Malarial pigment (haemozoin) : a very active 'inert' substance

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

1992 • 623 citations

An iron-carboxylate bond links the heme units of malaria pigment.

1991 • 511 citations

Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.

1993 • 501 citations

Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins

1996 • 422 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

1995 • 378 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment.

1992 • 314 citations

Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis

1988 • 257 citations

Turning on the respiratory burst

1990 • 211 citations

Intraleucocytic malaria pigment and prognosis in severe malaria

1995 • 199 citations

Possible roles of tumor necrosis factor in the pathology of malaria.

1987 • 195 citations

Chronic Granulomatous Disease: The Solving of a Clinical Riddle at the Molecular Level

1993 • 185 citations

Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection

1994 • 174 citations

Plasmodium falciparum Pigment Induces Monocytes to Release High Levels of Tumor Necrosis Factor-α and Interleukin-1β

1994 • 160 citations

Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1 alpha, and MIP-1 beta) in vitro, and altered thermoregulation in vivo.

1995 • 152 citations

Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage

1992 • 132 citations

Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

1993 • 125 citations

Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?

1991 • 124 citations

Hematopoiesis in human malaria.

1990 • 112 citations

Immune phagocytosis in murine malaria.

1979 • 104 citations

Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst.

1985 • 101 citations

Tumour necrosis factor, fever and fatality in falciparum malaria

1990 • 95 citations

Peripheral blood and bone marrow leucocytes in Gambian children with malaria: numerical changes and evaluation of phagocytosis

1988 • 83 citations

Differential induction of stress proteins and functional effects of heat shock in human phagocytes

1995 • 79 citations

Increased levels of 4‐hydroxynonenal in human monocytes fed with malarial pigment hemozoin A possible clue for hemozoin toxicity

1996 • 74 citations

MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION

1911 • 73 citations

Biochemical Characterization of Plasmodium falciparum Hemozoin

1990 • 72 citations

Plasmodium lophurae: Composition and properties of hemozoin, the malarial pigment

1979 • 71 citations

Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C

1993 • 69 citations

Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C

1993 • 68 citations

Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection

1994 • 64 citations

The Heme Moiety of Malaria Pigment (β-Hematin) Mediates the Inhibition of Nitric Oxide and Tumor Necrosis Factor-α Production by Lipopolysaccharide-Stimulated Macrophages

1995 • 64 citations

Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages

1996 • 64 citations

Immunology of human malaria. A cellular perspective

1989 • 60 citations

Two soluble antigens of Plasmodium falciparum induce tumor necrosis factor release from macrophages

1990 • 58 citations

The composition of haemozoin from Plasmodium falciparum

1989 • 58 citations

Reduced microbicidal and anti‐tumour activities of human monocytes after ingestion of Plasmodium falciparum‐infected red blood cells

1993 • 54 citations

Effects of Plasmodium vinckei Hemozoin on the Production of Oxygen Radicals and Nitrogen Oxides in Murine Macrophages

1996 • 49 citations

Pathology of Malaria

1980 • 41 citations

Hemozoin differentially modulates the production of interleukin 6 and tumor necrosis factor in murine malaria.

1995 • 41 citations

Purification and some properties of malarial pigment

1975 • 37 citations

: A potent stem cell inhibitor with potential roles in development

1992 • 35 citations

The involvement of hemozoin toxicity in depression of cellular immunity

1993 • 32 citations

Spectroscopic Investigations of Malaria Pigment

1993 • 29 citations

Haemozoin and the mode of action of blood schizontocides: More controversy

1995 • 27 citations

Characterization of the Malaria Pigment (Hemozoin) from the Avian Malaria Parasite Plasmodium lophurae*

1968 • 27 citations

MALARIAL PIGMENT (HEMATIN) AS A FACTOR IN THE PRODUCTION OF THE MALARIAL PAROXYSM

1912 • 26 citations

Inhibition of erythropoiesis by a soluble factor in murine malaria.

1989 • 26 citations

Erythrocyte Destruction Mechanisms in Malaria

1980 • 25 citations

Assessment of immune phagocytosis of Plasmodium falciparum infected red blood cells by human monocytes and polymorphonuclear leukocytes. A method for visualizing infected red blood cells ingested by phagocytes

1983 • 24 citations

Studies on the Nature of Malarial Pigment (Haemozoin)

1956 • 24 citations

Analysis of malaria pigment from Plasmodium falciparum

1994 • 23 citations

Spleen in falciparum malaria: ultrastructural study.

1987 • 20 citations

MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA

1913 • 13 citations

Direct resolution of the lattice planes of malarial pigment

1974 • 12 citations

[HUMAN BONE MARROW IN ACUTE MALARIAL INFECTIONS].

1963 • 10 citations

Plasmodium falciparum:Characterization of Toxin-Associated Proteins and Identification of a Hemoglobin Containing Parasite Cytokine Stimulator

1996 • 9 citations