The Topology of the Mammalian Cytochrome P-450 Active Site

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1982 • 422 citations

Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver.

1983 • 392 citations

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits

1974 • 304 citations

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver.

1982 • 275 citations

Reviews in biochemical toxicology

1979 • 274 citations

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1982 • 265 citations

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

1977 • 263 citations

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1969 • 227 citations

Cytochrome P-450 purified to apparent homogeneity from phenobarbital-induced rabbit liver microsomes: Catalytic activity and other properties

1974 • 164 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

Metabolism of benzo[a]pyrene

1975 • 148 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

Regioselectivity in the cytochromes P-450: Control by protein constraints and by chemical reactivities

1984 • 140 citations

The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes.

1983 • 138 citations

Properties of electrophoretically homogeneous constitutive forms of liver microsomal cytochrome P-450.

1981 • 121 citations

The complete amino acid sequence of rabbit phenobarbital-induced liver microsomal cytochrome P-450.

1983 • 98 citations

Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

1981 • 98 citations

Chiral sulfoxidations catalyzed by rat liver cytochromes P-450

1982 • 94 citations

Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes.

1981 • 91 citations

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin.

1984 • 90 citations

An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide.

1980 • 86 citations

Stereochemistry of cytochrome P-450-catalyzed epoxidation and prosthetic heme alkylation.

1983 • 79 citations

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P-448.

1984 • 76 citations

Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin.

1980 • 72 citations

A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase

1972 • 66 citations

Influence of Hydrophobic Character on the Relative Rate of Oxidation of Drugs by Rat Liver Microsomes

1971 • 62 citations

Domethylation Studies--I., The Effect of Chemical Structure and Lipis Solubility

1961 • 62 citations

Cytochrome P-450 inactivation: structure of the prosthetic heme adduct with propyne

1981 • 57 citations

Involvement of a hydrophobic site in the inhibition of the microsomal p-hydroxylation of aniline by alcohols.

1973 • 53 citations

Absolute stereochemistry of the trans-dihydrodiols formed from benzo[a]anthracene by liver microsomes

1979 • 47 citations

Pathways of metabolism of amphetamine and related compounds

1978 • 42 citations

Chiral orientation of prosthetic heme in the cytochrome P-450 active site.

1983 • 41 citations

Stereoselectivity of rat liver cytochrome P-450c on formation of benzo[a]pyrene 4,5-oxide

1981 • 40 citations

Stereoselective formation of benz[a]anthracene (+)-(5S,6R)-oxide and (+)-(8R,9S)-oxide by a highly purified and reconstituted system containing cytochrome P-450c

1982 • 35 citations

Absolute configuration of the trans-9,10-dihydrodiol metabolite of the carcinogen benzo[a]pyrene

1982 • 34 citations

The role of ionization in the N-demethylation of some N,N-dimethylamines.

1974 • 29 citations

The interaction of hepatic cytochrome P-450 with organic solvents. The effect of organic solvents on apparent spectral binding constants for hydrocarbon substrates.

1981 • 26 citations

A partition model for hepatic cytochrome p-450-hydrocarbon complex formation

1974 • 19 citations

Nuclear magnetic resonance studies of substrate-hemoprotein complexes in solution. I. The interaction of xylidine with myoglobin, hemoglobin, and cytochrome P450.

1977 • 19 citations

Regio- and Stereoselectivity of Hepatic Cytochrome P-450 Toward Polycyclic Aromatic Hydrocarbon Substrates

1982 • 14 citations

Interaction of Polycyclic Hydrocarbons with Cytochrome P-450. III. Effects of Hydrocarbon Binding on the Interaction of Some Ligands with P-4481 Heme1

1982 • 14 citations

(+)- and (–)-Benzo[a]pyrene 7,8-oxide : synthesis, absolute stereochemistry, and stereochemical correlation with other mammalian metabolites of benzo[a]pyrene

1980 • 14 citations

1H Fourier transform nuclear magnetic resonance relaxation rate studies on the interaction of acetanilide with purified isozymes of rabbit liver microsomal cytochrome P-450 and with cytochrome b5.

1982 • 12 citations

Biochemical Studies on Chemical Carcinogenesis: Role of Multiple Forms of Liver Microsomal Cytochrome P-450 in the Metabolism of Benzo[a]pyrene and Other Foreign Compounds

1978 • 9 citations

The mechanism of the cytochrome P-448 mediated 6-hydroxylation of 7-ethoxycoumarin

1984 • 6 citations

RESOLUTION OF MULTIPLE EQUILIBRIA IN BINDING OF SMALL MOLECULES TO CYTOCHROME P-450LM

1980 • 4 citations

Cited By (0)

No citing papers found in database