Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Cytotoxicity and genotoxicity of lipid-oxidation products

1993 • 802 citations

Fructose transporter in human spermatozoa and small intestine is GLUT5.

1992 • 527 citations

Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging

1992 • 521 citations

An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications

1992 • 431 citations

The enzymes of detoxication.

1990 • 419 citations

Predominant osmotically active organic solutes in rat and rabbit renal medullas.

1986 • 382 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Nonenzymatic Glycosylation, the Maillard Reaction and the Aging Process

1990 • 335 citations

Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus

1975 • 326 citations

Complications: Neuropathy, Pathogenetic Considerations

1992 • 301 citations

The involvement of aldose reductase in diabetic complications

1988 • 296 citations

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.

1992 • 285 citations

Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

1992 • 235 citations

Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions

1985 • 235 citations

Identification of Fructose 3-Phosphate in the Lens of Diabetic Rats

1990 • 208 citations

Maillard Reactions in Chemistry, Food and Health

1994 • 197 citations

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

1992 • 193 citations

Le mécanisme de la transformation de glucose en fructose par les vésicules séminales

1956 • 180 citations

Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

1987 • 175 citations

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

1987 • 163 citations

Glomerular Polyol Accumulation in Diabetes and its Prevention by Oral Sorbinil

1984 • 160 citations

Elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats

1990 • 142 citations

�ber die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 3. Mitt.: Synthese von homologen 4-Hydroxy-2-alkenalen, II

1967 • 133 citations

Comparison of the mutagenicities of malondialdehyde and the side products formed during its chemical synthesis.

1980 • 132 citations

Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.

1993 • 116 citations

Detection of 3-deoxyfructose and 3-deoxyglucosone in human urine and plasma: Evidence for intermediate stages of the maillard reaction in vivo

1992 • 115 citations

Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inositol.

1987 • 115 citations

Role of aldose reductase in the development of diabetes-associated complications

1985 • 105 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

1992 • 105 citations

Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.

1992 • 105 citations

The crystal structure of the aldose reductase.NADPH binary complex.

1992 • 101 citations

The crystal structure of the aldose reductase.NADPH binary complex.

1992 • 88 citations

Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts

1992 • 86 citations

Distribution of alcohol and sorbitol dehydrogenases

1993 • 83 citations

Mechanism of Aldose Reductase Inhibition: Binding of NADP+/NADPH and Alrestatin-like Inhibitors

1994 • 77 citations

Osmotic regulation of aldose reductase protein synthesis in renal medullary cells

1989 • 77 citations

Menstrual cycle effect on plasma lipids

1988 • 76 citations

Hyperglycemia-induced Intracellular Depletion of Ascorbic Acid in Human Mononuclear Leukocytes

1983 • 76 citations

Human carbonyl and aldose reductases: New catalytic functions in tetrahydrobiopterin biosynthesis

1991 • 74 citations

Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil

1984 • 74 citations

Aldose and Aldehyde Reductase Exhibit Isocorticosteroid Reductase Activity

1983 • 73 citations

Polymerization of proteins caused by reaction with sugars and the formation of 3-deoxyglucosone under physiological conditions.

1988 • 69 citations

Effect of Aldose Reductase Inhibitor (Sorbinil) on Integration of Polyol Pathway, Pentose Phosphate Pathway, and Glycolytic Route in Diabetic Rat Lens

1986 • 67 citations

Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.

1990 • 66 citations

Effect of 4-hydroxyalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C

1990 • 66 citations

Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange.

1990 • 63 citations

Kinetic and structural effects of activation of bovine kidney aldose reductase

1989 • 62 citations

Structural and functional changes in LDL after modification with both 4-hydroxynonenal and malondialdehyde

1993 • 62 citations

Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity.

1994 • 60 citations

Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase-mediated acetaldehyde oxidation by trans-4-hydroxy-2-nonenal

1991 • 53 citations

The pathogenesis and prevention of diabetic neuropathy and nephropathy

1988 • 47 citations

Immunoquantitation of aldose reductase in human tissues

1989 • 39 citations

Quantitative determination of human aldose reductase by enzyme-linked immunosorbent assay

1993 • 39 citations

Stereospecificity of the hydrogen transfer catalyzed by human placental aldose reductase

1977 • 32 citations

Immunochemical characterization of aldo‐keto reductases from human tissues

1985 • 31 citations

Hyperglycemia-induced intracellular depletion of ascorbic acid in human mononuclear leukocytes

1983 • 28 citations

Effects of substituents on the rates of disproportionation of substituted phenylglyoxals in alkaline solution

1972 • 27 citations

Effect of aldose reductase inhibitor (sorbinil) on integration of polyol pathway, pentose phosphate pathway, and glycolytic route in diabetic rat lens

1986 • 26 citations

Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase

1989 • 26 citations

Stereochemistry of reduction of D-glyceraldehyde catalyzed by a nicotinamide adenine dinucleotide phosphate dependent dehydrogenase from skeletal muscle

1973 • 25 citations

Selective oxidation of histidine residues in proteins or peptides through the copper(II)-catalysed autoxidation of glucosone

1992 • 24 citations

Fluorescence energy transfer studies of the interaction between adrenodoxin and cytochrome c.

1981 • 23 citations

Aldose reductase inhibitors and prevention of galactose cataracts in rats.

1989 • 22 citations

Substrate Specificity of Reduced and Oxidized Forms of Human Aldose Reductase

1993 • 18 citations

Effects of glycemic control and aldose reductase inhibition on nerve conduction velocity

1985 • 16 citations

Aldose and aldehyde reductases from human kidney cortex and medulla

1993 • 15 citations

4-Hydroxynonenal reduces junctional communication between endothelial cells in culture*1

1991 • 13 citations

Sepiapterin Reductase and ALR2 (“Aldose Reductase”) from Bovine Brain

1993 • 1 citations