4-Hydroxy-2-Nonenal Enhances Fibronectin Production by IMR-90 Human Lung Fibroblasts Partly via Activation of Epidermal Growth Factor Receptor-Linked Extracellular Signal-Regulated Kinase p44/42 Pathway

Asthma

2000 • 1,717 citations

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1989 • 1,151 citations

Systemic oxidative stress in asthma, COPD, and smokers.

1996 • 781 citations

Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease.

1996 • 497 citations

Lipid peroxidation and tissue damage.

1999 • 417 citations

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

2000 • 362 citations

Lipid peroxidation products and antioxidants in human disease.

1998 • 357 citations

HNE interacts directly with JNK isoforms in human hepatic stellate cells.

1998 • 301 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Asthma: a disease remodeling the airways

1992 • 262 citations

Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy

1998 • 249 citations

Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness.

1988 • 196 citations

Expired Breath Hydrogen Peroxide Is a Marker of Acute Airway Inflammation in Pediatric Patients with Asthma

1993 • 184 citations

Glutathione Redox System in Oxidative Lung Injury

1999 • 174 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

Activation of EGF receptor by oxidized LDL

1998 • 141 citations

Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells

2000 • 117 citations

Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients

1994 • 107 citations

Fibronectin

1992 • 106 citations

GSH rescue by N-acetylcysteine

1991 • 100 citations

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

1999 • 99 citations

Annual Scientific Meeting of ASCEPT, 1999 Role Of Human Airway Smooth Muscle In Altered Extracellular Matrix Production In Asthma

2001 • 96 citations

Lipid Peroxidation Products and Antioxidants in Human Disease

1998 • 85 citations

Transforming Growth Factor- α Deficiency Reduces Pulmonary Fibrosis in Transgenic Mice

1999 • 82 citations

Neutrophil Retention in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

1991 • 80 citations

Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase.

1999 • 76 citations

4-Hydroxynonenal-Induced Cell Death in Murine Alveolar Macrophages

1996 • 75 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis.

1999 • 70 citations

4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.

1999 • 56 citations

Cytotoxicity of linoleic acid peroxide, malondialdehyde and 4-hydroxynonenal towards human fibroblasts

1991 • 53 citations

Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4‐hydroxynonenal

1994 • 53 citations

Evidence of oxidative stress in asthma and COPD: potential inhibitory effect of theophylline

2000 • 50 citations

Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells.

1997 • 50 citations

4-Hydroxynonenal Triggers Ca2+Influx in Isolated Rat Hepatocytes

1996 • 46 citations

A Possible Involvement of Oxidative Lung Injury in Endotoxin-Induced Bronchial Hyperresponsiveness to Substance P in Guinea Pigs

1998 • 14 citations

Effects of the calcium ionophore A23187 on airway responsiveness to histamine and substance P in guinea pigs

1997 • 6 citations