Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

1997 • 392 citations

Significant Levels of Oxidants are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

1997 • 391 citations

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

1989 • 383 citations

Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

1993 • 334 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Oxygen-derived free radicals and myocardial reperfusion injury: An overview

1991 • 303 citations

Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism.

1984 • 206 citations

Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart.

1986 • 187 citations

O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase

1987 • 183 citations

Vasodilator Effects of Endothelin-Converting Enzyme Inhibition and Endothelin ET _A Receptor Blockade in Chronic Heart Failure Patients Treated With ACE Inhibitors

1996 • 180 citations

Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart.

1987 • 179 citations

The role of glutathione status in the protection against ischaemic and reperfusion damage: Effects of N-acetyl cysteine

1988 • 178 citations

Susceptibility of Glucose-6-Phosphate Dehydrogenase Modified by 4-Hydroxy-2-nonenal and Metal-Catalyzed Oxidation to Proteolysis by the Multicatalytic Protease

1994 • 172 citations

4-Hydroxynonenal inhibits Na+-K+-ATPase

1996 • 164 citations

Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids

1984 • 150 citations

A Redox-Based Mechanism for Cardioprotection Induced by Ischemic Preconditioning in Perfused Rat Heart

1995 • 141 citations

Characterization of Epitopes Recognized by 4-Hydroxy-2-nonenal Specific Antibodies

1995 • 138 citations

Spin trapping of oxygen and carbon-centered free radicals in ischemic canine myocardium

1987 • 126 citations

4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

1990 • 121 citations

Direct measurement of myocardial free radical generation in an in vivo model: Effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase

1992 • 110 citations

Measurement of Na(+)-K+ pump current in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Inhibition of the pump by oxidant stress.

1993 • 108 citations

Myocardial glutathione depletion impairs recovery after short periods of ischemia.

1989 • 103 citations

Stunning: A Radical Re-view

1992 • 85 citations

4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium

1995 • 84 citations

Electrophysiological Effects of 4-Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, on Isolated Rat Ventricular Myocytes

1995 • 77 citations

Stunning: A radical re-view

1991 • 66 citations

Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia

1992 • 61 citations

Superoxide dismutase and the reduction of reperfusion-induced arrhythmias: In vivo dose-response studies in the rat

1987 • 43 citations

Relative time-profiles for free radical trapping, coronary flow, enzyme leakage, arrhythmias, and function during myocardial reperfusion

1994 • 41 citations

Evolution of free radical formation during low-flow ischemia and reperfusion in isolated rat heart

1990 • 40 citations

Anti-La (SS-B) but not anti-Ro52 (SS-A) antibodies cross-react with laminin—a role in the pathogenesis of congenital heart block?

1995 • 38 citations

Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.

1981 • 35 citations

Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of β-adrenoceptor function in the heart by oxidative stress

1989 • 34 citations

Modulation of cardiac Na(+)-K+ pump current: role of protein and nonprotein sulfhydryl redox status

1995 • 30 citations

Depletion of myocardial glutathione: its effects on heart function and metabolism during ischaemia and reperfusion

1988 • 28 citations

Cumene hydroperoxide, an agent inducing lipid peroxidation, and 4-hydroxy-2,3-nonenal, a peroxidation product, cause coronary vasodilatation in perfused rat hearts by a cyclic nucleotide independent mechanism

1990 • 26 citations

Myocardial protection with verapamil during ischaemia and reperfusion: dissociation between myocardial salvage and the degree of ATP depletion during ischaemia

1991 • 26 citations

Myocardial microdialysis of salicylic acid to detect hydroxyl radical generation during ischemia

1995 • 17 citations

Discrepancy between biochemical normalization and morphological recovery of jejunal mucosa during postischemic reperfusion in presence of the xanthine oxidase inhibitor oxypurinol.

1991 • 16 citations

Microdialysis study of ischemia-induced hydroxyl radicals in the canine heart

1994 • 13 citations

Quantitative assessment of free-radical generation during ischemia and reperfusion in the isolated rabbit heart

1993 • 13 citations

Oxidant Stress and the Heart

1995 • 9 citations

[Free radical centers in isolated rat heart tissue in a normal state, in ischemia, and reperfusion].

1993 • 5 citations