Chapter 27. Enzyme Changes Linked to Anticancer Drug Resistance

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Metaphase chromosome structure

1986 • 538 citations

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

1985 • 501 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Mechanistic Aspects of DNA Topoisomerases

1986 • 260 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia.

1984 • 236 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.

1984 • 222 citations

DNA topoisomerases from rat liver: physiological variations

1983 • 206 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Glutathione S-transferases and carcinogenesis

1987 • 170 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

1985 • 168 citations

Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei

1983 • 165 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases

1986 • 159 citations

Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.

1985 • 156 citations

Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.

1987 • 155 citations

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

1980 • 151 citations

Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

1987 • 150 citations

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.

1987 • 147 citations

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.

1987 • 141 citations

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells.

1985 • 136 citations

Patterns of Resistance and Therapeutic Synergism among Alkylating Agents1

2015 • 133 citations

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

1985 • 127 citations

Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesions.

1987 • 127 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

1987 • 113 citations

A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro

1986 • 104 citations

A simplified assay for O⁶-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

1984 • 104 citations

Effects of Modifying Structure on Electrophilic Reactions with Biological Nucleophiles

1984 • 103 citations

Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.

1987 • 94 citations

Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin.

1987 • 93 citations

Effects of in vitro purging with 4-hydroperoxycyclophosphamide on the hematopoietic and microenvironmental elements of human bone marrow

1985 • 87 citations

Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines.

1985 • 84 citations

Histochemical localization of aldehyde dehydrogenase in the respiratory tract of the Fischer-344 rat

1986 • 82 citations

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone

1983 • 79 citations

Resistance to adriamycin: relationship of cytotoxicity to drug uptake and DNA single- and double-strand breakage in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1986 • 77 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

Purification and Properties of Prostaglandin H‐E Isomerase from the Cytosol of Human Brain: Identification as Anionic Forms of Glutathione S‐Transferase

1987 • 72 citations

Deoxyribonucleic acid crosslinking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells

1984 • 72 citations

Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.

1983 • 68 citations

II. Isozyme specificity of rat liver glutathione S-transferases in the formation of PGF2α and PGE2 from PGH2

1987 • 66 citations

Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas.

1987 • 64 citations

Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines

1985 • 63 citations

On the multiplicity of rat liver glutathione S-transferases.

1985 • 60 citations

Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice

1987 • 58 citations

Effects of DNA gyrase inhibitors in Escherichia coli topoisomerase I mutants

1986 • 58 citations

Radiation inactivation of microsomal glutathione S-transferase.

1986 • 57 citations

Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.

1987 • 54 citations

Bone marrow transplantation in leukemia: Current status

1984 • 53 citations

Differential inhibition of rat and human glutathione S-transferase isoenzymes by plant phenols

1986 • 52 citations

Conversion of melphalan to 4-(glutathionyl)phenylalanine. A novel mechanism for conjugation by glutathione-S-transferases.

1987 • 49 citations

Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.

1986 • 46 citations

Enhancement of anti-cancer activity of cytotoxic chemotherapy with protection of normal tissues by inhibition of P.G. synthesis

1978 • 43 citations

Enzymatic transformation of PGH2 to PGF2α catalyzed by glutathione S-transferases

1987 • 43 citations

Antitumor Drug Resistance

1984 • 41 citations

Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards.

1986 • 39 citations

Glutathione and glutathione transferase levels in mouse granulocytes following cyclophosphamide administration.

1986 • 39 citations

The production of topoisomerase II-mediated DNA cleavage in human leukemia cells predicts their susceptibility to 4′-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA)

1986 • 39 citations

Glutathione S-transferases in human prostate

1987 • 37 citations

Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase

1987 • 30 citations

Occurrence of cytosolic protein and phosphoprotein changes in human colon tumor cells with the development of resistance to mitomycin C.

1985 • 29 citations

Effects on man of daily ingestion of small doses of isopropyl alcohol*1

1969 • 29 citations

Evidence that O6-alkylguanine-DNA alkyltransferase becomes covalently bound to DNA containing 1,3-bis(2-chloroethyl)-1-nitrosourea-induced precursors of interstrand cross-links

1987 • 28 citations

Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype.

1986 • 26 citations

A Dose-Response Study of Resistance of Leukemia L1210 to Cyclophosphamide2

1973 • 25 citations

Detection and partial characterization of a variant form of cytosolic aldehyde dehydrogenase isozyme

1986 • 24 citations

Improved anticancer effect by combining cytotoxic drugs with an inhibitor of prostaglandin synthesis

1979 • 23 citations

Changes in aldehyde dehydrogenase activity during diethylnitrosamine-initiated rat hepatocarcinogenesis

1987 • 22 citations

Changes in the pattern of aldehyde dehydrogenase activity in primary and metastatic adenocarcinomas of the human colon

1987 • 22 citations

Inhibition of human cationic glutathione S -transferase by nonsubstrate ligands

1987 • 21 citations

DNA damage and differential cytotoxicity produced in human cells by 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947), a new DNA-chloroethylating agent.

1985 • 19 citations

Purification of Human Liver Aldehyde Dehydrogenase by High‐Performance Liquid Chromatography and Identification of Isoenzymes by Immunoblotting

1987 • 13 citations

Stereochemical aspects of the glutathione S-transferase-catalyzed conjugations of alkyl halides.

1987 • 12 citations

Role of aldehyde dehydrogenase activity in cyclophosphamide metabolism in rat hepatoma cell lines

1987 • 9 citations

Synthesis of reactive metabolite-analogues of cyclophosphamide for comparisons of NMR kinetic parameters and anticancer screening data.

1986 • 7 citations

A comparison of topoisomerase I activity in normal and transformed cells

1986 • 4 citations

Marcel Proust

1976 • 1 citations

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