Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

2003 • 1,119 citations

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

1999 • 569 citations

4-Hydroxynonenal as a bioactive marker of pathophysiological processes

2003 • 379 citations

Two Distinct Pathways of Formation of 4-Hydroxynonenal

2001 • 298 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Carbonyl Toxicology and Alzheimer's Disease

2002 • 196 citations

The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin

1999 • 187 citations

Pyrrole formation from 4-hydroxynonenal and primary amines

1993 • 172 citations

Distribution of Reducible 4-Hydroxynonenal Adduct Immunoreactivity in Alzheimer Disease is Associated with APOE Genotype

1998 • 154 citations

4‐Hydroxy‐2(E)‐Nonenal Inhibits CNS Mitochondrial Respiration at Multiple Sites

1999 • 153 citations

Preferential effects of nicotine and 4-(N-methyl- N-nitrosamino)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase a4-4 induction and increased oxidative stress in the rat brain

1998 • 126 citations

Metabolism of lipid peroxidation product, 4-hydroxynonenal (HNE) in rat erythrocytes: role of aldose reductase

2000 • 119 citations

Structural Basis of Protein-bound Endogenous Aldehydes

2003 • 89 citations

Immunochemical Evidence Supporting 2-Pentylpyrrole Formation on Proteins Exposed to 4-Hydroxy-2-nonenal

1996 • 87 citations

Acrolein inhibits respiration in isolated brain mitochondria

2001 • 84 citations

Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenal

1998 • 76 citations

Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells

2001 • 72 citations

Oxidation of 4‐hydroxy‐2‐nonenal by succinic semialdehyde dehydrogenase (ALDH5A)

2003 • 71 citations

Succinic semialdehyde dehydrogenase from mammalian brain: Subunit analysis using polyclonal antiserum

1992 • 59 citations

Autoxidative Transformation of Chiral ω6 Hydroxy Linoleic and Arachidonic Acids to Chiral 4-Hydroxy-2E-nonenal

2004 • 58 citations

Identification of metabolic pathways of the lipid peroxidation product 4‐hydroxynonenal by mitochondria isolated from rat kidney cortex

1994 • 52 citations

A synthesis of 4‐hydroxy‐2‐trans‐nonenal and 4‐(³H) 4‐hydroxy‐2‐trans‐nonenal

1997 • 50 citations

Reactions of 4-Hydroxy-2(E)-nonenal and Related Aldehydes with Proteins Studied by Carbon-13 Nuclear Magnetic Resonance Spectroscopy

1998 • 46 citations

Metabolism of 4-Hydroxy-trans-2-nonenal by Central Nervous System Mitochondria Is Dependent on Age and NAD⁺Availability

2004 • 43 citations

Mitochondrial oxidation of 4‐hydroxy‐2‐nonenal in rat cerebral cortex

2003 • 35 citations

(S)-Preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats

2001 • 33 citations

Human Brain Glyceraldehyde‐3‐Phosphate Dehydrogenase, Succinic Semialdehyde Dehydrogenase and Aldehyde Dehydrogenase Isozymes: Substrate Specificity and Sensitivity to Disulfiram

1989 • 31 citations

4-Hydroxy-2(E)-nonenal enantiomers: (S)-selective inactivation of glyceraldehyde-3-phosphate dehydrogenase and detoxification by rat glutathione S-transferase A4-4

2000 • 30 citations

Mercapturate Metabolism of 4-Hydroxy-2-Nonenal in Rat and Human Cerebrum

2003 • 27 citations

Enzymic resolution of (R)- and (S)-(E)-4-hydroxyalk-2-enals related to lipid peroxidation

1993 • 27 citations

Determination of 4-hydroxy-2-nonenal by precolumn derivatization and liquid chromatography with laser fluorescence detection

1996 • 17 citations

Determination of the rates of formation and hydrolysis of the Schiff bases formed by pyridoxal 5′-phosphate and hydrazinic compounds

2000 • 16 citations

Toxic aldehydes formed by lipid peroxidation I. Sensitive, gas chromatography-based stereoanalysis of 4-hydroxyalkenals, toxic products of lipid peroxidation

1994 • 15 citations

Oxidation of 4-hydroxynonenal in rat brain slices

2003 • 7 citations

Increasing the optical rotation of l-carbidopa by reaction with dicarbonyl compounds

1992 • 2 citations