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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

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1973 • 492 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

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Free Radicals, Lipid Peroxidation and Cancer

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A new instrument for the rapid preparation of tissue slices

1980 • 287 citations

The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase

1995 • 242 citations

Precision-cut tissue slices: Applications in pharmacology and toxicology

1995 • 242 citations

Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions

1985 • 235 citations

Physiological Substrates for Rat Alcohol Dehydrogenase Classes: Aldehydes of Lipid Peroxidation, ω-Hydroxyfatty Acids, and Retinoids

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The reaction of cysteine with α,β-unsaturated aldehydes

1976 • 160 citations

Lipid Peroxidation Product, 4-Hydroxynonenal and Its Conjugate with GSH Are Excellent Substrates of Bovine Lens Aldose Reductase

1995 • 157 citations

Rat glutathione transferase 8‐8, an enzyme efficiently detoxifying 4‐hydroxyalk‐2‐enals

1986 • 155 citations

Mercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in the Rat

1995 • 139 citations

The oxidation of α-β unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases

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Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product

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Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

1992 • 125 citations

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Intrahepatic conversion of a glutathione conjugate to its mercapturic acid. Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers.

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Development of a simple incubation system for metabolism studies with precision-cut liver slices.

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Past, Present, and Future Applications of Precision-Cut Liver Slices for in Vitro Xenobiotic Metabolism

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Inhibition of medium-chain fatty acid β-oxidationinvitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid

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ChemInform Abstract: PREPARATION OF CARBOXYLIC ACIDS FROM ALDEHYDES (INCLUDING HYDROXYLATED BENZALDEHYDES) BY OXIDATION WITH CHLORITE

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Comparison of the Inactivation of Microsomal Glucose-6-Phosphatase by in Situ Lipid Peroxidation-Derived 4-Hydroxynonenal and Exogenous 4-Hydroxynonenal

1986 • 70 citations

2,3-Epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation

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Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes.

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In vivo involvement of cytochrome P450 4A family in the oxidative metabolism of the lipid peroxidation product trans-4-hydroxy-2-nonenal, using PPARα-deficient mice

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Identification of Novel Urinary Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in Rats

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Comparative metabolism of clenbuterol by rat and bovine liver microsomes and slices.

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[14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices.

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1986 • 20 citations

Formation and Metabolism of the Lipid Peroxidation Product 4-Hydroxynonenal in Liver and Small Intestine

1993 • 16 citations

Synthesis of 4‐hydroxy[4‐³H]‐2(E)‐nonen‐1‐al‐diethylacetal

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In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450

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023 Qualitative and quantitative determination of metabolites of the lipid peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor cells

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Effects of aldehyde dehydrogenase and glutathione on the degradation of (E)-4-hydroxy-2-nonenal and N-hexanal in rat liver.

1994 • 7 citations