On the mechanism of prostacyclin and thromboxane A2 biosynthesis

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

The O-Dealkylation of 7-Ethoxycoumarin by Liver Microsomes. A Direct Fluorometric Test

1972 • 634 citations

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica

1980 • 615 citations

Chemical mechanisms of catalysis by cytochromes P-450: a unified view

1984 • 481 citations

Inhibitors of Cytochrome P-450s and Their Mechanism of Action

1981 • 396 citations

THE PROSTACYCLIN-THROMBOXANE A2 BALANCE: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS

1983 • 283 citations

Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation.

1983 • 205 citations

Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.

1985 • 194 citations

[59] Extraction and thin-layer chromatography of arachidonic acid metabolites

1982 • 162 citations

Synthesis and structure of the platelet aggregation factor thromboxane A2

1985 • 126 citations

Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach

1976 • 124 citations

Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein.

1983 • 118 citations

Metabolism of Prostaglandin E2 in Guinea Pig Liver

1970 • 117 citations

On the Hydroxylation of Cyclohexane in Rat Liver Microsomes

1969 • 101 citations

Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase

1981 • 100 citations

Cytochrome P450 and biological hydroxylation reactions

2005 • 98 citations

Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.

1986 • 68 citations

Models for ferric cytochrome P450. Characterization of hemin mercaptide complexes by electronic and ESR spectra

1979 • 68 citations

Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: Development of a novel enzyme assay

1987 • 64 citations

[15] Purification of bacterial cytochrome P-450

1978 • 63 citations

Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase

1987 • 62 citations

Prostacyclin and thromboxane synthase as P-450 enzymes

1984 • 55 citations

Synthesis of 13,14-dehydroprostacyclin methyl ester: a potent inhibitor of platelet aggregation.

1977 • 53 citations

Biosynthesis and biological actions of prostaglandins and thromboxanes

1982 • 51 citations

Spectral studies on structure-activity relationships of thromboxane synthesis inhibitors

1986 • 49 citations

Chemical and enzymic conversions of the prostaglandin endoperoxide PGH2.

1980 • 46 citations

Formation of 6-oxoprostaglandin F1 alpha, 6,15-dioxoprostaglandin F1 alpha, and monohydroxyicosatetraenoic acids from arachidonic acid by fetal calf aorta and ductus arteriosus.

1982 • 46 citations

Prostaglandin endoperoxides. 6. A polar transition state in the thermal rearrangement of 2,3-dioxabicyclo[2.2.1]heptane

1978 • 36 citations

Prostaglandin E2 — like activity and senile osteoporosis

1983 • 27 citations

Production of platelet thromboxane A2 inactivates purified human platelet thromboxane synthase

1986 • 25 citations

Thromboxane synthase catalyses hydroxylations of prostaglandin H₂ analogs in the presence of iodosylbenzene

1987 • 22 citations

Preparative hplc purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites

1987 • 21 citations

Fe(II)-induced decomposition of epidioxides. A chemical model for prostaglandin E, prostacyclin and thromboxane biosynthesis

1977 • 13 citations

Studies on the interaction of minoxidil with prostacyclin synthase in vitro

1988 • 13 citations

Biosynthesis of thromboxanes.

1980 • 10 citations

Synthesis of novel prostaglandin F2α isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide

1987 • 10 citations

An electron transfer model for PGI biosynthesis

1982 • 7 citations

11,12-Secoprostaglandin cyclization model in thromboxane A2 biosynthesis

1986 • 6 citations

The Chemistry of Cyclic Peroxides: The Formation and Decomposition of Prostaglandin Endoperoxide Analogs

1978 • 6 citations

An electron transfer model for thromboxane biosynthesis

1987 • 5 citations