Flavin coenzymes: at the crossroads of biological redox chemistry

Suicide enzyme inactivators

1976 • 366 citations

Proposed structure for coenzyme F₄₂₀ from methanobacterium

1978 • 346 citations

フラビン補酵素 生物学的酸化-還元化学の交差点

1980 • 255 citations

Studies on the Mechanism of Action of d-Amino Acid Oxidase

1971 • 208 citations

Spectral Properties of an Oxygenated Luciferase—Flavin Intermediate Isolated by Low-Temperature Chromatography

1973 • 194 citations

Synthetic approaches to the active sites of iron-sulfur proteins

1977 • 171 citations

Isolation of chick renal mitochondrial ferredoxin active in the 25-hydroxyvitamin D3-1alpha-hydroxylase system.

1976 • 156 citations

Direct Evidence for Carbanions and Covalent N5-Flavin-Carbanion Adducts as Catalytic Intermediates in the Oxidation of Nitroethane by d-Amino Acid Oxidase

1973 • 151 citations

Characterization of a cytochrome P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea

1976 • 144 citations

Simple synthesis of a 4a-hydroperoxy adduct of a 1,5-dihydroflavine: preliminary studies of a model for bacterial luciferase.

1976 • 143 citations

Chemical and enzymic properties of riboflavin analogs

1978 • 143 citations

A biochemical approach to some problems of environmental pollution.

1975 • 137 citations

Flavin and 5‐deazaflavin: A chemical evaluation of ‘modified’ flavoproteins with respect to the mechanisms of redox biocatalysis

1977 • 133 citations

The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions

1977 • 130 citations

The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase

1976 • 119 citations

8-Mercaptoflavins as active site probes of flavoenzymes.

1979 • 99 citations

Identification and Properties of New Flavins in Electron-Transferring Flavoprotein from Peptostreptococcus elsdenii and Pig-Liver Glycolate Oxidase

1974 • 95 citations

Synthesis of 10‐deazariboflavin and related 2,4‐Dioxopyrimido[4,5‐b]quinolines

1970 • 89 citations

ROSEOFLAVIN, A NEW ANTIMICROBIAL PIGMENT FROM STREPTOMYCES

1974 • 89 citations

Studies on the Mechanism of Action of the Flavoenzyme Lactate Oxidase

1973 • 88 citations

Studies on the Elimination Reaction of d-Amino Acid Oxidase with α-Amino-β-chlorobutyrate

1973 • 79 citations

Oxidation of thiophenol and nitroalkanes by an electron deficient isoalloxazine

1975 • 77 citations

Properties of flavins where the 8-methyl group is replaced by mercapto- residues.

1979 • 76 citations

Purification of intact old yellow enzyme using an affinity matrix for the sole chromatographic step.

1976 • 69 citations

Use of 5-deazaFAD to study hydrogen transfer in the D-amino acid oxidase reaction.

1975 • 69 citations

Identification and Properties of 8-Hydroxyflavin -Adenine Dinucleotide in Electron-Transferring Flavoprotein from Peptostreptococcus elsdenii

1976 • 68 citations

Chemiluminescent reactions and electrophilic oxygen donating ability of 4a-hydroperoxyflavins: general synthetic method for the preparation of N5-alkyl-1,5-dihydroflavins.

1977 • 67 citations

Spectral evidence for a flavin adduct in a monoalkylated derivative of pig heart lipoamide dehydrogenase.

1976 • 65 citations

Mechanism of the reaction of dithiols with flavins

1975 • 62 citations

Synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin and confirmation of its identity with the deazaisoalloxazine chromophore of Methanobacterium redox coenzyme F420

1979 • 62 citations

4a-Hydroperoxyflavin N-oxidation of tertiary amines

1979 • 60 citations

[45] Suicide substrates for flavoprotein enzymes

1978 • 59 citations

The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate

1976 • 57 citations

Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate]2-hydroxy-3-butynoate

1976 • 56 citations

8α-Substituted flavins of biological importance

1974 • 54 citations

One- and two-electron redox chemistry of 1-carba-1-deazariboflavin

1977 • 53 citations

Oxygen reactivity of p-hydroxybenzoate hydroxylase containing 1-deaza-FAD.

1980 • 53 citations

The reaction of phenylhydrazine with trimethylamine dehydrogenase and with free flavins.

1979 • 51 citations

Mechanistic studies on the rat kidney flavoenzyme L-α-hydroxy acid oxidase

1975 • 50 citations

Enzymic reduction of 5-deazariboflavine from reduced nicotinamide adenine dinucleotide by direct hydrogen transfer

1974 • 49 citations

A novel type of covalently bound coenzyme in trimethylamine dehydrogenase.

1978 • 48 citations

Stereospecificity of Hydrogen Transfer Reactions of the Pseudomonas aeruginosa Pyridine Nucleotide Transhydrogenase

1970 • 43 citations

Structure of the flavin adduct formed in the suicide reaction of .alpha.-hydroxybutynoate with D-lactate dehydrogenase

1979 • 30 citations

Demonstration of enzymic hydrogen transfer from substrate to a flavine

1974 • 29 citations

Reconstitution of flavin enzymes with 1-carba-1-deazaflavin coenzyme analogs

1977 • 28 citations

The stereospecificity of bacterial external flavoprotein monooxygenases for nicotinamide adenine dinucleotide

1977 • 27 citations

Deaza isosteres of riboflavine and lumichrome

1977 • 24 citations

The stereochemistry of NADH utilization by the flavoenzyme monooxygenase orcinol hydroxylase.

1979 • 20 citations

Metabolism and enzymology of fluorosuccinic acids

1970 • 19 citations

Deazaflavins as Cofactors for Flavocytochrome b₂ from Baker's Yeast

1979 • 16 citations

Oxidation of 9-hydroxy- and 9-methoxyfluorene carbanions by flavin. Proof of radical mechanism

1977 • 15 citations

Reactivation of lysozyme from inactive HNB-lysozyme

1975 • 8 citations