Conditional Expression of 15-Lipoxygenase-1 Inhibits the Selenoenzyme Thioredoxin Reductase

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate

1999 • 1,279 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Thioredoxin reductase

2000 • 543 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Human Placenta Thioredoxin Reductase

1998 • 519 citations

Intracellular unesterified arachidonic acid signals apoptosis

2000 • 423 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.

2000 • 378 citations

Suicide Inactivation of Peroxidases and the Challenge of Engineering More Robust Enzymes

2002 • 345 citations

Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

1995 • 315 citations

Two Distinct Pathways of Formation of 4-Hydroxynonenal

2001 • 298 citations

Lipoxygenase modulation to reverse carcinogenesis.

2001 • 271 citations

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

1998 • 267 citations

The 15-lipoxygenase-1 product 13- S -hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells

2003 • 233 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

Decomposition of linoleic acid hydroperoxides. Enzymic reactions compared with nonenzymic

1975 • 224 citations

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

2001 • 209 citations

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.

1982 • 202 citations

Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue

1998 • 199 citations

IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal

2001 • 190 citations

15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.

2000 • 182 citations

15-LOX-1: a Novel Molecular Target of Nonsteroidal Anti-inflammatory Drug-Induced Apoptosis in Colorectal Cancer Cells

2000 • 168 citations

Thioredoxin as a Molecular Target of Cyclopentenone Prostaglandins

2003 • 167 citations

Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase

2003 • 164 citations

Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers

1999 • 162 citations

Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells during Apoptosis and Cell Differentiation

1998 • 145 citations

Interactions of Quinones with Thioredoxin Reductase

2004 • 136 citations

Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis

2001 • 133 citations

The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells

1996 • 131 citations

Dual Function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of Cyclooxygenase and Induction of NSAID-Activated Gene

2002 • 127 citations

Evidence That Arachidonate 15-Lipoxygenase 2 Is a Negative Cell Cycle Regulator in Normal Prostate Epithelial Cells

2002 • 125 citations

Identification of ligands and coligands for the ecdysone-regulated gene switch

2000 • 116 citations

Expression of 15-lipoxygenase-1 in human colorectal cancer.

1999 • 116 citations

Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging

2000 • 112 citations

Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis.

1999 • 104 citations

Clinical flow cytometry: Principles and application

1994 • 100 citations

15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway

2001 • 98 citations

Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells

2000 • 91 citations

Clinical flow cytometry : principles and application

1993 • 91 citations

Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells

2002 • 87 citations

4-hydroxynonenal inhibits glutathione peroxidase: protection by glutathione

1999 • 73 citations

15‐hydroxy‐eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator‐activated receptor gamma‐dependent pathway

2003 • 71 citations

Selenium and the thioredoxin redox system: effects on cell growth and death.

1997 • 71 citations

The effect of 15-Lipoxygenase-1 expression on cancer cells

2002 • 68 citations

Different Suicide Inactivation Processes for the Peroxidase and Cyclooxygenase Activities of Prostaglandin Endoperoxide H Synthase-1

2001 • 43 citations

Peroxidase Self-inactivation in Prostaglandin H Synthase-1 Pretreated with Cyclooxygenase Inhibitors or Substituted with Mangano Protoporphyrin IX

2001 • 33 citations

Leukotriene B₄Production in Human Mononuclear Phagocytes Is Modulated by Interleukin-4-Induced 15-Lipoxygenase

2002 • 31 citations

Differential effect of hydroxyurea on a ribonucleotide reductase system.

1978 • 10 citations