The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Peroxidase Isozymes from Horseradish Roots

1966 • 944 citations

Chloroperoxidase

1966 • 533 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Steady-state analysis of kinetic isotope effects in enzymic reactions

1975 • 376 citations

Isotope effects on enzyme-catalyzed reactions

1992 • 323 citations

Drug Metabolism: Chemical and Biochemical Aspects

1976 • 310 citations

The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation.

1982 • 182 citations

A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes

1979 • 163 citations

Studies of the ferric forms of cytochrome P-450 and chloroperoxidase by extended x-ray absotption fine structure. Characterization of the iron-nitrogen and iron-sulfur distances

1978 • 130 citations

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

1977 • 126 citations

Mechanism of N-demethylation of aminopyrine by hydrogen peroxide catalyzed by horseradish peroxidase, metmyoglobin, and protohemin

1978 • 126 citations

The P-450 Nature of the Carbon Monoxide Complex of Ferrous Chloroperoxidase

1973 • 121 citations

Improved Iodometric Method of Analysis for tert-Butyl Peresters

1958 • 93 citations

An electron paramagnetic resonance study of the high and low spin forms of chloroperoxidase.

1980 • 92 citations

Moessbauer investigations of chloroperoxidase and its halide complexes

1973 • 91 citations

Oxidations of Amines. III. Duality of Mechanism in the Reaction of Amines with Chlorine Dioxide

1967 • 89 citations

Selectivity of tertiary amine oxidations

1980 • 84 citations

The Reaction of Chlorite with Horseradish Peroxidase and Chloroperoxidase

1974 • 84 citations

Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine.

1980 • 83 citations

Magnetic circular dichroism studies. 44. Chloroperoxidase. Evidence for P-450 type heme environment from magnetic circular dichroism spectroscopy

1976 • 83 citations

Amine oxidation. Part IX. The electrochemical oxidation of some tertiary amines: the effect of structure on reactivity

1976 • 76 citations

Electron transfer from nitrogen in microsomal oxidation of amine and amide. Simulation of microsomal oxidation by anodic oxidation

1982 • 76 citations

Isotope effects in O- and N-demethylations mediated by rat liver microsomes: An application of direct insertion electron impact mass spectrometry

1974 • 73 citations

Moessbauer investigations of high-spin ferrous heme proteins. II. Chloroperoxidase, horseradish peroxidase, and hemoglobin

1975 • 72 citations

N-Demethylation reactions catalyzed by chloroperoxidase.

1980 • 71 citations

Characterization of the N-demethylation reactions catalyzed by horseradish peroxidase.

1983 • 67 citations

The Mechanisms of Permanganate Oxidation. VIII. Substituted Benzylamines¹

1966 • 66 citations

Radical mechanism of aminopyrine oxidation by cumene hydroperoxide catalyzed by purified liver microsomal cytochrome P-450

1980 • 61 citations

A novel P-450 model system for the N-dealkylation reaction

1981 • 57 citations

Mechanisms of EnzymaticS-Oxygenation of Thioanisole Derivatives andO-Demethylation of Anisole Derivatives Promoted by Both Microsomes and a Reconstituted System with Purified Cytochrome P-450

1982 • 55 citations

Hepatic microsomal N-dealkylation reaction. Molecular oxygen as the source of the oxygen atom

1969 • 52 citations

Amine oxidation. Part VII. The effect of structure on the reactivity of alkyl tertiary amines towards alkaline potassium hexacyanoferrate(III)

1973 • 39 citations

Isotope effects in enzymic N-demethylation of tertiary amines

1975 • 37 citations

Oxidations of amines. V. Duality of mechanism in the reactions of aliphatic amines with permanganate

1968 • 35 citations

Steady state kinetics of chloroperoxidase-catalyzed N-demethylation reactions.

1983 • 34 citations

Resonance Raman spectra of chloroperoxidase

1976 • 32 citations

Kinetics of the hydroperoxide-dependent dealkylation reactions catalyzed by rabbit liver microsomal cytochrome P-450.

1980 • 23 citations

Source of the oxygen atom in the product of cytochrome P-450-catalyzed N-demethylation reactions.

1983 • 22 citations

Source of oxygen in cytochrome P-450 catalyzed carbinolamine formation

1982 • 21 citations

Mechanism of N-demethylation of aminopyrine by catalase-organic hydroperoxide systems.

1980 • 3 citations

The effect of alkaline denaturation on organic hydroperoxide-supported N-demethylase activities of catalase.

1981 • 3 citations