Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

The oxidation hypothesis of atherosclerosis

1994 • 1,418 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Cell Biology of Atherosclerosis

1995 • 982 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Stability and Instability: Two Faces of Coronary Atherosclerosis

1996 • 910 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

1995 • 700 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Pathological mechanisms in carbon tetrachloride hepatotoxicity

1985 • 422 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression

1991 • 384 citations

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.

1986 • 380 citations

Lipid peroxides and atherosclerosis.

1989 • 366 citations

Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species

1996 • 332 citations

Methods for determination of aldehydic lipid peroxidation products

1989 • 330 citations

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

1995 • 311 citations

Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis

1994 • 248 citations

Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells

1996 • 248 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal

1995 • 231 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

1992 • 210 citations

Lipid peroxidation and cancer

1993 • 195 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.

1992 • 169 citations

Induction of Vascular Endothelial Growth Factor in Balloon-Injured Baboon Arteries

1997 • 158 citations

Apoptosis of Rat Vascular Smooth Muscle Cells Is Regulated by p53-Dependent and -Independent Pathways

1995 • 155 citations

Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a).

1993 • 150 citations

Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells.

1995 • 143 citations

Oxidized Low Density Lipoprotein and Lysophosphatidylcholine Stimulate Cell Cycle Entry in Vascular Smooth Muscle Cells

1996 • 142 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Carotenoids in human health

1992 • 134 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Cytotoxicity, thiol depletion and inhibition of O⁶-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts

1985 • 122 citations

The Role of Beta‐Carotene in the Prevention of Cardiovascular Disease

1993 • 122 citations

Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation

1992 • 106 citations

Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenal

1993 • 96 citations

Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal

1991 • 93 citations

Detection of 4-hydroxynonenal (HNE) as a physiological component in human plasma

1995 • 90 citations

Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis.

1995 • 89 citations

Proliferative and cytotoxic effects of mildly oxidized low-density lipoproteins on vascular smooth-muscle cells

1995 • 84 citations

4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium

1995 • 84 citations

Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity

1996 • 79 citations

The Lipid Peroxidation Product 4-Hydroxynonenal is Formed by - and is able to Attract - Rat Neutrophilsin vivo

1994 • 77 citations

Differences in Proliferation of Primary Cultures of Vascular Smooth Muscle Cells Taken from Male and Female Rats

1980 • 74 citations

Effects of platelet-contained growth factors (PDGF, EGF, IGF-I, and TGF-β) on DNA synthesis in porcine aortic smooth muscle cells in culture

1992 • 58 citations

Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA

1993 • 48 citations

Lipid peroxidation-dependent and -independent protein thiol modifications in isolated rat hepatocytes: Differential effects of vitamin E and disulfiram

1989 • 38 citations

Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations

1993 • 38 citations

EPR method for the measurement of cellular sulfhydryl groups

1991 • 35 citations

Acute toxicity oftrans‐5‐hydroxy‐2‐nonenal in fisher 344 rats

1992 • 32 citations

Acute toxicity oftrans‐5‐hydroxy‐2‐nonenal in fisher 344 rats

1993 • 25 citations

Aliphatic aldehydes inhibit the proliferative response of human peripheral blood lymphocytes to phytohemagglutinin and alloantigens

1987 • 21 citations

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

1995 • 16 citations

Action of lipid peroxidation products on phosphoinositide specific phospholipase c

1993 • 14 citations