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(E)-4-Hydroxy-2-Nonenal May be Involved in the Pathogenesis of Parkinson’s Disease

1998 • 202 citations

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

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IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal

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4-Hydroxynonenal Induces Adaptive Response and Enhances PC12 Cell Tolerance Primarily through Induction of Thioredoxin Reductase 1 via Activation of Nrf2

2005 • 189 citations

Environmental Stress Causes Oxidative Damage to Plant Mitochondria Leading to Inhibition of Glycine Decarboxylase

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The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin

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Oxidatively modified autoantigens in autoimmune diseases

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Trans -4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis

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Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease

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Induction of Redox Instability of Bovine Myoglobin by Adduction with 4-Hydroxy-2-nonenal

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Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

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Inhibition of Thioredoxin and Thioredoxin Reductase by 4-Hydroxy-2-nonenal in Vitro and in Vivo

2006 • 163 citations

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4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis

1999 • 162 citations

Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?

2002 • 162 citations

Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats

2003 • 162 citations

Persistent oxidative stress in human colorectal carcinoma, but not in adenoma

1999 • 159 citations

A Lipid Peroxidation-derived Inflammatory Mediator

2004 • 156 citations

Role of Mitogen-activated Protein Kinases in 4-Hydroxy-2-nonenal-induced Actin Remodeling and Barrier Function in Endothelial Cells

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2000 • 155 citations

Monoclonal Antibodies for Detection of 4-Hydroxynonenal Modified Proteins

1996 • 152 citations

Activation and Function of Mitochondrial Uncoupling Protein in Plants

2004 • 152 citations

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

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Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse

2003 • 151 citations

Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis

2005 • 150 citations

Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

1998 • 149 citations

4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition

1999 • 149 citations

Covalent Modification of Epithelial Fatty Acid-binding Protein by 4-Hydroxynonenal in Vitro and in Vivo

2002 • 145 citations

Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells

2000 • 145 citations

The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3

2005 • 145 citations

Cysteine Modification by Lipid Peroxidation Products Inhibits Protein Disulfide Isomerase

2005 • 144 citations

Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells

1997 • 144 citations

Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart

1999 • 143 citations

Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease

2002 • 141 citations

Activation of EGF receptor by oxidized LDL

1998 • 141 citations

Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal

2003 • 140 citations

Modification of Cytochrome c by 4-hydroxy- 2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adducts

2004 • 140 citations

Mercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in the Rat

1995 • 139 citations

Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation

2004 • 139 citations

Characterization of Epitopes Recognized by 4-Hydroxy-2-nonenal Specific Antibodies

1995 • 138 citations

Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways

2003 • 138 citations

Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression

2003 • 137 citations

Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

2005 • 137 citations

4-Hydroxynonenal and Malondialdehyde Hepatic Protein Adducts in Rats Treated with Carbon Tetrachloride: Immunochemical Detection and Lobular Localization

1999 • 136 citations

Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidation-derived Aldehyde 4-Hydroxy-trans-2-nonenal (HNE)

2006 • 134 citations

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gα_q/11

1997 • 134 citations

Analytical methods for trace levels of reactive carbonyl compounds formed in lipid peroxidation systems

2006 • 133 citations

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

1998 • 133 citations

Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling

2003 • 129 citations

Oxidative DNA Damage and Cardiovascular Disease

2001 • 128 citations

The oxidation of α-β unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases

1987 • 128 citations

Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product

1997 • 125 citations

Interactions of α, β-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1

1997 • 125 citations

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

2004 • 124 citations

Cardiac Mitochondrial NADP+-isocitrate Dehydrogenase Is Inactivated through 4-Hydroxynonenal Adduct Formation

2003 • 124 citations

Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress

2003 • 122 citations

Alterations in Gene Expression Induced by the Lipid Peroxidation Product, 4-Hydroxy-2-nonenal

2005 • 121 citations

4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells

2003 • 120 citations

Oxidized LDL-Induced Smooth Muscle Cell Proliferation Involves the EGF Receptor/PI-3 Kinase/Akt and the Sphingolipid Signaling Pathways

2002 • 120 citations

Malarial pigment (haemozoin) : a very active 'inert' substance

1997 • 119 citations

Catalytic site‐specific inhibition of the 20S proteasome by 4‐hydroxynonenal

2004 • 118 citations

Molecular Basis of Enzyme Inactivation by an Endogenous Electrophile 4-Hydroxy-2-nonenal: Identification of Modification Sites in Glyceraldehyde-3-phosphate Dehydrogenase

2003 • 118 citations

Lipid peroxidation in rat brain is increased by simulated weightlessness and decreased by a soy-protein diet.

2002 • 117 citations

Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome

1996 • 115 citations

4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

2002 • 115 citations

4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine

1995 • 114 citations

Oxidative stress and HNE conjugation of GLUT3 are increased in the hippocampus of diabetic rats subjected to stress

2000 • 114 citations

Mass spectrometric characterization of covalent modification of human serum albumin by 4‐hydroxy‐trans‐2‐nonenal

2006 • 112 citations

Aldose Reductase Regulates Growth Factor-Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Colon Cancer Cells

2006 • 112 citations

Inhibition of Hsp72-Mediated Protein Refolding by 4-Hydroxy-2-nonenal

2004 • 112 citations

Ubiquitin‐dependent lysosomal degradation of the HNE‐modified proteins in lens epithelial cells

2004 • 111 citations

Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition

2005 • 110 citations

Covalent modifications of aminophospholipids by 4-hydroxynonenal

1998 • 110 citations

Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses

2003 • 108 citations

Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis

1994 • 108 citations

Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: A single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls

2005 • 108 citations

The Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells

1999 • 107 citations

Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease

2004 • 106 citations

Several Closely Related Glutathione S-Transferase Isozymes Catalyzing Conjugation of 4-Hydroxynonenal Are Differentially Expressed in Human Tissues

1994 • 105 citations

Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading

2005 • 104 citations

Endotoxin-Induced Cardiomyopathy and Systemic Inflammation in Mice Is Prevented by Aldose Reductase Inhibition

2006 • 102 citations

Increased Levels of Lipid Peroxidation Products Malondialdehyde and 4-Hydroxynonenal after Perinatal Hypoxia

1996 • 102 citations

HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells

2005 • 102 citations

Mass Spectroscopic Characterization of Protein Modification by 4-Hydroxy-2-(E)-nonenal and 4-Oxo-2-(E)-nonenal

2003 • 102 citations

Targeting of the c-Abl Tyrosine Kinase to Mitochondria in the Necrotic Cell Death Response to Oxidative Stress

2001 • 101 citations

Serum 4-Hydroxy-2-Nonenal-Modified Albumin Is Elevated in Patients with Type 2 Diabetes Mellitus

2000 • 100 citations

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

1999 • 99 citations

Increased circulating products of lipid peroxidation in patients with alcoholic liver disease.

1998 • 98 citations

Increased Etheno-DNA Adducts in Affected Tissues of Patients Suffering from Crohn’s Disease, Ulcerative Colitis, and Chronic Pancreatitis

2006 • 98 citations

Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E.

1999 • 98 citations

4-Hydroxynonenal and Cell Signalling

1998 • 96 citations

γ-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal

1998 • 95 citations

4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression

2000 • 95 citations

Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells

2002 • 94 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal

2003 • 93 citations

Susceptibility of Amyloid β Peptide Degrading Enzymes to Oxidative Damage: A Potential Alzheimer's Disease Spiral

2005 • 93 citations

Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages.

1994 • 93 citations

Proteasomal dysfunction induced by 4‐hydroxy‐2,3‐trans‐nonenal, an end‐product of lipid peroxidation: a mechanism contributing to neurodegeneration?

2002 • 92 citations

Mutational Spectrum and Genotoxicity of the Major Lipid Peroxidation Product, trans-4-Hydroxy-2-nonenal, Induced DNA Adducts in Nucleotide Excision Repair-Proficient and -Deficient Human Cells

2003 • 92 citations

Predominance of the 1,N2-propano 2′-deoxyguanosine adduct among 4-hydroxy-2-nonenal-induced DNA lesions

2004 • 91 citations

Increased Circulating Products of Lipid Peroxidation in Patients with Alcoholic Liver Disease

1998 • 89 citations

Determination of the lipid peroxidation product trans-4-hydroxy-2-nonenal in biological samples by high-performance liquid chromatography and combined capillary column gas chromatography—negative-ion chemical ionisation mass spectrometry

1989 • 89 citations

Identification of Bovine Heart Cytochrome c Oxidase Subunits Modified by the Lipid Peroxidation Product 4-Hydroxy-2-nonenal^,

2002 • 88 citations

Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway

2007 • 88 citations

Immunochemical Evidence Supporting 2-Pentylpyrrole Formation on Proteins Exposed to 4-Hydroxy-2-nonenal

1996 • 87 citations

Pyridoxamine: An Extremely Potent Scavenger of 1,4-Dicarbonyls

2004 • 87 citations

Cloning and heterologous expression of cDNA encoding class Alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds

1992 • 86 citations

4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes

2006 • 85 citations

Phospholipid Hydroxyalkenals

2003 • 85 citations

Study of protein modification by 4-hydroxy-2-nonenal and other short chain aldehydes analyzed by electrospray ionization tandem mass spectrometry

2003 • 84 citations

4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium

1995 • 84 citations

A 1-Hour Enzyme-Linked Immunosorbent Assay for Quantitation of Acrolein- and Hydroxynonenal-Modified Proteins by Epitope-Bound Casein Matrix Method

1999 • 83 citations

4-Hydroxynonenal induces apoptosis, NF-κB-activation and formation of 8-isoprostane in vascular smooth nmuscle cells

2001 • 82 citations

Calorie restriction delays lipid oxidative damage in Drosophila melanogaster

2005 • 81 citations

Retinal proteins modified by 4-hydroxynonenal: Identification of molecular targets

2006 • 81 citations

Insulin neuroprotection against oxidative stress in cortical neurons—Involvement of uric acid and glutathione antioxidant defenses

2005 • 81 citations

Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4‐hydroxynonenal to cartilage degradation

2005 • 80 citations

Covalent modification of actin by 4‐hydroxy‐trans‐2‐nonenal (HNE): LC‐ESI‐MS/MS evidence for Cys374 Michael adduction

2005 • 79 citations

Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury

1999 • 78 citations

Signal transduction of erythropoietin in endothelial cells

1996 • 78 citations

Cellular Response to the Redox Active Lipid Peroxidation Products: Induction of Glutathione S-Transferase P by 4-Hydroxy-2-nonenal

1997 • 77 citations

Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease

2006 • 77 citations

Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis

2004 • 77 citations

New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid

2006 • 76 citations

Increased levels of 4‐hydroxynonenal in human monocytes fed with malarial pigment hemozoin A possible clue for hemozoin toxicity

1996 • 74 citations

Relationship Between Oxidative Stress and Systolic Dysfunction in Patients With Hypertrophic Cardiomyopathy

2005 • 73 citations

Detoxification of cytotoxic α,β‐unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscle

2002 • 73 citations

Oxidative stress in chronic renal failure as a cardiovascular risk factor.

2002 • 73 citations

Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat precision-cut liver slices

2000 • 73 citations

Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells

2001 • 72 citations

4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease

2004 • 72 citations

Carnosine Inhibits (E)-4-Hydroxy-2-nonenal-Induced Protein Cross-Linking: Structural Characterization of Carnosine−HNE Adducts¹

2003 • 71 citations

Phorbol Ester-induced Generation of Reactive Oxygen Species Is Protein Kinase Cβ-dependent and Required for SAPK Activation

2000 • 71 citations

Suppression of apoptosis by calorie restriction in aged kidney

2004 • 70 citations

Comparison of the Inactivation of Microsomal Glucose-6-Phosphatase by in Situ Lipid Peroxidation-Derived 4-Hydroxynonenal and Exogenous 4-Hydroxynonenal

1986 • 70 citations

Cytotoxic and genotoxic effects of 4-hydroxynonenal in cerebral endothelial cells

1997 • 70 citations

The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal

2005 • 68 citations

Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity

2003 • 68 citations

4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway

2004 • 68 citations

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

2007 • 68 citations

Both Wheat (Triticum aestivum) Bran Arabinoxylans and Gut Flora-Mediated Fermentation Products Protect Human Colon Cells from Genotoxic Activities of 4-Hydroxynonenal and Hydrogen Peroxide

2006 • 68 citations

4‐Hydroxynonenal Immunoreactivity is Increased in Human Hippocampus After Global Ischemia

2001 • 67 citations

Desensitization of Platelet-Derived Growth Factor Receptor-β by Oxidized Lipids in Vascular Cells and Atherosclerotic Lesions

2006 • 66 citations

Adaptive response induced by lipid peroxidation products in cell cultures

2005 • 66 citations

Interaction between 4-Hydroxy-2,3-alkenals and the Platelet-derived Growth Factor-β Receptor

2000 • 65 citations

Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats

2001 • 65 citations

Regulation of constitutive neutrophil apoptosis by the α,β-unsaturated aldehydes acrolein and 4-hydroxynonenal

2005 • 64 citations

Quantitative Measurement of 4-Hydroxyalkenals in Oxidized Low-Density Lipoprotein by Gas Chromatography-Mass Spectrometry

1995 • 64 citations

Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.

1992 • 64 citations

Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction

2005 • 63 citations

High-Density Lipoproteins Prevent the Oxidized Low-Density Lipoprotein–Induced Endothelial Growth Factor Receptor Activation and Subsequent Matrix Metalloproteinase-2 Upregulation

2005 • 63 citations

Malarial pigment (haemozoin): a very active ‘inert’ substance

1997 • 63 citations

Identification of Intermediate Pathways of 4-Hydroxynonenal Metabolism in the Rat

2003 • 63 citations

Sensitivity of plant mitochondrial terminal oxidases to the lipid peroxidation product 4-hydroxy-2-nonenal (HNE)

2005 • 63 citations

Modifications of proteins by 4-hydroxy-2-nonenal in the ventilatory muscles of rats

2006 • 63 citations

Formation of 4–Hydroxynonenal Adducts With Cytochrome C Oxidase in Rats Following Short–Term Ethanol Intake

1999 • 62 citations

Studies on epitopes on low-density lipoprotein modified by 4-hydroxynonenal. Biochemical characterization and determination

1992 • 62 citations

Induction of Procollagen Type I Gene Expression and Synthesis in Human Hepatic Stellate Cells by 4-Hydroxy-2,3-Nonenal and Other 4-Hydroxy-2,3-Alkenals Is Related to Their Molecular Structure

1996 • 61 citations

Oxidative Stress and Cardiovascular Disease in Dialyzed Patients

2002 • 61 citations

4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line

2004 • 61 citations

4-Hydroxynonenal Induces Rat γ-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase–Mediated Electrophile Response Element/Nuclear Factor Erythroid 2–Related Factor 2 Signaling

2005 • 61 citations

Mildly Oxidized LDL Induces Activation of Platelet-Derived Growth Factor β-Receptor Pathway

2001 • 61 citations

Biogenic 4‐hydroxy‐2‐nonenal activates transcription factor AP‐1 but not NF‐κB in cells of the macrophage lineage

1997 • 61 citations

Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria

2006 • 60 citations

Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets

2005 • 60 citations

Enzyme-linked immunosorbent assay for 4-hydroxynonenal–histidine conjugates

2006 • 60 citations

Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers

1999 • 60 citations

Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal

2003 • 59 citations

Reactive Lipid Species from Cyclooxygenase-2 Inactivate Tumor Suppressor LKB1/STK11

2005 • 59 citations

High sensitivity of plasma membrane ion transport ATPases from human neutrophils towards 4-hydroxy-2,3-trans-nonenal

2003 • 58 citations

Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone

1998 • 58 citations

Simvastatin prevents oxygen and glucose deprivation/reoxygenation‐induced death of cortical neurons by reducing the production and toxicity of 4‐hydroxy‐2E‐nonenal

2006 • 57 citations

Long-chain adducts of trans-4-hydroxy-2-nonenal to DNA bases cause recombination, base substitutions and frameshift mutations in M13 phage☆

2004 • 57 citations

Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney

1997 • 55 citations

Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal

2001 • 55 citations

Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containingn-3 andn-6 polyunsaturated fatty acids

2005 • 55 citations

Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells

1996 • 55 citations

γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells

2005 • 54 citations

Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal.

2006 • 54 citations

Differential regulation of cyclooxygenase‐2 and inducible nitric oxide synthase by 4‐hydroxynonenal in human osteoarthritic chondrocytes through ATF‐2/CREB‐1 transactivation and concomitant inhibition of NF‐κB signaling cascade

2006 • 54 citations

4-Hydroxy-2-nonenal Increases γ -Glutamylcysteine Synthetase Gene Expression in Alveolar Epithelial Cells

2001 • 53 citations

c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-β1 and 4-hydroxynonenal in colon mucosa

2006 • 53 citations

Glutathione Conjugation of 4-Hydroxy-trans-2,3-nonenal in the Rat in Vivo, the Isolated Perfused Liver and Erythrocytes

1999 • 53 citations

Regulation of CD95 (Fas) Expression and Fas-Mediated Apoptotic Signaling in HLE B-3 Cells by 4-Hydroxynonenal

2006 • 53 citations

Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-Terminal protein kinase pathway

2001 • 53 citations

Identification of metabolic pathways of the lipid peroxidation product 4‐hydroxynonenal by mitochondria isolated from rat kidney cortex

1994 • 52 citations

Lipid peroxidation in human diseases: Evidence of red cell oxidative stress after circulatory shock

1989 • 52 citations

Interaction with phospholipids modulates α-synuclein nitration and lipid–protein adduct formation

2005 • 51 citations

4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase

2004 • 51 citations

Identification of 4-Hydroxy-2-nonenal-Modified Peptides within Unfractionated Digests Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

2004 • 51 citations

Immunoaffinity Purification and Characterization of 4-Hydroxy-2-nonenal- and Malondialdehyde-Modified Peptides by Electrospray Ionization Tandem Mass Spectrometry

2002 • 51 citations

Astrocytes Accumulate 4-Hydroxynonenal Adducts in Murine Scrapie and Human Creutzfeldt–Jakob Disease

2002 • 51 citations

Role of p38 Mitogen-Activated Protein Kinase in the 4-Hydroxy-2-Nonenal-Induced Cyclooxygenase-2 Expression

2002 • 51 citations

Immunohistochemical Detection of 4-Hydroxy-2-nonenal-Modified-Protein Adducts in Human Alcoholic Liver Diseases

1998 • 50 citations

Oxidative stress in chronic lymphoedema

2002 • 50 citations

Plasma lipoperoxidative markers in ischaemic stroke suggest brain embolism.

1997 • 50 citations

Aldehyde reductase gene expression by lipid peroxidation end products, MDA and HNE

2000 • 49 citations

Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation

2005 • 49 citations

N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death

2006 • 49 citations

Independent Synthesis, Solution Behavior, and Studies on the Mechanism of Formation of a Primary Amine-Derived Fluorophore Representing Cross-linking of Proteins by (E)-4-Hydroxy-2-nonenal

1999 • 48 citations

Resveratrol Protects Against 4-Hydroxynonenal-Induced Apoptosis by Blocking JNK and c-JUN/AP-1 Signaling

2005 • 48 citations

Site‐specific mutagenicity of stereochemically defined 1,N²‐deoxyguanosine adducts of trans‐4‐hydroxynonenal in mammalian cells

2003 • 48 citations

Quinones Facilitate the Self-Assembly of the Phosphorylated Tubulin Binding Region of Tau into Fibrillar Polymers

2004 • 48 citations

Determination of the lipid peroxidation product (E)-4-hydroxy-2-nonenal in clinical samples by gas chromatography-negative-ion chemical ionisation mass spectrometry of the O-pnetafluorobenzyl oxime

1997 • 48 citations

Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal

2002 • 48 citations

Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation

2003 • 47 citations

Vascular smooth muscle cell activation and growth by 4-hydroxynonenal

2001 • 47 citations

Activation of PKC-β isoforms mediates HNE-induced MCP-1 release by macrophages

2002 • 47 citations

Circulating 4-hydroxynonenal–protein thioether adducts assessed by gas chromatography–mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats

2006 • 46 citations

Oxidative Damage and Transforming Growth Factor β1 Expression in Pretumoral and Tumoral Lesions of Human Intestine

1997 • 46 citations

Pathological significance of oxidative cellular damage in human alcoholic liver disease

2003 • 46 citations

Effect of Glutathione Augmentation on Lipid Peroxidation after Spinal Cord Injury

2002 • 45 citations

Urinalysis of 4-hydroxynonenal, a marker of oxidative stress, using stir bar sorptive extraction–thermal desorption–gas chromatography/mass spectrometry

2006 • 45 citations

4-Hydroxynonenal Decreases Interleukin-6 Expression and Protein Production in Primary Rat Kupffer Cells by Inhibiting Nuclear Factor-κB Activation

2002 • 45 citations

Susceptibility of actin to modification by 4-hydroxy-2-nonenal

2005 • 45 citations

Measurement of 4-hydroxynonenal in small volume blood plasma samples: modification of a gas chromatographic–mass spectrometric method for clinical settings

2002 • 44 citations

Protective effect of S-allyl-l-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells

2003 • 44 citations

The effect of high-density lipoproteins on the formation of lipid/protein conjugates during in vitro oxidation of low-density lipoprotein

2003 • 44 citations

Regulation of glycogen synthase kinase‐3β by products of lipid peroxidation in human neuroblastoma cells

2004 • 43 citations

1,4-Dihydroxynonene Mercapturic Acid, the Major End Metabolite of Exogenous 4-Hydroxy-2-nonenal, Is a Physiological Component of Rat and Human Urine

1998 • 43 citations

Inhibition of aldehyde detoxification in CNS mitochondria by fungicides

2006 • 43 citations

Aging and oxidative stress in progressive supranuclear palsy

2006 • 42 citations

The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (−/−) mice

2005 • 42 citations

Aldehydes from n-6 fatty acid peroxidation. Effects on aminophospholipids

2002 • 42 citations

Enhanced lipid peroxidation in synoviocytes from patients with osteoarthritis.

2003 • 41 citations

Identification of Novel Urinary Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in Rats

1998 • 41 citations

4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines

2006 • 41 citations

Proteomic Analysis of Nitrated and 4-Hydroxy-2-Nonenal-Modified Serum Proteins During Aging

2006 • 41 citations

Solid Phase Extraction and Liquid Chromatography−Tandem Mass Spectrometry for the Evaluation of 4-Hydroxy-2-nonenal in Pork Products

2002 • 40 citations

Increased lipid peroxidation in children with autoimmune diseases

1997 • 39 citations

Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients.

1993 • 39 citations

Detoxification of reactive aldehydes in mitochondria: Effects of age and dietary restriction

1996 • 38 citations

4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways

2004 • 38 citations

4-Hydroxy-2-nonenal-Trapping ELISA: Direct Evidence for the Release of a Cytotoxic Aldehyde from Oxidized Low Density Lipoproteins

1995 • 38 citations

Blood 5‐hydroxytryptamine, 5‐hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury

2006 • 38 citations

Conditional Expression of 15-Lipoxygenase-1 Inhibits the Selenoenzyme Thioredoxin Reductase

2004 • 38 citations

The Role of Chemically Induced Glutathione and Glutathione S-Transferase in Protecting Against 4-Hydroxy-2-Nonenal- Mediated Cytotoxicity in Vascular Smooth Muscle Cells

2003 • 37 citations

JNK3 contributes to c‐jun induction and apoptosis in 4‐hydroxynonenal‐treated sympathetic neurons

2002 • 37 citations

4-Hydroxy-2-nonenal Is a Powerful Endogenous Inhibitor of Endothelial Response

2001 • 37 citations

Analysis in the Rat of 4-Hydroxynonenal Metabolites Excreted in Bile: Evidence of Enterohepatic Circulation of These Byproducts of Lipid Peroxidation

1999 • 36 citations

Origin of 4-hydroxynonenal incubation-induced inhibition of dopamine transporter and Na+/K+ adenosine triphosphate in rat striatal synaptosomes

1999 • 36 citations

4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells

2004 • 35 citations

Correction for Ho et al., Isolation of anti-CD22 Fv with high affinity by Fv display on human cells

2007 • 35 citations

Synthesis and Evaluation of Neuroprotective α,β-Unsaturated Aldehyde Scavenger Histidyl-Containing Analogues of Carnosine

2005 • 34 citations

Role of 4‐hydroxynonenal in the hemozoin‐mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM‐CSF/IL‐4

2005 • 34 citations

Determination of 4-hydroxy-2-nonenal at cellular levels by means of electrospray mass spectrometry

1999 • 34 citations

Reduction of 4-Hydroxynonenal and 4-Hydroxyhexenal by Retinal Aldose Reductase

1998 • 34 citations

Phenolic antioxidants trolox and caffeic acid modulate the oxidized LDL‐induced EGF‐receptor activation

2001 • 34 citations

Role of endogenous interleukin-10 production and lipid peroxidation in patients with acute myocardial infarction treated with primary percutaneous transluminal coronary angioplasty interleukin-10 and primary angioplasty

2004 • 34 citations

Vitamin C conjugates of genotoxic lipid peroxidation products: Structural characterization and detection in human plasma

2004 • 33 citations

Rapid increase in serum lipid peroxide 4-hydroxynonenal (HNE) through monocyte NADPH oxidase in early endo-toxemia

2005 • 33 citations

Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine.

1991 • 33 citations

(S)-Preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats

2001 • 33 citations

4-Hydroxy-2-Nonenal Enhances Fibronectin Production by IMR-90 Human Lung Fibroblasts Partly via Activation of Epidermal Growth Factor Receptor-Linked Extracellular Signal-Regulated Kinase p44/42 Pathway

2002 • 33 citations

Chlamydia pneumoniae activates IKK/IκB-mediated signaling, which is inhibited by 4-HNE and following primary exposure

2002 • 33 citations

c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-β 1 and 4-hydroxynonenal in colon mucosa

2006 • 33 citations

Analysis of Fe^II‐mediated decomposition of a linoleic acid‐derived lipid hydroperoxide by liquid chromatography/mass spectrometry

2005 • 33 citations

Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats

2004 • 32 citations

Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria

2005 • 32 citations

Mutagenic Effects of 4-Hydroxynonenal Triacetate, a Chemically Protected Form of the Lipid Peroxidation Product 4-Hydroxynonenal, as Assayed in L5178Y/Tk⁺/– Mouse Lymphoma Cells

2005 • 32 citations

Dihydroxynonene mercapturic acid, a urinary metabolite of 4‐hydroxynonenal, as a biomarker of lipid peroxidation

2005 • 31 citations

4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: The role of PKC-δ

2005 • 31 citations

Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor β in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal

2006 • 31 citations

Modulation of D1-like dopamine receptor function by aldehydic products of lipid peroxidation

2003 • 30 citations

High circulating levels of 7β- and 7α-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy

2005 • 30 citations

Accumulation of aldehydic lipid peroxidation products during postanoxic reoxygenation of isolated rat hepatocytes

1993 • 29 citations

Activation of phosphoinositide‐specific phospholipase C of rat neutrophils by the chemotactic aldehydes 4‐hydroxy‐2,3‐trans‐nonenal and 4‐hydroxy‐2,3‐trans‐octenal

1994 • 29 citations

4-Hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney

1995 • 29 citations

Bispecific Abs against modified protein and DNA with oxidized lipids

2006 • 28 citations

Measurement of Aldehydes in Low Density Lipoprotein by High Performance Liquid Chromatography

1997 • 27 citations

Characterisation of adducts of the lipid peroxidation product 4‐hydroxy‐2‐nonenal and amyloid β‐peptides by liquid chromatography/electrospray ionisation mass spectrometry

2002 • 27 citations

The Effect of CYP2E1-Dependent Oxidant Stress on Activity of Proteasomes in HepG2 Cells

2005 • 27 citations

A new method for detection of HNE-histidine conjugates in rat inflammatory cells

2005 • 27 citations

Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal

2005 • 26 citations

Formation of 4-Hydroxy-2-Nonenal Protein Adducts in the Ischemic Rat Heart After Transplantation

2005 • 26 citations

Effect of enzyme-resistant starch on formation of 1,N(2)-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal and cell proliferation in the colonic mucosa of healthy volunteers.

2002 • 26 citations

Metabolism of 4‐hydroxynonenal by the rat heptoma cell line MH₁C₁

1988 • 26 citations

Validation of Malondialdehyde and 4-Hydroxy-2-trans-Nonenal Measurement in Plasma by NICI-GC-MS

1998 • 25 citations

2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase

1998 • 24 citations

F₂‐Isoprostanes as biomarkers of lipid peroxidation in patients with chronic renal failure

2005 • 24 citations

Oxidative metabolism of 4-hydroxy-2,3-nonenal during diethyl-nitrosamine-induced carcinogenesis in rat liver

1989 • 24 citations

Intracellular Metabolism of 4-Hydroxynonenal in Primary Cultures of Rabbit Synovial Fibroblasts

1997 • 24 citations

Systemically circulating oxidative species in human deep venous thrombosis

1998 • 23 citations

Sensitivity of Protein Tyrosine Phosphatase Activity to the Redox Environment, Cytochrome c, and Microperoxidase

2005 • 23 citations

Elevated serum concentration of cardiotoxic lipid peroxidation products in chronic renal failure in relation to severity of renal anemia.

2002 • 23 citations

Daily weight gain and protein catabolic rate are lower over the long interdialytic interval

2003 • 22 citations

Postanoxic formation of aldehydic lipid peroxidation products in human renal tubular cells

1995 • 22 citations

Role of 4‐hydroxy‐2,3‐nonenal in the pathogenesis of fibrosis

2005 • 22 citations

Mass spectrometric analysis of 2′-deoxyribonucleoside and 2′-deoxyribonucleotide adducts with aldehydes derived from lipid peroxidation

1998 • 21 citations

Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells

2002 • 21 citations

4-Hydroxynonenal is Markedly Higher in Patients on a Standard Long-term Home Parenteral Nutrition

2003 • 21 citations

Lipid peroxidation in human proteinuric disease

2001 • 21 citations

Astrocytic Biotransformation oftrans-4-Hydroxy-2-nonenal Is Dose-Dependent

2006 • 20 citations

Hepatocellular Metabolism of 4-Hydroxy-2,3-Nonenal Is Impaired in Conditions of Chronic Cholestasis

1995 • 20 citations

PTEN, Akt, and GSK3β signalling in rat primary cortical neuronal cultures following tumor necrosis factor‐α and trans‐4‐hydroxy‐2‐nonenal treatments

2006 • 19 citations

4‐Hydroxynonenal contributes to NGF withdrawal‐induced neuronal apoptosis

2003 • 19 citations

Modulation of Voltage-Gated Ca2+ Current by 4-Hydroxynonenal in Dentate Granule Cells

2004 • 19 citations

Evidence of Preferential Protein Targets for Age‐Related Modifications in Peripheral Blood Lymphocytes

2004 • 18 citations

Simultaneous determination of 4-hydroxy-2-alkenals, lipid peroxidation toxic products

2003 • 18 citations

4-Hydroxynonenal disrupts zinc export in primary rat cortical cells

2005 • 18 citations

Down-modulation of nuclear localisation and pro-fibrogenic effect of 4-hydroxy-2,3-nonenal by thiol- and carbonyl-reagents

2002 • 17 citations

A strategy for distinguishing modified peptides based on post‐digestion ¹⁸O labeling and mass spectrometry

2005 • 17 citations

Evaluation of purine nucleotide loss, lipid peroxidation and ultrastructural alterations in post‐hypoxic hepatocytes.

1997 • 17 citations

Metabolic pathways of lipid peroxidation product 4-hydroxynonenal in hepatocytes - quantitative assessment of an antioxidative defense system

1990 • 17 citations

Aldehydic products of lipid peroxidation inactivate cytochrome P-450

1999 • 16 citations

Formation and Metabolism of the Lipid Peroxidation Product 4-Hydroxynonenal in Liver and Small Intestine

1993 • 16 citations

Improvement of lipase stability in the presence of commercial triglycerides

2003 • 16 citations

Determination of 4-hydroxy-2-nonenal in primary rat hepatocyte cultures by liquid chromatography with laser induced fluorescence detection

1999 • 16 citations

Method for analysis of 4‐hydroxy‐2‐(E)‐nonenal with solid‐phase microextraction

2002 • 15 citations

Toxic aldehydes formed by lipid peroxidation I. Sensitive, gas chromatography-based stereoanalysis of 4-hydroxyalkenals, toxic products of lipid peroxidation

1994 • 15 citations

Inhibition of cytosolic class 3 aldehyde dehydrogenase by antisense oligonucleotides in rat hepatoma cells

2001 • 15 citations

Reduced 4‐hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion

1994 • 15 citations

Tau modifiers as therapeutic targets for Alzheimer's disease

2004 • 14 citations

“In vitro” effect of lipid peroxidation metabolites on elongation factor-2

2006 • 14 citations

Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells

2006 • 13 citations

Enantioselective metabolism of (R)‐ and (S)‐4‐hydroxy‐2‐nonenal in rat

2005 • 13 citations

Effect of 4‐hydroxy‐2(E)‐nonenal on soybean lipoxygenase‐1

2001 • 13 citations

Deoxyguanosine Adducts of tert-4-Hydroxy-2-nonenal as Markers of Endogenous DNA Lesions

2002 • 12 citations

[4] Molecular analysis of mitogen-activated protein kinase signaling pathways induced by reactive oxygen intermediates

2002 • 10 citations

Immunological detection of 4-hydroxynonenal protein adducts in developing pontine and Purkinje neurons and in karyorrhexis in pontosubicular neuronal necrosis

2002 • 10 citations

Intracellular Ca 2+ Homeostatic Regulation and 4-Hydroxynonenal-Induced Aortic Endothelial Dysfunction

2002 • 7 citations

Experimental researches on the role of phosphoinositide‐specific phospholipase C in 4‐hydroxynonenal induced exocytosis

2003 • 6 citations

Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas

1993 • 4 citations

Biochemical and Molecular Genetic Correlation in Adenylosuccinate Lyase Deficiency

2004 • 4 citations

Analysis of Etheno 2'-Deoxyguanosine Adducts as Dosimeters of Aldo-Keto Reductase Mediated-Oxidative Stress

2003 • 3 citations