Chemical Mutation of Enzyme Active Sites

Kinetics and Mechanism of Action of Glucose Oxidase

1964 • 532 citations

Conversion of a protein to a homogeneous asymmetric hydrogenation catalyst by site-specific modification with a diphosphinerhodium(I) moiety

1978 • 528 citations

Structure of Papain

1968 • 473 citations

Binding of chloromethyl ketone substrate analogs to crystalline papain

1976 • 352 citations

The Structure of Papain

1971 • 242 citations

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".

1966 • 190 citations

A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin¹

1966 • 176 citations

ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY

1966 • 149 citations

Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi

1977 • 111 citations

14 Papain and Other Plant Sulfhydryl Proteolytic Enzymes

1971 • 106 citations

Oxidation of dihydronicotinamides by flavopapain

1978 • 91 citations

Determination of the hydride transfer stereospecificity of nicotinamide adenine dinucleotide linked oxidoreductases by proton magnetic resonance

1976 • 87 citations

Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue.

1982 • 84 citations

Properties of Thiol-Subtilisin

1968 • 80 citations

Oxidation of thiophenol and nitroalkanes by an electron deficient isoalloxazine

1975 • 77 citations

Flavopapain: Synthesis and properties of semi-synthetic enzymes

1977 • 68 citations

Mechanism of the reaction of dithiols with flavins

1975 • 62 citations

Reinvestigation of NADH analog redox reactions in acetonitrile: consequences of isotope scrambling on kinetic and product isotope effects

1982 • 48 citations

Thioltrypsin

1977 • 45 citations

Semisynthetic enzymes: characterization of isomeric flavopapains with widely different catalytic efficiencies

1984 • 41 citations

Conversion of the Active‐Site Cysteine Residue of Papain into a Dehydro‐serine, a Serine and a Glycine Residue

1978 • 37 citations

Stereospecificity in the oxidation of NADH by flavopapain

1980 • 33 citations

Semisynthetic enzymes: synthesis of a new flavopapain with high catalytic efficiency

1981 • 26 citations

Oxidation of dithiols by flavopapain

1981 • 20 citations

Enzyme-like Synthetic Catalysts (Synzymes)

1980 • 19 citations

Studies on the Mechanism of Action and Stereochemical Behavior of Semisynthetic Model Enzymes

1980 • 16 citations

Simulated Mutation at the Active Site of Biologically Active Proteins

1970 • 13 citations

Oxidation of dihydronicotinamides by flavin in enzyme and model reactions. Old yellow enzyme and lumiflavin.

1980 • 8 citations

ChemInform Abstract: OXIDATION OF DITHIOLS BY FLAVOPAPAIN

1981 • 6 citations