Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.

Antibodies, a laboratory manual

1989 • 12,929 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

Theta, a new class of glutathione transferases purified from rat and man

1991 • 743 citations

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

1978 • 686 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 530 citations

Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes

1993 • 449 citations

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

1985 • 422 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 320 citations

Glutathione Transferases As Markers Of Preneoplasia And Neoplasia

1989 • 308 citations

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

1992 • 277 citations

A critical review of the literature on acrolein toxicity

1985 • 277 citations

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

1987 • 163 citations

Animal Cell Culture: A Practical Approach

1987 • 157 citations

Rat glutathione transferase 8‐8, an enzyme efficiently detoxifying 4‐hydroxyalk‐2‐enals

1986 • 155 citations

Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids

1984 • 150 citations

Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines.

1988 • 137 citations

Natural and artificial bleomycins: chemistry and antitumour activities

1971 • 110 citations

Tissue-specific expression of the rat glutathione S-transferases.

1983 • 108 citations

Expression of class Pi glutathione transferase in human malignant melanoma cells

1987 • 105 citations

Heterologous expression of the allelic variant mu-class glutathione transferases μ and ψ

1991 • 96 citations

Cloning and heterologous expression of cDNA encoding class Alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds

1992 • 86 citations

Participation of the phenolic hydroxyl group of Tyr-8 in the catalytic mechanism of human glutathione transferase P1-1

1992 • 86 citations

Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes

1990 • 77 citations

The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release.

1986 • 75 citations

Expression of human glutathione S-transferase 2 in Escherichia coli. Immunological comparison with the basic glutathione S-transferases isoenzymes from human liver

1987 • 63 citations

Inactivation of the genotoxic aldehyde acrolein by human glutathione transferases of classes alpha, mu, and pi.

1990 • 60 citations

Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation.

1976 • 50 citations

Origin and cytotoxic properties of base propenals derived from DNA.

1985 • 50 citations

Conversion of melphalan to 4-(glutathionyl)phenylalanine. A novel mechanism for conjugation by glutathione-S-transferases.

1987 • 49 citations

Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines

1984 • 48 citations

Malondialdehyde precursors in gamma-irradiated DNA, deoxynucleotides and deoxynucleosides

1985 • 45 citations

Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases

1992 • 45 citations

Metabolism of Xenobiotics in Hepatocyte Nodules

1987 • 27 citations