Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Chemical Carcinogenesis

1975 • 741 citations

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

1976 • 483 citations

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1979 • 375 citations

A microsome-dependent binding of benzo[a]pyrene to DNA.

1969 • 332 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Preparation and purification of lipid hydroperoxides from arachidonic and γ‐linolenic acids

1976 • 216 citations

Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.

1975 • 209 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

1976 • 188 citations

Studies on the formation of protein-bound derivatives of 3,4-benzpyrene in the epidermal fraction of mouse skin.

1951 • 165 citations

On the haemoprotein character of prostaglandin endoperoxide synthetase

1979 • 118 citations

Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-benzo(a)pyrene to mutagenic derivatives

1978 • 117 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

Metabolism of benzo (a) pyrene to reactive intermediate (S) via prostaglandin biosynthesis

1978 • 87 citations

Stereoelectronic factors in the solvolysis of bay region diol epoxides of polycyclic aromatic hydrocarbons

1978 • 74 citations

The distribution of radioactivity in mice following administration of 3,4-benzpyrene-5-C14 and 1,2,5,6-dibenzanthracene-9,10-C14.

1951 • 57 citations

Stimulation of prostaglandin biosynthesis by lipoic acid

1977 • 37 citations

Hydrolysis of syn- and anti-benzo[a]pyrene diol epoxides: stereochemistry, kinetics, and the effect of an intramolecular hydrogen bond on the rate of syn-diol epoxide solvolysis

1976 • 32 citations