The P450 Gene Superfamily: Recommended Nomenclature

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Biochemical Evolution

1977 • 1,283 citations

Structure of human steroid 21-hydroxylase genes.

1986 • 568 citations

Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.

1986 • 559 citations

Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues

1988 • 452 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

On the antiquity of introns

1986 • 324 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

Genes for Cytochrome P-450 and Their Regulatio

1986 • 227 citations

Nucleotide sequence of the Pseudomonas putida cytochrome P-450cam gene and its expression in Escherichia coli.

1986 • 225 citations

Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls

1982 • 217 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Molecular and clinical advances in congenital adrenal hyperplasia

1987 • 174 citations

Tandem Duplication of D-Loop and Ribosomal RNA Sequences in Lizard Mitochondrial DNA

1986 • 172 citations

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

1988 • 170 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22

1988 • 157 citations

Molecular clock of silent substitution: At least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes

1982 • 154 citations

Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver.

1985 • 150 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

P ‐450 Cytochromes: Structure and Function

1987 • 145 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae

1988 • 132 citations

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

1987 • 112 citations

Identification and localization of amino acid substitutions between two phenobarbital-inducible rat hepatic microsomal cytochromes P-450 by micro sequence analyses.

1983 • 112 citations

Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat.

1985 • 104 citations

Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene.

1987 • 103 citations

Synthesis of cell wall components: Aspects of control

1988 • 103 citations

Induced Cytochrome P450 in Winter Flounder (Pseudopleuronectes americanus) from Coastal Massachusetts Evaluated by Catalytic Assay and Monoclonal Antibody Probes

1987 • 101 citations

cDNA cloning and functional expression in yeast Saccharomyces cerevisiae of β‐naphthoflavone‐induced rabbit liver P‐450 LM4 and LM6

1988 • 101 citations

The complete amino acid sequence of rabbit phenobarbital-induced liver microsomal cytochrome P-450.

1983 • 98 citations

Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form

1984 • 97 citations

Structure of a bovine gene for P-450c21 (steroid 21-hydroxylase) defines a novel cytochrome P-450 gene family.

1986 • 96 citations

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase

1988 • 95 citations

Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.

1985 • 86 citations

Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA.

1986 • 86 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.

1982 • 78 citations

The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450.

1985 • 78 citations

Potentiation and suppression of mouse liver cytochrome P‐450 isozymes during the acute‐phase response induced by bacterial endotoxin

1988 • 74 citations

Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes

1988 • 73 citations

Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1988 • 71 citations

Structural analysis of cloned cDNA for mRNA of microsomal cytochrome P-450(C21) which catalyzes steroid 21-hydroxylation in bovine adrenal cortex.

1986 • 70 citations

Genetically engineered V79 chinese hamster cell expression of purified cytochrome P‐450iib1 monooxygenase activity

1989 • 70 citations

Protein evolution and the molecular clock.

1976 • 69 citations

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.

1986 • 65 citations

Human P₃450: cDNA and complete amino acid sequence

1986 • 64 citations

Isolation of the gene for cytochrome P450 L1A1 (lanosterol 14α-demethylase) from Candida albicans

1988 • 58 citations

Molecular regulation of ethanol-inducible cytochrome P450-IIEI in hamsters

1988 • 57 citations

Temporal scaling of molecular evolution in primates and other mammals.

1986 • 56 citations

Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.

1985 • 55 citations

The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450.

1986 • 52 citations

Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450

1988 • 51 citations

Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM)

1987 • 48 citations

Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450

1988 • 48 citations

Complete amino acid sequence of a cytochrome P-450 isolated from beta-naphthoflavone-induced rabbit liver microsomes. Comparison with phenobarbital-induced and constitutive isozymes and identification of invariant residues.

1986 • 47 citations

Isolation of the alkane inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis

1987 • 46 citations

Isozyme specificity of testosterone 7α-hydroxylation in rat hepatic microsomes: Is cytochrome P-450a the sole catalyst?

1987 • 43 citations

Further characterization of RLM2 and comparison with a related form of cytochrome P-450, RLM2b

1988 • 36 citations

Chlorophenoxyacid herbicides induce microsomal cytochrome P-450 IVA1 (P-452) in rat liver

1988 • 32 citations

Cytochromes P-450

1988 • 32 citations

Induction of P-450 isoenzyme activities in Syrian golden hamster liver compared to rat liver as probed by the rate of 7-alkoxyresorufin-O-dealkylation

1988 • 26 citations

The major phenobarbital‐inducible cytochrome P‐450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19

1988 • 26 citations

The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2

1988 • 25 citations

Regulation of estrogen biosynthesis by human adipose cells in vitro

1987 • 25 citations

Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines

1988 • 23 citations

Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: Evidence that pyrazole-inducible P450Coh is distinct from acetone-lnducible P450ac

1988 • 21 citations

Purification of rat liver microsomal cytochrome P‐450b without the use of nonionic detergent

1988 • 17 citations

cDNA and complete amino acid sequence of mouse P₂450: allelic variant of mouse P₃450 gene

1986 • 17 citations

Constitutive and aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice

1988 • 15 citations

Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene

1988 • 14 citations

Characterization of rabbit cytochrome P450IIC4 cDNA and induction by phenobarbital of related hepatic mRNA levels

1987 • 14 citations

Effect of Antibodies against cytochrome P-450 on demethylation and denitrosation of N-nitrosodimethylamine and N-nitrosomethylaniline

1988 • 14 citations

Active site model of cytochrome P-450 LM2

1988 • 11 citations

ASSOCIATION ON TYPE I, TYPE II, AND REVERSE TYPE I DIFFERENCE SPECTRA WITH ABSOLUTE SPIN STATE OF CYTOCHROME P-450 IRON

1977 • 11 citations

Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation

1988 • 7 citations

Theophylline and antipyrine disposition in smoking and non‐smoking epileptic subjects.

1987 • 5 citations

Human drug metabolism polymorphisms: Use of recombinant DNA techniques

1987 • 4 citations