Cardiac Mitochondrial NADP+-isocitrate Dehydrogenase Is Inactivated through 4-Hydroxynonenal Adduct Formation

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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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Control of Mitochondrial Redox Balance and Cellular Defense against Oxidative Damage by Mitochondrial NADP+-dependent Isocitrate Dehydrogenase

2001 • 504 citations

Glutathione in Defense and Signaling

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Oxidative Stress in Arterial Hypertension

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1998 • 350 citations

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

1998 • 350 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

1987 • 300 citations

4‐Hydroxynonenal in the Pathomechanisms of Oxidative Stress

2000 • 296 citations

Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

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Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

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NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy

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Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

1998 • 226 citations

Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal

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4-Hydroxynonenal in the Pathomechanisms of Oxidative Stress

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Proton‐translocating transhydrogenase and NAD‐ and NADP‐linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria

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Role of 4-Hydroxynonenal in Modification of Cytochrome c Oxidase in Ischemia/Reperfused Rat Heart

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Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

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Inactivation of NADP + -dependent isocitrate dehydrogenase by nitric oxide

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Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal

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Cysteinyl peptides of pig heart NADP-dependent isocitrate dehydrogenase that are modified upon inactivation by N-ethylmaleimide

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Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO·

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Cloning of a cDNA encoding bovine mitochondrial NADP+-specific isocitrate dehydrogenase and structural comparison with its isoenzymes from different species

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Localization of a Mitochondrial Type of NADP-dependent Isocitrate Dehydrogenase in Kidney and Heart of Rat: An Immunocytochemical and Biochemical Study

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Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation.

1996 • 16 citations

Reduced 4‐hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion

1994 • 15 citations

Molecular cloning of the cDNA of mouse mitochondrial NADP-dependent isocitrate dehydrogenase and the expression of the gene during lymphocyte activation

1996 • 13 citations