Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

1984 • 1,050 citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

1985 • 310 citations

Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.

1987 • 217 citations

Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

1982 • 180 citations

Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase.

1979 • 162 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Acetylation of Prostaglandin Endoperoxide Synthetase with Acetylsalicylic Acid

1980 • 158 citations

A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies.

1980 • 128 citations

Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol

1984 • 119 citations

Prostaglandin H synthase. Stoichiometry of heme cofactor.

1984 • 118 citations

Structural characteristics of prostaglandin synthetase from sheep vesicular gland.

1980 • 103 citations

Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450.

1987 • 103 citations

Accelerative autoactivation of prostaglandin biosynthesis by PGG2

1978 • 98 citations

Acetaminophen: enzymatic formation of a transient phenoxyl free radical

1984 • 91 citations

Metabolic oxidation of acetaminophen (Paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney

1981 • 90 citations

Xenobiotic Metabolism by Prostaglandin Endoperoxide Synthetase

1983 • 88 citations

Prostaglandin synthetase catalyzed activation of paracetamol

1982 • 85 citations

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

1980 • 84 citations

Peroxidase-mediated formation of reactive metabolites of acetaminophen.

1981 • 80 citations

The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase.

1987 • 80 citations

Metabolism of paracetamol to a glutathione conjugate catalyzed by prostaglandin synthetase

1980 • 74 citations

Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes.

1981 • 67 citations

The effect of 4-acetamidophenol on prostaglandin synthetase activity in bovine and ram seminal vesicle microsomes

1978 • 58 citations

Titration Study of Guaiarcol Oxidation by Horseradish Peroxidase

1975 • 48 citations

Tissue selectivity and variability of effects of acetaminophen on arachidonic acid metabolism

1983 • 44 citations

Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis.

1980 • 41 citations

Mechanism of inhibition of renal prostaglandin production by acetaminophen.

1979 • 40 citations

Prostaglandin H synthase: An example of enzymic symbiosis

1985 • 37 citations

Hydroperoxide-Dependent Oxidations during Prostaglandin Biosynthesis

1984 • 36 citations

Spectral intermediates of prostaglandin hydroperoxidase

1984 • 32 citations

Stable free radical and benzoquinone imine metabolites of an acetaminophen analogue.

1984 • 31 citations

Prostaglandin Endoperoxide Synthase-Catalyzed Oxidation Reactions

1984 • 21 citations

The mechanism of oxygen activation involved in the prostaglandin synthetase mechanism

1981 • 8 citations

The inhibitory effect of paracetamol on the electrically stimulated ileum of the guinea-pig

1981 • 7 citations

Mechanism of oxygen activation involved in the prostaglandin synthetase mechanism.

1980 • 7 citations