Nuclear Activation of Polycyclic Hydrocarbons

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

1976 • 483 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity

1978 • 271 citations

Biochemical Distinctions between the Nuclear and Microsomal Membranes from Rat Hepatocytes

1971 • 141 citations

Preferential induction of aryl hydroxylase activity in rat liver nuclear envelope by 3-methylcholanthrene

1973 • 112 citations

Nuclear aryl hydrocarbon hydroxylase and interaction of polycyclic hydrocarbons with nuclear components

1977 • 106 citations

3-Methylcholanthrene-inducible binding of aromatic hydrocarbons to DNA in purified rat liver nuclei

1974 • 93 citations

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.

1976 • 70 citations

Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomes

1976 • 60 citations

Binding of polycyclic hydrocarbons to nuclear components in vitro

1976 • 50 citations

Hepatic cytochrome P-448 and epoxide hydrase: Enzymes of nuclear origin are immunochemically identical with those of microsomal origin

1979 • 50 citations

Nuclear metabolism of benzo(a)pyrene and of (±)-trans-7,8-dihydroxy-7,8,-dihydrobenzo(a)pyrene

1977 • 42 citations

The ontogeny of nuclear aryl hydrocarbon hydroxylase

1978 • 20 citations