4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines
Data up to Jan 2025
Total Citations Per Year
Abstract
References (66)
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
1994 • 7,043 citations
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
1991 • 6,550 citations
A survey of telomerase activity in human cancer
1997 • 2,747 citations
Role of Oxidative Modifications in Atherosclerosis
2004 • 2,558 citations
Oxidative stress shortens telomeres
2002 • 2,362 citations
Oxidative stress in neurodegeneration: cause or consequence?
2004 • 1,803 citations
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 • 1,607 citations
Origin of Concatemeric T7DNA
1972 • 1,591 citations
Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster
1994 • 1,461 citations
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression
1987 • 1,180 citations
Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes
2004 • 1,017 citations
TELOMERE LENGTH REGULATION
1996 • 1,010 citations
Direct activation of TERT transcription by c-MYC
1999 • 871 citations
Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?
1995 • 849 citations
Oxidative stress-related molecules and liver fibrosis
2001 • 768 citations
Oxidative DNA damage and senescence of human diploid fibroblast cells.
1995 • 697 citations
Recruitment of p300/CBP in p53-Dependent Signal Pathways
1997 • 671 citations
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
1994 • 617 citations
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
1999 • 545 citations
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
2000 • 485 citations
Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
2002 • 475 citations
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter
1999 • 473 citations
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication
1998 • 436 citations
Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
1997 • 427 citations
Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
1999 • 418 citations
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.
1985 • 414 citations
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
2000 • 362 citations
Sequence-specific DNA Cleavage by Fe2+-mediated Fenton Reactions Has Possible Biological Implications
1999 • 329 citations
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
2001 • 319 citations
A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.
1993 • 294 citations
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
2001 • 270 citations
Differentiation of immortal cells inhibits telomerase activity.
1995 • 269 citations
Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
2000 • 257 citations
4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications
1999 • 249 citations
Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.
1997 • 248 citations
Oxidative stress and vascular damage in hypertension
2000 • 240 citations
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
1998 • 237 citations
Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1.
2000 • 216 citations
Frequent mutations in the p53 gene in human myeloid leukemia cell lines
1992 • 197 citations
Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc.
1994 • 159 citations
Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase
2000 • 131 citations
p53-dependent Down-regulation of Telomerase Is Mediated by p21
2004 • 130 citations
Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.
1996 • 127 citations
A novel quantitative 'stretch PCR assay', that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias.
1996 • 122 citations
Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.
1984 • 117 citations
Effects of Oxidative Damage and Telomerase Activity on Human Articular Cartilage Chondrocyte Senescence
2004 • 115 citations
Repression by the Mad(Mxi1)-Sin3 complex
1998 • 110 citations
Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation
1991 • 93 citations
Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation
2005 • 90 citations
Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.
2001 • 85 citations
Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
1999 • 85 citations
Supression of telomerase activity in HL60 cells after treatment with differentiating agents.
1996 • 72 citations
4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line
2004 • 61 citations
Rapid, quantitative nonisotopic assay for telomerase activity in human tumors
1998 • 60 citations
4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.
1999 • 56 citations
Inhibition of c-myc Expression Induced by 4-Hydroxynonenal, a Product of Lipid Peroxidation, in the HL-60 Human Leukemic Cell Line
1994 • 55 citations
Inhibition of D1, D2, and a cyclin expression in HL-60 cells by the lipid peroxydation product 4-hydroxynonenal
1999 • 54 citations
Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3
1991 • 34 citations
4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells
2002 • 32 citations
Establishment of quantitative reverse transcription–polymerase chain reaction assays for human telomerase-associated genes
2000 • 32 citations
Dynamics of Myc/Max/Mad Expression during Luteinization of Primate Granulosa Cellsin Vitro: Association with Periovulatory Proliferation
2003 • 26 citations
Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells
2002 • 21 citations
Analysis of E-box DNA binding during myeloid differentiation reveals complexes that contain Mad but not Max
1997 • 13 citations
Antisense Sp1 oligodeoxynucleotide decreases telomerase activity by inhibiting hTERT mRNA expression in Jurkat T cells.
2003 • 11 citations
How to Inhibit Telomerase Activity for Cancer Therapy
2002 • 10 citations
Effect of bioactive aldehydes on cell proliferation and c-myc expression in HL-60 human leukemic cells.
2000 • 8 citations