The metabolic basis for combination chemotherapy

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Reporting results of cancer treatment

1981 • 7,916 citations

Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer

1977 • 1,526 citations

Adriamycin

1974 • 1,051 citations

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1979 • 912 citations

The importance of dose intensity in chemotherapy of metastatic breast cancer.

1984 • 882 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.

1976 • 820 citations

The Pharmacological Basis of Therapeutics.

1971 • 774 citations

MACOP-B Chemotherapy for the Treatment of Diffuse Large-Cell Lymphoma

1985 • 677 citations

High dose Cis-platinum diammine dichloride.Amelioration of renal toxicity by mannitol diuresis

1977 • 622 citations

Arabinosyl Cytosine: A Useful Agent in the Treatment of Acute Leukemia in Adults

1968 • 559 citations

Rationale for the use of alternating non-cross-resistant chemotherapy.

1982 • 545 citations

Comparison of the Sensitivity of Normal Hematopoietic and Transplanted Lymphoma Colony-Forming Cells to Chemotherapeutic Agents Administered <italic>In Vivo</italic><xref ref-type="fn" rid="FN2">2</xref>

1966 • 537 citations

Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study

1982 • 521 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

1968 • 477 citations

Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease.Clinical evaluation with special reference to childhood leukemia

1967 • 470 citations

Cancer: Principles and Practice of Oncology

1986 • 469 citations

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).

1973 • 430 citations

ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

1954 • 427 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Studies on Fluorinated Pyrimidines

1961 • 419 citations

On physico-chemical interactions between daunomycin and nucleic acids

1965 • 372 citations

Alternating Non-Cross-Resistant Combination Chemotherapy or MOPP in Stage IV Hodgkin's Disease

1986 • 370 citations

Correlation of cytotoxicity with incorporation of ara-C into DNA.

1980 • 362 citations

Handbook of experimental pharmacology

1973 • 345 citations

Studies on synchronous division of tissue culture cells initiated by excess thymidine

1964 • 342 citations

Fluorinated Pyrimidines and Their Nucleosides

1975 • 333 citations

The Mechanism of Action of Inhibitors of DNA Synthesis

1977 • 330 citations

VP-16 and cisplatin as first-line therapy for small-cell lung cancer.

1985 • 301 citations

Effects of Thymidine on Deoxyribonucleoside Triphosphate Pools and Deoxyribonucleic Acid Synthesis in Chinese Hamster Ovary Cells

1973 • 299 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate.

1970 • 290 citations

Treatment of Primary Breast Cancer with Chemotherapy and Tamoxifen

1981 • 289 citations

Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update

1983 • 279 citations

Comparison of in vitro methods to determine drug-induced cell lethality.

1976 • 278 citations

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.

1970 • 260 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

Growth Kinetics and Biochemical Regulation of Normal and Malignant Cells

1978 • 246 citations

Salvage Chemotherapy with ABVD in MOPP-Resistant Hodgkin's Disease

1982 • 240 citations

Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model.

1979 • 240 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

A Manual of Pharmacology and Its Applications to Therapeutics and Toxicology

1948 • 236 citations

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

1969 • 234 citations

Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.

1982 • 234 citations

The james ewing lecture. The relationship between tumor mass and resistance to chemotherapy. Implications for surgical adjuvant treatment of cancer

1983 • 230 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide

1972 • 213 citations

Treatment of adult acute leukemia with arabinosylcytosine and thioguanine

1969 • 211 citations

The pharmacological basis of therapeutics

1941 • 211 citations

Clonogenic and nonclonogenic in vitro chemosensitivity assays.

1985 • 208 citations

Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA.

1981 • 203 citations

Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis.

1978 • 197 citations

Advances in Chemotherapy of Cancer in Man

1956 • 193 citations

The Use of Drugs in Combination for the Treatment of Cancer

1973 • 193 citations

Synergistic interaction of anticancer agents: a cellular perspective.

1975 • 190 citations

Combination therapy of advanced head and neck cancer.Induction of remissions with diamminedichloroplatinum (II), bleomycin and radiation therapy

1978 • 190 citations

The Clinical Pharmacology of Antineoplastic Agents

1975 • 181 citations

L-Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies

1971 • 181 citations

A dose and time response analysis of the treatment of Hodgkin's disease with MOPP chemotherapy.

1983 • 181 citations

Terminology in the description of drug-radiation interactions

1979 • 177 citations

Chemical Suppression of the Immune Response

1962 • 177 citations

THE EFFECT OF 6-MERCAPTOPURINE ON PRIMARY AND SECONDARY IMMUNE RESPONSES *

1959 • 176 citations

Mechanism of action of cis-dichlorodiammineplatinum(II).

1979 • 173 citations

Childhood acute lymphocytic leukemia. Study VIII

1978 • 173 citations

Oxidative destruction of DNA by the adriamycin-iron complex

1984 • 173 citations

Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer

1977 • 169 citations

Pseudofeedback Inhibition of Purine Synthesis by 6-Mercaptopurine Ribonucleotide and Other Purine Analogues

1964 • 168 citations

Brief Communication: Therapy of Advanced Colorectal Cancer With a Combination of 5-Flourouracil, Methyl-l,3-cis(2-chlorethyl)-1-nitrosourea, and Vincristine2

1975 • 163 citations

Studies of cross-resistance, synergistic combinations and blocking of activity of platinum derivatives

1978 • 160 citations

Inhibition of Ribosomal Ribonucleic Acid Maturation in Novikoff Hepatoma Cells by 5-Fluorouracil and 5-Fluorouridine

1973 • 157 citations

THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

1963 • 156 citations

Cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells

1973 • 156 citations

Treatment of acute nonlymphocytic leukemia: use of anthracycline- cytosine arabinoside induction therapy and comparison of two maintenance regimens

1979 • 153 citations

cis-Dichlorodiammineplatinum(II) and VP-16-213: an active induction regimen for small cell carcinoma of the lung.

1979 • 153 citations

The use of tumor growth kinetics in planning "curative" chemotherapy of advanced solid tumors.

1969 • 149 citations

Nuclear and Cytoplasmic Pools of Deoxyribonucleoside Triphosphates in Chinese Hamster Ovary Cells

1974 • 145 citations

Etoposide (VP-16): Current Status and New Developments

1985 • 143 citations

Biological basis for the interaction of chemotherapeutic agents and radiation therapy

1985 • 142 citations

Cancer Chemotherapy Handbook

1981 • 141 citations

Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo

1967 • 141 citations

Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases.

1981 • 140 citations

Therapeutic response in phase I trials of antineoplastic agents.

1986 • 138 citations

The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.

1981 • 138 citations

5-Azacytidine: A New Active Agent for the Treatment of Acute Leukemia

1973 • 138 citations

Interaction of some daunomycin derivatives with deoxyribonucleic acid and their biological activity

1971 • 136 citations

Patterns of Resistance and Therapeutic Synergism among Alkylating Agents1

2015 • 133 citations

Clinical trials of cis-diamminedichloroplatinum (NSC-119875).

1973 • 133 citations

The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.

1978 • 133 citations

Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts.

1975 • 133 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

Purification and properties of 5-phosphoribosylpyrophosphate amidotransferase from adenocarcinoma 755 cells

1969 • 131 citations

Clinical Implications of Tumor-Cell Heterogeneity

1986 • 130 citations

On the Nature of a Sparing Effect by Thymidine on the Utilization of Deoxycytidine^*

1962 • 126 citations

The employment of combinations of drugs in the chemotherapy of neoplasia: a review.

1957 • 122 citations

Deoxycytidine Kinase

1970 • 122 citations

PYRIMIDINE METABOLISM

1957 • 122 citations

Response and survival in advanced breast cancer after two non-cross-resistant combinations.

1976 • 121 citations

Combination chemotherapy with cisplatin and etoposide in bronchogenic squamous cell carcinoma and adenocarcinoma. A study by the EORTC lung cancer working party (Belgium)

1982 • 120 citations

Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.

1980 • 119 citations

5-Fluorouracil incorporation in DNA of human breast carcinoma cells.

1982 • 117 citations

The Clinical Pharmacology of Antineoplastic Agents

1975 • 117 citations

Synergistic lethal effect of cis-dichlorodiammineplatinum and 1-beta-D-arabinofuranosylcytosine.

1981 • 115 citations

Treatment of acute nonlymphocytic leukemia: use of anthracycline- cytosine arabinoside induction therapy and comparison of two maintenance regimens

1979 • 115 citations

Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice.

1968 • 114 citations

Sarcomas of Soft Tissues

1963 • 113 citations

Studies of the enzymatic deamination of ara-cytidine—V

1968 • 113 citations

Chemistry of Guanine and Its Biologically Significant Derivatives

1968 • 112 citations

Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

1966 • 112 citations

Chemotherapy of acute lymphocytic leukemia of childhood

1972 • 111 citations

Chemotherapy of Metastatic Bladder Cancer

1980 • 110 citations

Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal adenocarcinoma HCT-8.

1981 • 109 citations

Sequential Blocking of Metabolic Pathways in vivo

1951 • 107 citations

Reduced formation of protein-associated DNA strand breaks in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 106 citations

Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine.

1974 • 105 citations

Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.

1976 • 105 citations

Chemotherapy of large bowel cancer.

1982 • 104 citations

Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.

1979 • 104 citations

Treatment of squamous-cell carcinoma of the head and neck with cisplatin and 5-fluorouracil.

1985 • 103 citations

5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA.

1981 • 103 citations

Clinical, biological, and biochemical effect of pyrazofurin.

1978 • 103 citations

Chemotherapy for stage III-IV epithelial ovarian cancer with cis-dichlorodiammineplatinum(II), adriamycin, and cyclophosphamide: a preliminary report.

1979 • 101 citations

Effect of diethyldithiocarbamate rescue on tumor response to cis-platinum in a rat model.

1980 • 101 citations

L-Asparaginase

1970 • 96 citations

Regulation of Enzymic Activity by Metabolites

1969 • 94 citations

Comparative studies of fluorinated pyrimidines with various cell lines.

1968 • 93 citations

Selective killing of transformed baby hamster kidney (BHK) cells.

1975 • 92 citations

Nitrosoureas: a review of experimental antitumor activity.

1976 • 91 citations

The prevention of methotrexate toxicity by thymidine infusions in humans.

1977 • 91 citations

Amino acid levels following L-asparagine amidohydrolase (EC.3.5.1.1) therapy.

1969 • 87 citations

An overview of thymidine

1980 • 87 citations

The effects of antibiotics and cancer chemotherapeutic agents on the cellular transport and antitumor activity of methotrexate in L1210 murine leukemia.

1973 • 86 citations

Synergism and potentiation with special reference to the combination of structural analogues.

1956 • 86 citations

DNA repair in primary cultures of rat hepatocytes.

1978 • 86 citations

Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine.

1982 • 86 citations

Combination sequential chemotherapy in advanced reticulum cell sarcoma

1972 • 86 citations

Combination clinical trials with thymidine and fluorouracil: A phase I and clinical pharmacologic evaluation

1980 • 85 citations

Asparagine Biosynthesis by the Novikoff Hepatoma

1968 • 85 citations

The adjuvant treatment of inoperable stage III and IV epidermoid carcinoma of the head and neck with platinum and bleomycin infusions prior to definitive radiotherapy: An RTOG pilot study

1980 • 85 citations

Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213

1975 • 85 citations

The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects

1975 • 84 citations

Characteristics of the Vincristine-induced Augmentation of Methotrexate Uptake in Ehrlich Ascites Tumor Cells

1973 • 82 citations

Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.

1970 • 80 citations

Acute Myelocytic Leukemia

1976 • 79 citations

Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

1980 • 79 citations

Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

1974 • 78 citations

Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU) RNA

1980 • 78 citations

Phenobarbital effects on cyclophosphamide pharmacokinetics in man.

1972 • 78 citations

Comparison of the sensitivity of hematopoietic colony-forming cells in different proliferative states to 5-fluorouracil.

1967 • 76 citations

Alanosine, a New Antiviral and Antitumour Agent isolated from a Streptomyces

1966 • 76 citations

Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells.

1979 • 75 citations

Pharmacologic Principles of Cancer Treatment

1983 • 75 citations

Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance.

1983 • 75 citations

THE MECHANISM OF ACTION OF 3‐DEAZAURIDINE IN TUMOR CELLS SENSITIVE AND RESISTANT TO ARABINOSYLCYTOSINE^*

1975 • 74 citations

Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.

1978 • 74 citations

Fluorouracil, methyl-ccnu and vincristine in cancer of the colon

1976 • 73 citations

Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice.

1977 • 73 citations

Integration of chemotherapy into combined modality treatment of solid tumors

1974 • 73 citations

Cyclophosphamide and CCNU in the treatment of inoperable small cell carcinoma and adenocarcinoma of the lung.

1976 • 72 citations

Antibiotic synergism and antagonism; an assessment of the problem.

1953 • 72 citations

Cyclophosphamide-adriamycin combination chemotherapy of transplantable murine tumors.

1975 • 71 citations

Methods of reduction of cisplatin nephrotoxicity.

1981 • 70 citations

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.

1970 • 70 citations

Methotrexate polyglutamate synthesis by cultured human breast cancer cells.

1980 • 70 citations

Combination chemotherapy in vitro with cis-dichlorodiammineplatinum(II).

1976 • 69 citations

Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.

1979 • 68 citations

Effect of delayed administration of citrovorum factor on the antileukemic effectiveness of aminopterin in mice.

1954 • 68 citations

Drug Synergism in Antineoplastic Chemotherapy

1964 • 67 citations

Thymidine rescue of high-dose methotrexate in humans.

1978 • 66 citations

In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine.

1977 • 66 citations

BIOCHEMICAL ASPECTS OF MERCAPTOPURINE INHBITION AND RESISTANCE.

1963 • 65 citations

The relevance of certain concepts of cell cycle kinetics

1978 • 65 citations

EFFECTS OF 6‐MERCAPTOPURINE AND ANALOGS ON EXPERIMENTAL TUMORS

1954 • 65 citations

Experimental therapeutics and kinetics: selection and overgrowth of specifically and permanently drug-resistant tumor cells.

1978 • 65 citations

Comparison of the Sensitivity of Hematopoietic Colony-Forming Cells in Different Proliferative States to Vinblastine<xref ref-type="fn" rid="FN2">2</xref>

1967 • 65 citations

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase

1981 • 64 citations

Interaction of aquated cis-diammineplatinum(II) with nucleic acid constituents. 1. Ribonucleosides

1977 • 63 citations

Nuclear envelope structure and RNA maturation

1985 • 63 citations

Alteration of methotrexate uptake in human leukemia cells by other agents.

1975 • 62 citations

Prevention of Toxicity of Amethopterin for Sarcoma-180 Cells in Tissue Culture

1957 • 61 citations

PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. 3. RELATIONSHIP OF THYMIDINE TO THE METABOLISM OF OTHER PYRIMIDINE NUCLEOSIDES IN SUSPENSION CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.

1965 • 61 citations

Effect of 5-fluorouracil on the synthesis and translation of polyadenylic acid-containing RNA from regenerating rat liver.

1979 • 60 citations

Enhancement of 1-beta-D-arabinofuranosylcytosine accumulation within L1210 cells and increased cytotoxicity following thymidine exposure.

1980 • 60 citations

Sequential methotrexate and 5-fluorouracil: improved response rate in metastatic colorectal cancer.

1984 • 59 citations

Metabolic effects of 6-thioguanine. I. Studies on thioguanine-resistant and-sensitive Ehrlich ascites cells.

1958 • 59 citations

Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines.

1980 • 59 citations

Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine.

1979 • 58 citations

Increased activation of 1-beta-D-arabinofuranosylcytosine by hydroxyurea in L1210 cells.

1980 • 58 citations

Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells

1969 • 58 citations

Enzymic ribosidation and ribotidation of 5-fluorouracil by extracts of the Ehrlich-ascites tumor

1958 • 58 citations

Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.

1979 • 57 citations

Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells.

1979 • 57 citations

The binding of vinblastine to tubulin and to particulate fractions of mammalian brain.

1974 • 57 citations

Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer.

1982 • 57 citations

A controlled study in the use of combined drug therapy for metastatic breast cancer

1975 • 56 citations

Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus.

1974 • 56 citations

Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate.

1984 • 56 citations

Selective lethal effect of thymidine on human and mouse tumor cells

1977 • 55 citations

Interaction of drugs inhibiting different steps in the synthesis of DNA.

1972 • 55 citations

cis-Dichlorodiammineplatinum(II) alone followed by adriamycin plus cyclophosphamide at progression versus cis-dichlorodiammineplatinum(II), adriamycin, and cyclophosphamide in combination for adenocarcinoma of the lung.

1978 • 55 citations

Combination chemotherapy with 4′Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-β-d-glucopyranoside), VP 16–213 (NSC 141540) in L1210 Leukemia

1976 • 52 citations

Different survival of normal and transformed cells exposed to nutritional conditions nonpermissive for growth.

1977 • 52 citations

Approaches to the Combination Chemotherapy of Transplantable Neoplasms

2015 • 52 citations

Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy

1978 • 51 citations

Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer

1962 • 51 citations

Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.

1969 • 50 citations

Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas.

1957 • 50 citations

Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.

1983 • 50 citations

Role of iron in adriamycin biochemistry.

1986 • 50 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response

1978 • 49 citations

Toxicology and pharmacology of the nitrosoureas.

1973 • 49 citations

Inhibition by N-(Phosphonacetyl)-l-Aspartate of Aspartate Transcarbamylase Activity and Drug-induced Cell Proliferation in Mice

1974 • 49 citations

Attempts at dual blocking of biochemical events in cancer chemotherapy.

1954 • 48 citations

Anabolic transformation of a novel antimetabolite, 5-azacytidine, and evidence for its incorporation into ribonucleic acid

1965 • 47 citations

An effective low-dose intermittent cyclophosphamide, methotrexate, and 5-fluorouracil treatment regimen for metastatic breast cancer

1975 • 47 citations

Mode of action of alanosine

1968 • 47 citations

The treatment of histiocytic lymphoma.

1980 • 47 citations

Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.

1972 • 47 citations

Combination chemotherapy with cytosine arabinoside and rubidomycin in 30 cases of acute granulocytic leukemia

1973 • 46 citations

Synergistic effect of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside on the levels of adenine nucleotides of Sarcoma 180 cells.

1972 • 46 citations

Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210.

1981 • 46 citations

Success and failure in the treatment of solid tumors. II. Kinetic parameters and "cell cure" of moderately advanced carcinoma 755.

1969 • 46 citations

Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro.

1983 • 45 citations

Toxicity of combinations of arabinosylcytosine and 3-deazauridine toward neoplastic cells in culture

1978 • 45 citations

Effect of thymidine on the toxicity, antitumor activity, and metabolism of 1-beta-D-arabinofuranosylcytosine in rats bearing a chemically induced colon carcinoma.

1980 • 45 citations

Reaction mechanism of aspartate transcarbamylase from mouse spleen

1974 • 44 citations

Synchronization in tumour chemotherapy

1976 • 44 citations

Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine.

1979 • 43 citations

Feedback inhibition of purine biosynthesis in ascites tumor cells by purine analogues

1963 • 43 citations

Inhibition of ribosomal RNA maturation in Novikoff hepatoma cells by toyocamycin, tubercidin, and 6-thioguanosine.

1974 • 43 citations

Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.

1983 • 42 citations

Biochemical and cytokinetic modulation of L1210 and HL-60 cells by hydroxyurea and effect on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity.

1983 • 42 citations

Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance.

1960 • 42 citations

High-dose daunorubicin therapy for acute nonlymphocytic leukemia: Correlation of response and toxicity with pharmacokinetics and intracellular daunorubicin reductase activity

1972 • 41 citations

Biochemical modulation: application of laboratory models to the clinic.

1986 • 41 citations

Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells.

1979 • 41 citations

The Partial Purification and Properties of Uridine Kinase from Ehrlich Ascites Tumor Cells

1973 • 40 citations

Preliminary report on the efficacy of sequential methotrexate and 5-fluorouracil in advanced breast cancer

1981 • 40 citations

Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase.

1980 • 40 citations

Unresolved issues in combination chemotherapy.

1986 • 39 citations

Combination therapy with methotrexate and 5-fluorouracil: a prospective randomized clinical trial of order of administration.

1984 • 39 citations

Successful treatment of metastatic sarcomas with cyclophosphamide, adriamycin, and DTIC (CAD)

1980 • 39 citations

Studies on the mode of action of 3-deazapyrimidines—1

1972 • 39 citations

The enhanced cytotoxicity of combinations of 1-beta-D-arabinofuranosylcytosine and methotrexate.

1975 • 39 citations

The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.

1979 • 39 citations

In Vivo Enhancement of 5-Fluorouracil Cytotoxicity to AKR Leukemia Cells by Thymidine in Mice<xref ref-type="fn" rid="FN2">2</xref>

1978 • 39 citations

Evidence for multidrug-resistant cells in human tumor cell populations.

1983 • 39 citations

Adrenal and Endocrine Tumors in Children

1983 • 38 citations

Synergistic Action of Cyclophosphamide and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea on a Transplanted Murine Lymphoma<xref ref-type="fn" rid="FN2">2</xref>

1968 • 38 citations

Modifications in biochemical pathways produced by the Vinca alkaloids.

1968 • 38 citations

Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.

1984 • 38 citations

Etoposide (VP-16) and cisplatin in previously treated small-cell lung cancer: clinical trial and in vitro correlates.

1986 • 37 citations

Mechanism of the growth inhibition potentiation arising from combination of 6-mercaptopurine with 6-(methylmercapto)purine ribonucleoside.

1970 • 37 citations

Decreased feedback inhibition in a 6-(methylmercapto)purine ribonucleoside-resistant tumor.

1967 • 37 citations

Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil.

1980 • 36 citations

A Manual of Pharmacology and Its Application to Therapeutics and Toxicology

1948 • 36 citations

5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced colorectal cancer: phase II study utilizing weekly 5-FU.

1976 • 36 citations

Rational basis for chemotherapy

1984 • 35 citations

Daunorubicin (NSC 82151) in the treatment of advanced childhood lymphoblastic leukemia.

1971 • 35 citations

5-fluorouracil and methotrexate combination chemotherapy: The effect of drug scheduling

1981 • 35 citations

Postreplication Repair of Ultraviolet Damage to DNA, DNA-Chain Elongation, and Effects of Metabolic Inhibitors in Mouse L Cells

1975 • 34 citations

Combination chemotherapy--theory and practice.

1977 • 33 citations

Clinical development of anticancer agents--a National Cancer Institute perspective.

1984 • 33 citations

Phase II study of cyclophosphamide, adriamycin, and cis-dichlorodiammineplatinum (II) by infusion in patients with adenocarcinoma and large cell carcinoma of the lung.

1979 • 32 citations

SCHEDULE-DEPENDENT SYNERGISM AND ANTAGONISM BETWEEN METHOTREXATE AND ASPARAGINASE

1975 • 32 citations

CMF versus CMF plus tamoxifen in advanced breast cancer in postmenopausal women. An EORTC trial.

1980 • 31 citations

Aspects on the Mode of Action of Antiestrogens and Antiprogestogens

1972 • 31 citations

Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.

1978 • 31 citations

Synergistic and antagonistic interactions of methotrexate and 1-β-D-arabinofuranosylcytosine in hepatoma cells

1981 • 31 citations

Combination chemotherapy: The antagonism of methotrexate and cytosine arabinoside

1973 • 31 citations

Effectiveness of intermediate-dose methotrexate and high-dose 5-fluorouracil as sequential combination chemotherapy in refractory breast cancer and as primary therapy in metastatic adenocarcinoma of the colon.

1980 • 30 citations

Uridine and cytidine metabolism following inhibition of de novo pyrimidine synthesis by pyrazofurin

1980 • 30 citations

Sequential methotrexate and 5-FU in the treatment of colorectal cancer.

1982 • 30 citations

Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity

1981 • 30 citations

Phase I study of 6-diazo-5-oxo-L-norleucine (DON).

1980 • 29 citations

Effect of excess thymidine on the growth of human melanoma cells transplanted in thymus deficient nude mice

1977 • 29 citations

Chemotherapy of advanced L1210 leukemia with platinum compounds in combination with other antitumor agents.

1977 • 29 citations

Site of Action of Cytotoxic Agents in the Cell Life Cycle

1974 • 28 citations

Antiproliferative agents and differential survival between normal and cancer cells.

1978 • 28 citations

Interaction of l-alanosine (NSC 153, 353) with enzymes metabolizing l-aspartic acid, l-glutamic acid and their amides

1980 • 28 citations

The effect of 5-fluorouridine 5'-triphosphate on RNA transcribed in isolated nuclei in vitro.

1980 • 28 citations

Inhibition of NADH-linked respiration with the anti-cancer agent 4′-demethyl-epipodophyllotoxin thenylidene glucoside (VM-26)

1972 • 28 citations

Enhancement of the antiproliferative action of 1- -D-arabinofuranosylcytosine by methotrexate in murine leukemic cells (L5178Y).

1973 • 28 citations

Combination chemotherapy in vitro. IV. Response of human colon carcinoma cells to combinations using cis-diamminedichloroplatinum.

1979 • 28 citations

Oral and parenteral activity of 2,2'-anhydro-1- -D-arabinofuranosyl-5-fluorocytosine against both intraperitoneally and intracerebrally inoculated mouse leukemia.

1972 • 27 citations

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days.

1975 • 26 citations

Clinical phase I-II and pharmacokinetic study of high-dose thymidine given by continuous intravenous infusion.

1980 • 26 citations

Chemotherapy for colorectal cancer with a combination of PALA and 5-FU.

1981 • 25 citations

Dose-related synergism of cytosine arabinoside and methotrexate against murine leukemia L1210

1974 • 25 citations

The role of cell kinetics in cancer chemotherapy.

1977 • 25 citations

Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178Y) mice.

1973 • 25 citations

Metabolites of alanosine, an antitumor antibiotic

1979 • 24 citations

Dual effect of 5-azacytidine on the synthesis of liver ribonucleic acids

1972 • 24 citations

Phase I and pharmacokinetic studies of DON.

1981 • 24 citations

Enhancement of 6-thioguanine cytotoxic activity with methotrexate

1982 • 24 citations

Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.

1982 • 23 citations

Combination chemotherapy: synergistic inhibition of lymphoma L5178Y cells in culture and in vivo with 6-mercaptopurine and 6-(methylmercapto)purine ribonucleoside.

1969 • 23 citations

Etoposide and cis-platinum in non-small-cell bronchogenic carcinoma

1982 • 23 citations

Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man.

1977 • 23 citations

Randomized study comparing doxorubicin, cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (ACOMLA) with cyclophosphamide, doxorubicin, vincristine, prednisone, and bleomycin (CHOP-B) in the treatment of diffuse histiocytic lymphoma.

1982 • 23 citations

Initial clinical study with N-(phosphonacetyl)-L-aspartic acid (PALA) in patients with advanced cancer.

1980 • 22 citations

Striking augmentation of the in vivo anti-cancer activity of 5-fluorouracil (fu) by combination with pyrimidine nucleosides. An rna effect. Abstr.

1978 • 22 citations

Cytidine and deoxycytidylate deaminase inhibition by uridine analogs

1980 • 21 citations

Advances in Rational Combination Chemotherapy

1986 • 21 citations

Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response.

1985 • 21 citations

EXPERIMENTAL AND CLINICAL STUDIES ON NUCLEOSIDE ANALOGS AS ANTITUMOR AGENTS^*

1975 • 21 citations

Incorporation of 5-azacytidine-4-[14C] and of cytidine-[3H] into ribonucleic acids of mouse Ehrlich ascites tumour cells

1966 • 21 citations

BLOOD PLASMA PROTEINS IN PATIENTS WITH HEART FAILURE

1946 • 20 citations

The incorporation of 6-thioguanine into RNA fractions and its effect on RNA and protein biosynthesis in mouse sarcoma 180 ascites cells.

1973 • 20 citations

Phase II study of sequential methotrexate-5-FU therapy in advanced measurable colorectal cancer.

1982 • 20 citations

Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in "spontaneous" and "transplantable" mammary tumors.

1978 • 19 citations

Use of methotrexate and 5-FU for recurrent head and neck cancer.

1982 • 19 citations

Transformation of 5-aza-2′-deoxycytidine-3H and its incorporation in different systems of rapidly proliferating cells

1978 • 18 citations

Combination Chemotherapy: Basic Considerations

1974 • 18 citations

Effects of A-methopterin on the purine biosynthesis of susceptible and resistant TA3 ascites cells.

1958 • 18 citations

Sequential methotrexate–5-fluorouracil treatment of squamous cell carcinoma of the head and neck

1983 • 18 citations

Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.

1977 • 18 citations

Phase I-Phase II Trial of <italic>N</italic>-Phosphonacetyl-<sc>l</sc>-Aspartic Acid Given by Intravenous Infusion and 5-Fluorouracil Given by Bolus Injection<xref ref-type="fn" rid="FN2">2</xref>

1982 • 18 citations

CELLULAR HETEROGENEITY IN MALIGNANT NEOPLASMS AND THE THERAPY OF METASTASES

1982 • 18 citations

5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia

1984 • 18 citations

Success and failure in present chemotherapy and the implications of asparaginase.

1969 • 18 citations

Schedule-dependent synergism of combinations of hydroxyurea with adriamycin and 1-beta-D-arabinofuranosylcytosine with adriamycin.

1981 • 17 citations

Methotrexate-induced Changes in the Levels of 1-β-d-Arabinofuranosylcytosine Triphosphate in L1210 Cells

1979 • 17 citations

Aspartate carbamoyltrasferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate

1982 • 17 citations

Sequential chemotherapy of advanced colorectal cancer with standard or high‐dose methotrexate followed by 5‐fluorouracil

1982 • 17 citations

Clinical use of methotrexate--with emphasis on use of high doses.

1981 • 16 citations

Effects of 6-thioguanine on macromolecular events in regenerating rat liver.

1977 • 15 citations

Distribution of [3H]cytosine arabinoside and its products in mice, dogs, and monkeys and effect of tetrahydrouridine.

1977 • 15 citations

Thymidine as a kinetic and biochemical modulator of 1-beta-D-arabinofuranosylcytosine in human acute nonlymphocytic leukemia.

1984 • 15 citations

Delayed pyridine nucleotide reoxidation induced by the anticancer agent VM-26 as measured in vivo and in situ by NADH microfluorimetry

1975 • 14 citations

INTERACTION OF METHOTREXATE AND CYTOSINE ARABINOSIDE

1972 • 14 citations

Thymidine (tdr) enhancement of antitumor activity of 5-fluorouracil (fu) against advanced murine (cd8f1) breast carcinoma. Abstr.

1977 • 13 citations

Combination therapy of animal tumors with L-asparaginase and antagonists of glutamine or glutamic acid.

1970 • 13 citations

Phase I study of L-alanosine (NSC 15353)

1983 • 13 citations

A phase II study of sequential methotrexate and fluorouracil in advanced colorectal cancer

1985 • 13 citations

Differential effect of N-(phosphonacetyl)-L-aspartate on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in human leukemia and normal bone marrow progenitors.

1982 • 12 citations

Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors.

1977 • 12 citations

Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.

1984 • 12 citations

Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.

1981 • 12 citations

Doxifluridine (5?-dFUrd) in patients with advanced colorectal carcinoma

1985 • 12 citations

Tamoxifen and 5-fluorouracil in breast cancer: modulation of cellular RNA.

1983 • 11 citations

Acute myelocytic leukemia

1976 • 11 citations

Differential response of two derivatives of the BHK21 hamster cell to thymidine

1967 • 11 citations

Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts.

1980 • 11 citations

Phase I study of continuous-infusion PALA and 5-FU.

1984 • 11 citations

Phase I study of L-alanosine using a daily x 3 schedule.

1982 • 10 citations

Cell synchronization in vivo: fact or fancy

1976 • 10 citations

Randomized multicenter trial of sequential methotrexate (MTX) and 5-Fluorouracil (FU) vs FU alone in metastatic colorectal carcinoma (CRC)

1986 • 10 citations

Treatment of murine tumors with 5-fluorouracil in combination with de novo pyrimidine synthesis inhibitors pala or pyrazofurin. Abstr.

1980 • 10 citations

Antagonism of the anti-tumour effects of asparaginase by methotrexate

1970 • 9 citations

Schedule-dependent synergistic cytotoxicity of arabinofuranosylcytosine with adriamycin or 3,6-bis(5-chloro-2-piperidinyl)-2,5-piperazinedione in cultured cells.

1975 • 9 citations

Inhibitors of L-asparagine synthetase, in vitro.

1976 • 9 citations

Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues

1982 • 9 citations

Combinations of 6-mercaptopurine (NSC-755) and 6-(methylmercapto)purine ribonucleoside (NSC-40774) in therapy of Ehrlich ascites carcinoma.

1967 • 9 citations

Sequence-dependent synergism between dichloromethotrexate and cisplatin in a human colon carcinoma cell line.

1985 • 9 citations

Chemistry of Alkylation

1975 • 8 citations

Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.

1982 • 8 citations

Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210.

1971 • 8 citations

The effect of the sequence of administration of cytoxan and methotrexate on the life-span of L1210 leukemic mice.

1972 • 7 citations

Enhanced response of leukemic (L1210) mice to combination chemotherapy with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC-45388) and 5-fluorouracil (NSC-19893)

1971 • 7 citations

Antibiotics, vol. VI: Modes and mechanisms of microbial growth inhibitors

1985 • 7 citations

In Vitro Assay for Sensitivity to Anticancer Drugs

1985 • 6 citations

Timed sequential chemotherapy following drug-induced kinetic recruitment in refractory ovarian cancer

1984 • 6 citations

Phase II study of sequential methotrexate and 5-FU plus mitomycin and leucovorin in patients with disseminated large bowel cancer: a Northern California Oncology Group study.

1984 • 6 citations

Methotrexate-induced changes in the levels of 1-beta-D-arabinofuranosylcytosine triphosphate in L1210 cells.

1979 • 5 citations

Augmentation of intracellular cytosine arabinoside accumulation and effect by thymidine in l1210 cells. Abstr.

1979 • 5 citations

Single versus combination chemotherapy of L1210 leukemia.

1980 • 5 citations

Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine

1983 • 4 citations

A quantitative microdensitometric and autoradiographic study of the effect of 4?-demethyl-epipodophyllotoxin-?-D-thenylidene glucoside (VM-26) on the cell cycle of cultured fibroblasts

1979 • 4 citations

Antitumor activity of pyrazofurin in combination with 5-azacytidine against murine P388 and L1210 leukemias and colon carcinoma 26.

1979 • 3 citations

Combination chemotherapy with l-asparaginase (nsc 109,229) and cyclophosphamide (nsc 26,271, cytoxan) in mice bearing leukemia l5178y. Abstr.

1970 • 3 citations

Biochemical Modulation as a Guide to Rational Combination Chemotherapy for the Treatment of Cancer

1983 • 3 citations

Effects of n-(phosphonacetyl)-l-aspartate (pala) on circulating pyrimidine nucleosides, nucleotide pools, and nucleic acid synthesis. Abstr.

1980 • 3 citations

THE USE OF 6‐MERCAPTOPURINE IN ACUTE LEUKEMIA

1954 • 3 citations

BIOCHEMICAL AND PHARMACOLOGICAL PRINCIPLES OF COMBINATION CHEMOTHERAPY

1975 • 3 citations

Alterations in messenger RNA and small nuclear RNA metabolism resulting from fluorouracil incorporation

1985 • 3 citations

Phase I evaluation of a biochemically designed combination: PALA, thymidine, and 5-FU.

1984 • 3 citations

Cellular transport and antitumor activity of methotrexate (mtx) in combination with clinically useful drugs. Abstr.

1972 • 3 citations

Advances in Chemotherapy

1963 • 2 citations

Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination.

1985 • 2 citations

Potentiation of 6-thioguanine intracellular accumulation and cytotoxicity by methotrexate in L1210 cells

1982 • 1 citations

Deleted Work

1955 • 0 citations