4-Alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Cytochrome P-450

1986 • 734 citations

Hantzsch-type dihydropyridine hypotensive agents

1974 • 332 citations

The Hantzsch Reaction. I. Oxidative Dealkylation of Certain Dihydropyridines

1965 • 255 citations

Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms.

1982 • 221 citations

Homopolar‐ and Heteropolar Bond Dissociation Energies and Heats of Formation of Radicals and Ions in the Gas Phase. I. Data on organic molecules

1973 • 214 citations

The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation.

1982 • 182 citations

Exposure to Toxic Agents: The Heme Biosynthetic Pathway and Hemoproteins as Indicator

1985 • 134 citations

N-Alkylprotoporphyrin IX formation in 3,5-dicarbethoxy-1,4-dihydrocollidine-treated rats. Transfer of the alkyl group from the substrate to the porphyrin.

1981 • 106 citations

Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase

1979 • 99 citations

Selective inactivation of cytochrome P-450 isozymes by suicide substrates

1981 • 89 citations

Inhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effect

1980 • 75 citations

Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2, 6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts

1987 • 61 citations

Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes.

1987 • 58 citations

A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes

1983 • 52 citations

Effect of the suicide substrate 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine on the metabolism of xenobiotics and on cytochrome P-450 apoproteins.

1986 • 20 citations

Ueber die Einwirkung von Homologen des Acetaldehyds und Ammoniak auf Acetessigäther (resp. Benzoylessigäther)

1885 • 10 citations

Dihydropyridine Derivatives. I. The Reaction of 1,4-Diphenyl-3,5-diacetylpyridinium Salts with Inorganic Bases

1964 • 6 citations

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