4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

1978 • 1,624 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.

1997 • 974 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages

1980 • 851 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Lipid peroxidation and cellular damage in toxic liver injury.

1985 • 556 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Experimental liver cirrhosis induced by alcohol and iron.

1995 • 520 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

Oxidative damage and fibrogenesis

1997 • 483 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

1985 • 422 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

1993 • 334 citations

Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

1994 • 311 citations

HNE interacts directly with JNK isoforms in human hepatic stellate cells.

1998 • 301 citations

Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: Role of nitric oxide

1997 • 292 citations

Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized human low-density lipoprotein

1997 • 288 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

1998 • 267 citations

The lipid peroxidation end product 4‐hydroxy‐2,3‐nonenal up‐regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis ¹

1997 • 264 citations

Presence of 4‐hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

1998 • 249 citations

Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?

1994 • 249 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.

1990 • 244 citations

The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase

1995 • 242 citations

Signal transduction in hepatic stellate cells

1998 • 241 citations

Vitamin E dietary supplementation protects against carbon tetrachloride—induced chronic liver damage and cirrhosis

1992 • 238 citations

Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

1992 • 235 citations

Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal

1995 • 231 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Roles of Lipid Peroxidation in Modulation of Cellular Signaling Pathways, Cell Dysfunction, and Death in the Nervous System

1998 • 216 citations

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1991 • 212 citations

Chemistry and pathophysiology of oxidation of LDL

1995 • 206 citations

(E)-4-Hydroxy-2-Nonenal May be Involved in the Pathogenesis of Parkinson’s Disease

1998 • 202 citations

In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features.

1997 • 200 citations

Lipid peroxidation and cancer

1993 • 195 citations

In situ detection of lipid peroxidation by-products in chronic liver diseases

1997 • 193 citations

On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-standing cholestasis

1996 • 188 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate

1995 • 176 citations

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

1995 • 175 citations

Lipid Peroxidation Product, 4-Hydroxynonenal and Its Conjugate with GSH Are Excellent Substrates of Bovine Lens Aldose Reductase

1995 • 157 citations

4-Hydroxy-2-Nonenal Pyrrole Adducts in Human Neurodegenerative Disease

1997 • 155 citations

Multiple regulatory elements and phorbol 12-O-tetradecanoate 13-acetate responsiveness of the rat placental glutathione transferase gene.

1988 • 154 citations

Distribution of Reducible 4-Hydroxynonenal Adduct Immunoreactivity in Alzheimer Disease is Associated with APOE Genotype

1998 • 154 citations

Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid

1998 • 154 citations

The O2–producing enzyme of human neutrophils. Further properties.

1981 • 153 citations

Monoclonal Antibodies for Detection of 4-Hydroxynonenal Modified Proteins

1996 • 152 citations

Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a).

1993 • 150 citations

Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products

1967 • 149 citations

Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

1998 • 149 citations

Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells

1997 • 144 citations

Effect of Ethanol on Cytochrome P450 2E1 (CYP2E1), Lipid Peroxidation, and Serum Protein Adduct Formation in Relation to Liver Pathology Pathogenesis

1993 • 144 citations

Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte

1995 • 144 citations

Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver

1992 • 143 citations

Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen.

1994 • 142 citations

Oxidized LDLs Induce Massive Apoptosis of Cultured Human Endothelial Cells Through a Calcium-Dependent Pathway

1997 • 141 citations

Glutathione S-Transferases and Prevention of Cellular Free Radical Damage

1998 • 141 citations

Mercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in the Rat

1995 • 139 citations

Oxidative Stress Is Found in Amyloid Deposits in Systemic Amyloidosis

1997 • 134 citations

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gα_q/11

1997 • 134 citations

Effects of diffusible products of peroxidation of rat liver microsomal lipids

1979 • 131 citations

Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product

1997 • 125 citations

The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages

1992 • 124 citations

Chemotactic Activity of the Lipid Peroxidation Product 4-Hydroxynonenal and Homologous Hydroxyalkenals

1986 • 120 citations

Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome

1996 • 115 citations

Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes

1985 • 114 citations

4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine

1995 • 114 citations

Lipid Peroxidation and Biogenic Aldehydes: From the Identification of 4-Hydroxynonenal to Further Achievements in Biopathology

1998 • 112 citations

Effects of the lipidperoxidation product 4-hydroxynonenal and related aldehydes on proliferation and viability of cultured ehrlich ascites tumor cells

1985 • 109 citations

Early Alcoholic Liver Injury: Formation of Protein Adducts with Acetaldehyde and Lipid Peroxidation Products, and Expression of CYP2E1 AND CYP3A

1998 • 106 citations

Several Closely Related Glutathione S-Transferase Isozymes Catalyzing Conjugation of 4-Hydroxynonenal Are Differentially Expressed in Human Tissues

1994 • 105 citations

Increased Levels of Lipid Peroxidation Products Malondialdehyde and 4-Hydroxynonenal after Perinatal Hypoxia

1996 • 102 citations

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

1999 • 99 citations

Increased circulating products of lipid peroxidation in patients with alcoholic liver disease.

1998 • 98 citations

Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E.

1999 • 98 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

4-Hydroxynonenal and Cell Signalling

1998 • 96 citations

Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenal

1993 • 96 citations

Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency.

1997 • 96 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages.

1994 • 93 citations

Increased Levels of 4-Hydroxynonenal Modified Proteins in Plasma of Children with Autoimmune Diseases

1997 • 92 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Detection of 4-hydroxynonenal (HNE) as a physiological component in human plasma

1995 • 90 citations

Lipoproteins in normal and atherosclerotic aorta

1990 • 90 citations

Increased Circulating Products of Lipid Peroxidation in Patients with Alcoholic Liver Disease

1998 • 89 citations

Role of aldehyde metabolizing enzymes in mediating effects of aldehyde products of lipid peroxidation in liver cells

1994 • 88 citations

Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease

1997 • 86 citations

Extraction and partial characterization of dialysable products originating from the peroxidation of liver microsomal lipids and inhibiting microsomal glucose 6-phosphatase activity

1979 • 81 citations

Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein

1990 • 80 citations

UV Irradiation Activates JNK and Increases αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells

1999 • 78 citations

The Lipid Peroxidation Product 4-Hydroxynonenal is Formed by - and is able to Attract - Rat Neutrophilsin vivo

1994 • 77 citations

Detection of carbonyl functions in phospholipids of liver microsomes in CCl4- and BrCCl3-poisoned rats

1982 • 75 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene

1996 • 75 citations

Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression

1994 • 74 citations

4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase

1996 • 74 citations

α,β-Unsaturated Aldehydes Increase GlutathioneS-Transferase mRNA and Protein: Correlation with Activation of the Antioxidant Response Element

1998 • 71 citations

Cytotoxic and genotoxic effects of 4-hydroxynonenal in cerebral endothelial cells

1997 • 70 citations

Immunological evidence for increased oxidative stress in diabetic rats

1998 • 69 citations

Occurrence of Oxidatively Modified Proteins

1998 • 67 citations

Effect of 4-hydroxyalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C

1990 • 66 citations

Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte‐macrophages

1996 • 64 citations

Lipid Peroxidation and Cancer: A Critical Reconsideration

1989 • 64 citations

Quantitative Measurement of 4-Hydroxyalkenals in Oxidized Low-Density Lipoprotein by Gas Chromatography-Mass Spectrometry

1995 • 64 citations

Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.

1992 • 64 citations

Oxidized lipoproteins inhibit endothelium-dependent vasodilation. Effects of pressure and high-density lipoprotein.

1994 • 63 citations

Studies on epitopes on low-density lipoprotein modified by 4-hydroxynonenal. Biochemical characterization and determination

1992 • 62 citations

Chemotactic activity of hydroxyalkenals on rat neutrophils.

1985 • 62 citations

Induction of Procollagen Type I Gene Expression and Synthesis in Human Hepatic Stellate Cells by 4-Hydroxy-2,3-Nonenal and Other 4-Hydroxy-2,3-Alkenals Is Related to Their Molecular Structure

1996 • 61 citations

Biogenic 4‐hydroxy‐2‐nonenal activates transcription factor AP‐1 but not NF‐κB in cells of the macrophage lineage

1997 • 61 citations

Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone

1998 • 58 citations

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor

1989 • 57 citations

Inhibition of c-myc Expression Induced by 4-Hydroxynonenal, a Product of Lipid Peroxidation, in the HL-60 Human Leukemic Cell Line

1994 • 55 citations

Effect of 4-Hydroxynonenal on c-myc Expression

1987 • 55 citations

A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes.

1986 • 55 citations

Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney

1997 • 55 citations

Effect of 4-hydroxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60 cells

1996 • 55 citations

Effects of 4-Hydroxynonenal, A Product of Lipid Peroxidation, on Cell Proliferation and Ornithine Decarboxylase Activity

1991 • 55 citations

Inhibition of D1, D2, and a cyclin expression in HL-60 cells by the lipid peroxydation product 4-hydroxynonenal

1999 • 54 citations

Identification of metabolic pathways of the lipid peroxidation product 4‐hydroxynonenal by mitochondria isolated from rat kidney cortex

1994 • 52 citations

Postischemic accumulation of lipid peroxidation products in the rat brain: immunohistochemical detection of 4-hydroxy-2-nonenal modified proteins

1997 • 50 citations

Increased mitochondrial damage by lipid peroxidation in trophoblast cells of preeclamptic placentas

1997 • 50 citations

Disturbance of cell proliferation by two model compounds of lipid peroxidation contradicts causative role in proliferative senescence

1988 • 50 citations

[40] Quantitation of 4-hydroxynonenal protein adducts

1994 • 49 citations

Inhibition of calcium sequestration activity of liver microsomes by 4-hydroxyalkenals originating from the peroxidation of liver microsomal lipids

1984 • 48 citations

Effect of Oxidative Stress by Iron on 4-Hydroxynonenal Formation and Proliferative Activity In Hepatomas of Different Degrees of Differentiation

1997 • 48 citations

4-Hydroxynonenal Triggers Ca2+Influx in Isolated Rat Hepatocytes

1996 • 46 citations

Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain

1997 • 46 citations

Role of Lipid Aldehydes in Cataractogenesis: 4-Hydroxynonenal-Induced Cataract

1996 • 45 citations

1,4-Dihydroxynonene Mercapturic Acid, the Major End Metabolite of Exogenous 4-Hydroxy-2-nonenal, Is a Physiological Component of Rat and Human Urine

1998 • 43 citations

Oxidative stress induces a subset of heat shock proteins in rat hepatocytes and MH1C1 cells

1988 • 43 citations

The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1

1992 • 42 citations

4-Hydroxynonenal Specifically Inhibits c-myb but Does Not Affect c-fos Expressions in HL-60 Cells

1996 • 41 citations

Identification of Novel Urinary Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in Rats

1998 • 41 citations

Treatment of the budding yeast Saccharomyces cerevisiae with the lipid peroxidation product 4-HNE provokes a temporary cell cycle arrest in G1 phase

1998 • 39 citations

Increased lipid peroxidation in children with autoimmune diseases

1997 • 39 citations

Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations

1993 • 38 citations

Phosphatase Inhibitors Potentiate 4-Hydroxynonenal-induced Phospholipase D Activation in Vascular Endothelial Cells

1997 • 38 citations

Investigation of Lipid Peroxidation in Human Low Density Lipoprotein

1987 • 37 citations

Immunohistochemical Detection of 4-Hydroxy-2-nonenal-Modified-Protein Adducts in Human Alcoholic Liver Diseases

1998 • 35 citations

Signaling of Apoptotic Lung Injury by Lipid Hydroperoxides

1998 • 35 citations

Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis

1997 • 34 citations

Inhibition of NADPH Oxidase-Mediated Superoxide Radical Formation in PMA-Stimulated Human Neutrophils by 4-Hydroxynonenal– Binding to -SH and -NH₂Groups

1997 • 33 citations

�ber die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 1. Mitt.: Hydroxy-octenal, ein neuer Fettaldehyd

1964 • 33 citations

Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein

1996 • 30 citations

Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver

1993 • 30 citations

Modulation of Rat Liver Protein Kinase C during in Vivo CC14-Induced Oxidative Stress

1993 • 30 citations

Activation of phosphoinositide‐specific phospholipase C of rat neutrophils by the chemotactic aldehydes 4‐hydroxy‐2,3‐trans‐nonenal and 4‐hydroxy‐2,3‐trans‐octenal

1994 • 29 citations

4-Hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney

1995 • 29 citations

Stimulation of phospholipase C activity by 4-hydroxynonenal; influence of GTP and calcium concentration.

1988 • 28 citations

Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study.

1991 • 28 citations

Modulation of human T lymphocyte proliferation by 4-hydroxynonenal, the bioactive product of neutrophil-dependent lipid peroxidation

1997 • 27 citations

Increased stress parameter synthesis in the yeast Saccharomyces cerevisiae after treatment with 4‐hydroxy‐2‐nonenal¹

1997 • 27 citations

4-Hydroxynonenal, a Lipid Peroxidation Product, Induces Relaxation of Human Cerebral Arteries

1994 • 27 citations

Inhibition of the high affinity Ca2+-ATPase activity in rat liver plasma membranes following carbon tetrachloride intoxication

1990 • 26 citations

Structural requirements of aldehydes produced in LPO for the activation of the heat-shock genes in Hela cells

1995 • 26 citations

Metabolism of 4‐hydroxynonenal by the rat heptoma cell line MH₁C₁

1988 • 26 citations

Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocytochrome b

1995 • 26 citations

Immunohistochemical localization of lipoperoxidation products in normal human placenta

1997 • 26 citations

Effect of 4‐hydroxynonenal on superoxide anion production from primed human neutrophils

1996 • 25 citations

Metabolism of 4-Hydroxynonenal, a Cytotoxic Lipid Peroxidation Product, in Thymocytes as an Effective Secondary Antioxidative Defense Mechanism

1998 • 25 citations

Oxidative metabolism of 4-hydroxy-2,3-nonenal during diethyl-nitrosamine-induced carcinogenesis in rat liver

1989 • 24 citations

Intracellular Metabolism of 4-Hydroxynonenal in Primary Cultures of Rabbit Synovial Fibroblasts

1997 • 24 citations

l-Arginine infusion after ischaemia-reperfusion of rat kidney enhances lipid peroxidation

1996 • 24 citations

4-Hydroxynonenal-Induced Relaxation of Human Mesenteric Arteries1

1997 • 23 citations

Inhibition of Melanoma B16-F10 Growth by Lipid Peroxidation Product 4-Hydroxynonenal

1995 • 23 citations

Inhibition by reactive aldehydes of superoxide anion radical production in stimulated human neutrophils

1985 • 23 citations

Release of 4-hydroxynonenal, an aldehydic mediator of inflammation, during postischaemic reperfusion of the myocardium.

1993 • 23 citations

In vitro activation of heat shock transcription factor by 4-hydroxynonenal

1992 • 22 citations

Binding of the lipid peroxidation product 4‐hydroxynonenal to human polymorphonuclear leukocytes

1994 • 20 citations

Clastogenic factors in plasma of HIV-1 infected patients

1995 • 20 citations

Effects of 4-OH-2,3-trans-Nonenal on Human Erythrocyte Plasma Membrane Ca2+Pump and Passive Ca2+Permeability

1997 • 20 citations

Hepatocellular Metabolism of 4-Hydroxy-2,3-Nonenal Is Impaired in Conditions of Chronic Cholestasis

1995 • 20 citations

Ability of different hepatoma cells to metabolize 4‐hydroxynonenal

1993 • 18 citations

Assessment of growth inhibition by aldehydic lipid peroxidation products and related aldehydes by Saccharomyces cerevisiae

1995 • 17 citations

Inactivation of hepatocyte Protein Kinase C by carbon tetrachloride: Involvement of drug's metabolic activation and prooxidant effect

1990 • 16 citations

High metabolic rates of 4-hydroxynonenal in brain capillary endothelial cells during hypoxia/reoxygenation

1996 • 15 citations

Comparison of the effects of hydrogen peroxide, 4-hydroxy-2-nonenal and β-amyloid (25–35) upon calcium signalling

1998 • 15 citations

Reduced 4‐hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion

1994 • 15 citations

Selective inhibition by 4-hydroxynonenal of sphingosine-stimulated phospholipase D in NIH 3T3 cells

1992 • 12 citations

Enzymatic Pattern of Aldehyde Metabolism during HL-60 Cell Differentiation

1996 • 12 citations

Cyclic nucleotides levels in the liver of rats treated with CC14

1979 • 11 citations

4‐Hydroxynonenal induces membrane perturbations and inhibition of basal prostacyclin production in endothelial cells, and migration of monocytes.

1994 • 10 citations

Whole Blood and Plasma Concentrations of 4-Hydroxy-2-nonenal in Watanabe Heritable Hyperlipidemic Versus New Zealand White Rabbits

1994 • 10 citations

Evidences of 4-hydroxynonenal involvement in modulation of phagocyte activities.

1995 • 9 citations

High prevalence of infection with hepatitis C virus in patients with hepatic and extrahepatic malignancies

1998 • 8 citations

Changes of Adenylate Cyclase Activity in AH-130 Ascites Hepatoma of Yoshida Induced by Enrichment with Fatty Acids

1995 • 8 citations

Metabolic Rates of 4-Hydroxynonenal in Tubular and Mesangial Cells of the Kidney

1999 • 5 citations

Expression of aldehydic lipid peroxidation products in rat kidneys during warm ischemia

1997 • 5 citations

Behaviour of cyclic nucleotides and Ca2+ levels in liver tissue of rats poisoned by white phosphorus and trichlorobromomethane

1984 • 3 citations

Effect of 4-hydroxynonenal, a product of lipid peroxidation, on NK susceptibility of human K562 target cells

1997 • 3 citations

Influence of 4-hydroxynonenal on bombesin-induced stimulation of phospholipase C activity in rat liver.

1991 • 3 citations