4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

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1990 • 5,654 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Protein Oxidation and Aging

1992 • 2,687 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

1996 • 780 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium

1999 • 690 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Protein-bound acrolein: Potential markers for oxidative stress

1998 • 622 citations

Role of reactive aldehyde in cardiovascular diseases

2000 • 597 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

2001 • 568 citations

Iron-induced carcinogenesis: The role of redox regulation

1996 • 556 citations

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

1997 • 543 citations

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

1990 • 522 citations

Acrolein Is a Product of Lipid Peroxidation Reaction

1998 • 521 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1999 • 509 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

1997 • 440 citations

Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

2001 • 413 citations

Protein‐Bound Acrolein

1999 • 394 citations

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

1997 • 355 citations

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

1999 • 352 citations

Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

2001 • 349 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

1994 • 337 citations

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

1993 • 334 citations

4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress

1999 • 320 citations

Two Distinct Pathways of Formation of 4-Hydroxynonenal

2001 • 298 citations

4‐Hydroxynonenal in the Pathomechanisms of Oxidative Stress

2000 • 296 citations

Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.

1993 • 281 citations

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals

1999 • 278 citations

The lipid peroxidation end product 4‐hydroxy‐2,3‐nonenal up‐regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis ¹

1997 • 264 citations

Immunohistochemical Evidence for an Increased Oxidative Stress and Carbonyl Modification of Proteins in Diabetic Glomerular Lesions

1999 • 256 citations

Reaction of Glutathione with Conjugated Carbonyls

1975 • 256 citations

4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications

1999 • 249 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

Characterization of 4-Oxo-2-nonenal as a Novel Product of Lipid Peroxidation

2000 • 236 citations

Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal

1995 • 231 citations

Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

4-Hydroxynonenal in the Pathomechanisms of Oxidative Stress

2000 • 225 citations

Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids

1990 • 225 citations

Oxidative and nitrosative stress in acute renal ischemia

2001 • 224 citations

4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death

2000 • 215 citations

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

2001 • 214 citations

Cyclopentenone Prostaglandins as Potential Inducers of Intracellular Oxidative Stress

2001 • 214 citations

The monoclonal antibody specific for the 4‐hydroxy‐2‐nonenal histidine adduct

1995 • 206 citations

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis

1999 • 204 citations

IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal

2001 • 190 citations

The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

2001 • 184 citations

Formation of 8‐hydroxy‐2′‐deoxyguanosine and 4‐hydroxy‐2‐nonenal‐modified proteins in human renal‐cell carcinoma

1994 • 178 citations

Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat

1997 • 178 citations

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau

1997 • 173 citations

Pyrrole formation from 4-hydroxynonenal and primary amines

1993 • 172 citations

Possible involvement of the lipid-peroxidation product 4-hydroxynonenal in the formation of fluorescent chromolipids

1986 • 166 citations

Reaction of ascorbate with lysine and protein under autoxidizing conditions: formation of N.epsilon.-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate

1990 • 164 citations

4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis

1999 • 162 citations

The reaction of cysteine with α,β-unsaturated aldehydes

1976 • 160 citations

Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.

1986 • 159 citations

Lipid Peroxidation Product, 4-Hydroxynonenal and Its Conjugate with GSH Are Excellent Substrates of Bovine Lens Aldose Reductase

1995 • 157 citations

Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid

1998 • 154 citations

The Rat Quinone Reductase Antioxidant Response Element

1995 • 153 citations

Monoclonal Antibodies for Detection of 4-Hydroxynonenal Modified Proteins

1996 • 152 citations

Dry cleaning, some chlorinated solvents and other industrial chemicals IARC monographs on the evaluation of carcinogenic risks to humans. volume 63

1996 • 152 citations

Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

1998 • 149 citations

Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes

1997 • 148 citations

4-Hydroxynonenal Induces Apoptosis via Caspase-3 Activation and CytochromecRelease

2001 • 143 citations

Activation of EGF receptor by oxidized LDL

1998 • 141 citations

Characterization of Epitopes Recognized by 4-Hydroxy-2-nonenal Specific Antibodies

1995 • 138 citations

Introduction of Carbonyl Groups into Proteins by the Lipid Peroxidation Product, Malondialdehyde

1996 • 136 citations

Oxidative Stress Is Found in Amyloid Deposits in Systemic Amyloidosis

1997 • 134 citations

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gα_q/11

1997 • 134 citations

1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal.

1988 • 129 citations

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

1992 • 125 citations

Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine

1998 • 115 citations

Covalent modifications of aminophospholipids by 4-hydroxynonenal

1998 • 110 citations

Endogenous Formation of Protein Adducts with Carcinogenic Aldehydes

2001 • 108 citations

Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues

2002 • 105 citations

Thiolation of Protein-bound Carcinogenic Aldehyde

2002 • 101 citations

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

1999 • 99 citations

Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal.

1991 • 97 citations

Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

1992 • 96 citations

4-Hydroxynonenal and Cell Signalling

1998 • 96 citations

4-Hydroxy-2-nonenal, the End Product of Lipid Peroxidation, Is a Specific Inducer of Cyclooxygenase-2 Gene Expression

2000 • 95 citations

Kinetic and Structural Characterization of the Glutathione-binding Site of Aldose Reductase

2000 • 94 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Identification of Bovine Heart Cytochrome c Oxidase Subunits Modified by the Lipid Peroxidation Product 4-Hydroxy-2-nonenal^,

2002 • 88 citations

Immunochemical Evidence Supporting 2-Pentylpyrrole Formation on Proteins Exposed to 4-Hydroxy-2-nonenal

1996 • 87 citations

Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease

1997 • 86 citations

A 1-Hour Enzyme-Linked Immunosorbent Assay for Quantitation of Acrolein- and Hydroxynonenal-Modified Proteins by Epitope-Bound Casein Matrix Method

1999 • 83 citations

Formation and Properties of Reactive Aldehydes

1979 • 79 citations

Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity

1996 • 79 citations

Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin

2001 • 78 citations

Cellular Response to the Redox Active Lipid Peroxidation Products: Induction of Glutathione S-Transferase P by 4-Hydroxy-2-nonenal

1997 • 77 citations

Oxygenation of (3Z)-nonenal to (2E)-4-hydroxy-2-nonenal in the broad bean (Vicia faba L.).

1993 • 77 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase

1996 • 74 citations

α,β-Unsaturated Aldehydes Increase GlutathioneS-Transferase mRNA and Protein: Correlation with Activation of the Antioxidant Response Element

1998 • 71 citations

Structural Characterization of a 4-Hydroxy-2-alkenal-Derived Fluorophore That Contributes to Lipoperoxidation-Dependent Protein Cross-Linking in Aging and Degenerative Disease

1998 • 70 citations

Formation of a Substituted 1,N⁶-Etheno-2‘-deoxyadenosine Adduct by Lipid Hydroperoxide-Mediated Generation of 4-Oxo-2-nonenal

2000 • 70 citations

Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury.

2000 • 67 citations

Nonenzymatic peptide alpha-amidation. Implications for a novel enzyme mechanism.

1985 • 66 citations

Interaction between 4-Hydroxy-2,3-alkenals and the Platelet-derived Growth Factor-β Receptor

2000 • 65 citations

4‐Hydroxynonenal Induces Oxidative Stress and Death of Cultured Spinal Cord Neurons

2000 • 65 citations

2,3-Epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation

1993 • 64 citations

Structure of a Fluorescent Compound Formed from 4-Hydroxy-2-nonenal and N^α-Hippuryllysine: A Model for Fluorophores Derived from Protein Modifications by Lipid Peroxidation

1998 • 63 citations

Studies on epitopes on low-density lipoprotein modified by 4-hydroxynonenal. Biochemical characterization and determination

1992 • 62 citations

Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain

2000 • 58 citations

Site-Specific Inactivation of Aldose Reductase by 4-Hydroxynonenal

1998 • 57 citations

Role of p38 Mitogen-Activated Protein Kinase in the 4-Hydroxy-2-Nonenal-Induced Cyclooxygenase-2 Expression

2002 • 51 citations

Postischemic accumulation of lipid peroxidation products in the rat brain: immunohistochemical detection of 4-hydroxy-2-nonenal modified proteins

1997 • 50 citations

Increased mitochondrial damage by lipid peroxidation in trophoblast cells of preeclamptic placentas

1997 • 50 citations

Detection of lipofuscin‐like fluorophore in oxidized human low‐density lipoprotein

2000 • 46 citations

Soybean Lipoxygenase-1 Oxidizes 3Z-Nonenal

1998 • 43 citations

�ber die Reaktion von Protein-SH-Gruppen mit 4-Hydroxypentenal

1971 • 43 citations

4-Hydroxynonenal Specifically Inhibits c-myb but Does Not Affect c-fos Expressions in HL-60 Cells

1996 • 41 citations

Enhanced Hepatic Lipid Peroxidation in Patients With Primary Biliary Cirrhosis

2000 • 41 citations

4-Hydroxy-2-nonenal-Trapping ELISA: Direct Evidence for the Release of a Cytotoxic Aldehyde from Oxidized Low Density Lipoproteins

1995 • 38 citations

4-Hydroxy-2-nonenal Is a Powerful Endogenous Inhibitor of Endothelial Response

2001 • 37 citations

4-Hydroxy-2-nonenal Cytotoxicity in Renal Proximal Tubular Cells: Protein Modification and Redox Alteration

1996 • 36 citations

Purification, Mass Spectrometric Characterization, and Covalent Modification of Murine Glutathione S-Transferases

1995 • 34 citations

4-Hydroxynonenal Inhibits Interleukin-1βConverting Enzyme

1997 • 24 citations

Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells

2001 • 19 citations

Action of lipid peroxidation products on phosphoinositide specific phospholipase c

1993 • 14 citations

Immunological detection of 4-hydroxynonenal protein adducts in developing pontine and Purkinje neurons and in karyorrhexis in pontosubicular neuronal necrosis

2002 • 10 citations