty acid oxidation in rat liver

1968 • 57 citations

Stimulation of 1,25-dihydroxycholecalciferol production by prolactin and related peptides in intact renal cell preparations in vitro

1981 • 57 citations

Intraovarian mechanisms in the hormonal control of granulosa cell differentiation in rats

1983 • 57 citations

Distribution of the steroid 11‐β‐hydroxylase and the cytochrome P‐450 in membranes of beef adrenal cortex mitochondria

1969 • 56 citations

Characterization of the acute stimulation of steroidogenesis in primary bovine adrenal cortical cell cultures.

1984 • 54 citations

Regulation of 21-Hydroxylase Activity by Steroids in Cultured Bovine Adrenocortical Cells: Possible Significance for Adrenocortical Androgen Synthesis*

1982 • 51 citations

In vitro synthesis of adrenodoxin and adrenodoxin reductase: Existence of a putative large precursor form of adrenodoxin

1980 • 51 citations

Characterization of a specific, high affinity binding macromolecule for 1 alpha, 25-dihydroxyvitamin D3 in cultured chick kidney cells.

1980 • 50 citations

A mitochondrial electron carrier involved in steroid hydroxylations

1965 • 49 citations

Cholesterol Metabolism and Steroid-Hormone Production

1978 • 49 citations

Administration of 3-methylcholanthrene to rats increases the specific hybridizable mRNA coding for cytochrome P-450c.

1981 • 48 citations

Cleavage of Cholesterol Side Chain Associated with Cytochrome P-450, Flavoprotein, and Nonheme Iron-protein Derived from the Bovine Adrenal Cortex

1968 • 47 citations

Further Studies on the Submitochondrial Localization of Cholesterol Side Chain-cleaving Enzyme System in Hog Adrenal Cortex by Sonic Treatment*

1970 • 47 citations

Hydroxylation of prostaglandins A1 and E1 by liver microsomal monooxygenase. Characteristics of the enzyme system in the guinea pig.

1978 • 46 citations

Adrenal cells in tissue culture. III. Effect of adrenocorticotropin and 3',5'-cyclic adenosine monophosphate on 11.beta.-hydroxylase and other steroidogenic enzymes

1969 • 46 citations

Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin by follicle-stimulating hormone, 8-bromo-cyclic AMP, and low density lipoprotein in cultured bovine granulosa cells.

1984 • 45 citations

The mechanistic plurality of cytochrome P-450 and its biological ramifications

1984 • 45 citations

Synthesis of liver cytochrome P-450b in a cell-free protein synthesizing system

1979 • 44 citations

Adrenodoxin biosynthesis by bovine adrenal cells in monolayer culture. Induction by adrenocorticotropin.

1982 • 43 citations

Properties of bovine luteal cytochrome P-450scc incorporated into artificial phospholipid vesicles

1984 • 42 citations

At least six forms of extremely homologous cytochromes P-450 in rat liver are encoded at two closely linked genetic loci.

1983 • 41 citations

The Tissue Localization of Tritiated Parathyroid Hormone in Thyroparathyroidectomized Rats

1972 • 41 citations

Fatty Acid Interaction with the Hydroxylating Enzyme System of Rat Liver Microsomes

1969 • 41 citations

Studies on Corticotropin-Induced Desensitization of Normal Rat Adrenocortical Cells*

1983 • 40 citations

Adrenal Mitochondrial Cytochrome P-450 and Cholesterol Side Chain Cleavage Activity

1973 • 40 citations

Rabbit Hepatic Progesterone 21-Hydroxylase Exhibits a Bimodal Distribution of Activity

1982 • 40 citations

Properties of ferredoxin reductase and ferredoxin from the bovine corpus luteum

1984 • 39 citations

Bovine adrenocortical microsomal hemeproteins P-45017 alpha and P-450C-21. Isolation, partial characterization, and comparison to P-450SCC.

1982 • 38 citations

Partial resolution of the placental microsomal aromatase complex

1976 • 38 citations

Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side chain cleavage from bovine corpus luteum.

1980 • 38 citations

18‐Hydroxylation of Deoxycorticosterone by Reconstituted Systems from Rat and Bovine Adrenals

1975 • 37 citations

Regulation of steroidogenesis in rat leydig cells in culture: Effect of human chorionic gonadotropin and dibutyryl cyclic AMP on the synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin

1985 • 36 citations

Adrenal cortical cytochrome P-450. III. Effects of carbon monoxide and light on steroid 11β hydroxylation

1970 • 36 citations

Induction of 17α-hydroxylase (cytochrome P-45017α) activity by adrenocorticotropin in bovine adrenocortical cells maintained in monolayer culture

1983 • 36 citations

Physicochemical properties of reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from bovine adrenocortical microsomes

1979 • 36 citations

Luteinizing hormone and cyclic AMP-mediated induction of microsomal cytochrome P-450 enzymes in cultured mouse Leydig cells.

1984 • 34 citations

Regulation of aromatase activity of cultured adipose stromal cells by catecholamines and adrenocorticotropin

1984 • 34 citations

Inhibition of human placental mixed-function oxidations with carbon monoxide: Reversal with monochromatic light

1977 • 34 citations

Stimulation of cholesterol binding to steroid-free cytochrome P-450scc by poly(L-lysine). The implication in functions of labile protein factor for adrenocortical steroidogenesis.

1981 • 34 citations

Cholesterol Side-Chain Cleavage Activity in the Adrenal Gland of Young Rat: Development and Responsiveness to Adrenocorticotropic Hormone

1969 • 33 citations

A fatty acid gamma-hydroxylation system solubilized from porcine kidney cortex microsomes.

1971 • 33 citations

Studies on adrenal cortical cytochrome P-450

1968 • 32 citations

A fatty acid ω-hydroxylation system solubilized from porcine kidney cortex microsomes

1971 • 32 citations

Biosynthesis of Adrenodoxin in Mouse Adrenal Tumor Cells1¹

1976 • 32 citations

Studies on Adrenal Steroid Hydroxylases

1970 • 32 citations

Effects of ACTH on steroidogenesis in bovine adrenocortical cells in primary culture—increased secretion of 17α-hydroxylated steroids associated with a refractoriness in total steroid output

1983 • 31 citations

Modulation of 25-hydroxyvitamin D3-24-hydroxylase by aminophylline: A cytochrome P-450 monooxygenase system

1979 • 31 citations

Evidence for the presence of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin in fresh granulosa cells. Effects of follicle-stimulating hormone and cyclic AMP on cholesterol side chain cleavage cytochrome P-450 synthesis and activity.

1983 • 30 citations

Effects of phospholipid and detergent on the substrate specificity of adrenal cytochrome P-450scc. Substrate binding and kinetics of cholesterol side chain oxidation.

1981 • 29 citations

Steroid hydroxylase. Molecular properties of adrenal iron-sulfur protein

1969 • 29 citations

Properties of the aromatase system associated with the mitochondrial fraction of human placenta

1978 • 28 citations

Changes in some biochemical parameters including cytochrome P-450 after hypophysectomy and their restoration by acth administration in rats four months post hypophysectomy

1972 • 28 citations

Turnover of newly synthesized cytochromes P-450scc and P-45011β and adrenodoxin in bovine adrenocortical cells in monolayer culture: Effect of adrenocorticotropin

1984 • 27 citations

Enzymatic formation of (20R,22R)-20,22-dihydroxycholesterol from cholesterol and a mixture of 16O2 and 18O2: Random incorporation of oxygen atoms

1974 • 26 citations

The domain structure of the cholesterol side-chain cleavage cytochrome P-450 from bovine adrenocortical mitochondria

1984 • 25 citations

ω‐Oxidation of Branched‐Chain Fatty Acids in Rat Liver Homogenates

1970 • 24 citations

The role of the sugar regions of components of the cytochrome p-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria

1982 • 24 citations

Kinetic studies on substrate-enzyme interaction in the adrenal cholesterol side-chain cleavage system

1972 • 23 citations

Fate of molecular oxygen required by endocrine enzymes for the side-chain cleavage of cholesterol

1968 • 23 citations

Regulation of 18-Hydroxycorticosterone formation in bovine adrenocortical mitochondria

1983 • 23 citations

Dissection of cytochrome P-450 isozymes (RLM) from fractions of untreated rat liver microsomal proteins

1982 • 22 citations

Purification of cytochrome P-450 catalyzing 25-hydroxylation of vitamin D3 from rat liver microsomes

1984 • 22 citations

ACTH-mediated induction of synthesis and activity of cytochrome P-450s and related enzymes in cultured bovine adrenocortical cells

1982 • 22 citations

Induction of synthesis of bovine adrenocortical cytochromes P-450scc, P-45011β, P-450c21, and adrenodoxin by prostaglandins E2 and F2α and cholera toxin

1984 • 22 citations

Two Forms of Adrenodoxin Reductase from Mitochondria of Bovine Adrenal Cortex

1982 • 20 citations

Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal

1976 • 20 citations

Molecular cloning of DNA complementary to bovine adrenal P450scc mRNA

1984 • 20 citations

Failure to demonstrate stimulatory effect of prolactin on vitamin D metabolism in vitamin-D-deficient rats

1979 • 20 citations

ACTH-stimulated rabbit adrenal 17α-hydroxylase. Kinetic properties and a comparison with those of 3β-hydroxysteroid dehydrogenase

1978 • 19 citations

Aromatization of steroids by mitochondrial preparations from human term placenta

1978 • 18 citations

Molecular induction by phenobarbital of a rat hepatic form of cytochrome P-450: Expression of a 4-kilobase messenger RNA

1983 • 17 citations

The activity and biosynthesis of cholesterol side-chain cleavage enzyme in cultured immature pig testis cells

1984 • 17 citations

The apparent lack of stimulation of rabbit adrenal 21-hydroxylase activity by ACTH

1978 • 16 citations

Contributions of cytoplasmic free and membrane-bound ribosomes to the synthesis of mitochondrial cytochrome P-450(SCC) and P-450(11 beta) and microsomal cytochrome P-450(C-21) in bovine adrenal cortex.

1983 • 16 citations

The Aromatizing Activity of Placental Mitochondrial and Microsomal Fractions

1970 • 12 citations

Estrogen Synthetase Stimulation by Dibutyryl Cyclic Adenosine 3',5'-Monophosphate in Human Choriocarcinoma Cell Culture: The Relative Biosynthetic Rate of the Nicotinamide Adenine Dinucleotide Phosphate (Reduced Form)-Cytochrome c Reductase Component*

1982 • 9 citations

Regulation of Cytochrome P‐450₁₇α Activity and Synthesis in Bovine Adrenocortical Cells^a

1985 • 8 citations

Contributions of Cytoplasmic Free and Membrane-Bound Ribosomes to the Synthesis of NADPH-Adrenodoxin Reductase and Adrenodoxin of Bovine Adrenal Cortex Mitochondria<xref ref-type="fn" rid="fn1">¹</xref>

1983 • 8 citations

Amino acid composition of cytochrome P-450SCC from bovine corpus luteum

1982 • 4 citations

Mechanisms of induction of endogenous substrate oxidation

1985 • 2 citations