OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

IMMUNOLOGY OF MULTIPLE SCLEROSIS

2005 • 2,099 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?

2001 • 1,237 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

2001 • 864 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

CD28-mediated co-stimulation: a quantitative support for TCR signalling

2003 • 713 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Asthma: an epidemic of dysregulated immunity

2002 • 613 citations

Multiple sclerosis: a two-stage disease

2001 • 602 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

2002 • 507 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Cutting Edge: Persistence of Transferred Lymphocyte Clonotypes Correlates with Cancer Regression in Patients Receiving Cell Transfer Therapy

2004 • 454 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

2001 • 438 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Costimulatory regulation of T cell function

1999 • 391 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.

1995 • 363 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation.

1989 • 340 citations

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

2004 • 320 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis

2005 • 317 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

2001 • 281 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

Cross-Talk between Activated Human NK Cells and CD4+ T Cells via OX40-OX40 Ligand Interactions

2004 • 262 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 247 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

2003 • 235 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

2003 • 226 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Persistence of Multiple Tumor-Specific T-Cell Clones Is Associated with Complete Tumor Regression in a Melanoma Patient Receiving Adoptive Cell Transfer Therapy

2004 • 217 citations

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

1999 • 214 citations

The Benefit/Risk Profile of TNF-Blocking Agents: Findings of a Consensus Panel

2005 • 211 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

2001 • 207 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

2004 • 192 citations

Plasmacytoid Dendritic Cells Regulate Th Cell Responses through OX40 Ligand and Type I IFNs

2004 • 191 citations

Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.

1996 • 180 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

Manipulation of costimulatory signals to enhance antitumor T-cell responses

1995 • 177 citations

Costimulation of CD8 T Cell Responses by OX40

2004 • 176 citations

Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein

1999 • 172 citations

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

1997 • 172 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Selective depletion of myelin–reactive T cells with the anti–OX–40 antibody ameliorates autoimmune encephalomyelitis

1996 • 159 citations

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

2004 • 159 citations

4-1BB and OX40 Act Independently to Facilitate Robust CD8 and CD4 Recall Responses

2004 • 151 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Control of Syngeneic Tumor Growth by Activation of CD8+ T Cells: Efficacy Is Limited by Migration Away from the Site and Induction of Nonresponsiveness

1999 • 146 citations

T-Cell Activation Marker Expression on Tumor-Infiltrating Lymphocytes As Prognostic Factor in Cutaneous Malignant Melanoma

2004 • 145 citations

Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax.

1991 • 141 citations

Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.

1996 • 139 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma

2003 • 135 citations

Interleukin‐12 and B7.1 co‐stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors

1996 • 130 citations

IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells

2001 • 125 citations

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

2004 • 122 citations

Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases

2002 • 120 citations

Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

1997 • 119 citations

Cutting Edge: Pulmonary Immunopathology Mediated by Antigen-Specific Expression of TNF-α by Antiviral CD8+ T Cells

2004 • 119 citations

Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand

2004 • 118 citations

PATHOGENESIS OF RHEUMATOID ARTHRITIS

2001 • 118 citations

4-1BB and OX40 Dual Costimulation Synergistically Stimulate Primary Specific CD8 T Cells for Robust Effector Function

2004 • 116 citations

OX40 Ligation Enhances Primary and Memory Cytotoxic T Lymphocyte Responses in an Immunotherapy for Hepatic Colon Metastases

2002 • 115 citations

Structural and functional consequences of alveolar cell recognition by CD8(+) T lymphocytes in experimental lung disease.

1998 • 114 citations

Strong and Selective Glomerular Localization of CD134 Ligand and TNF Receptor-1 in Proliferative Lupus Nephritis

2000 • 110 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

2003 • 109 citations

A Critical Role for OX40 in T Cell–mediated Immunopathology during Lung Viral Infection

2003 • 108 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

Death and survival: viral regulation of TNF signaling pathways

2003 • 108 citations

Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis

2001 • 108 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

Feline immunodeficiency virus targets activated CD4 ⁺ T cells by using CD134 as a binding receptor

2004 • 102 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection

2000 • 96 citations

Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.

1994 • 95 citations

New therapies for rheumatoid arthritis

2005 • 94 citations

Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL

2003 • 93 citations

The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo

2003 • 91 citations

Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134)

2002 • 90 citations

Adenovirus Vector-Mediatedin VivoGene Transfer of OX40 Ligand to Tumor Cells Enhances Antitumor Immunity of Tumor-Bearing Hosts

2004 • 88 citations

OX40 Expressed on Fresh Leukemic Cells From Adult T-Cell Leukemia Patients Mediates Cell Adhesion to Vascular Endothelial Cells: Implication for the Possible Involvement of OX40 in Leukemic Cell Infiltration

1997 • 85 citations

OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen

2005 • 84 citations

Expression of the T-Cell Activation Antigen, OX-40, Identifies Alloreactive T Cells in Acute Graft-Versus-Host Disease

1997 • 83 citations

Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: A possible role in asthma?

2004 • 83 citations

Immunotherapy with OX40L‐Fc or anti‐CTLA‐4 enhances local tissue responses and killing of Leishmania donovani

2004 • 82 citations

Induction of Anti-Mammary Cancer Immunity by Engaging the OX-40 Receptor in Vivo

2001 • 80 citations

OX40 Ligand and CD30 Ligand Are Expressed on Adult but Not Neonatal CD4+CD3− Inducer Cells: Evidence That IL-7 Signals Regulate CD30 Ligand but Not OX40 Ligand Expression

2005 • 79 citations

Augmentation Versus Inhibition: Effects of Conjunctional OX-40 Receptor Monoclonal Antibody and IL-2 Treatment on Adoptive Immunotherapy of Advanced Tumor

2001 • 78 citations

Costimulatory wars: the tumor menace

2000 • 78 citations

CD4+ T-cells in the regulation of inflammatory responses in the intestine

1997 • 76 citations

Functional expression of CD134 by neutrophils

2004 • 76 citations

CD28-independent induction of experimental autoimmune encephalomyelitis

2001 • 75 citations

Kinetic of regulatory CD25^high and activated CD134⁺ (OX40) T lymphocytes during acute and chronic graft‐versus‐host disease after allogeneic bone marrow transplantation

2004 • 75 citations

The intestinal flora in inflammatory bowel disease: normal or abnormal?

2005 • 70 citations

The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells

1998 • 67 citations

OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response

2003 • 67 citations

Neutrality of the Canonical NF-κB-Dependent Pathway for Human and Murine Cytomegalovirus Transcription and Replication In Vitro

2003 • 65 citations

4‐1BB and OX40 stimulation enhance CD8 and CD4 T‐cell responses to a DNA prime, poxvirus boost vaccine

2004 • 65 citations

CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

2003 • 64 citations

The role of ICOS and other costimulatory molecules in allergy and asthma

2004 • 63 citations

The Role of OX40 Ligand Interactions in the Development of the Th2 Response to the Gastrointestinal Nematode Parasite Heligmosomoides polygyrus

2003 • 63 citations

Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation

2004 • 62 citations

Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease

1998 • 59 citations

Anti-tumour therapeutic efficacy of OX40L in murine tumour model

2004 • 58 citations

Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5

2002 • 56 citations

Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor–reactive cytotoxic T lymphocytes

2004 • 55 citations

Therapeutic effect of anti-OX40L and anti-TNF-α MAbs in a murine model of chronic colitis

2003 • 55 citations

The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement

2004 • 55 citations

Multiple Levels of Activation of Murine CD8+ Intraepithelial Lymphocytes Defined by OX40 (CD134) Expression: Effects on Cell-Mediated Cytotoxicity, IFN-γ, and IL-10 Regulation

2001 • 55 citations

OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses

2003 • 51 citations

The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)

2000 • 50 citations

Expression of tumour necrosis factor (TNF) ligand superfamily co‐stimulatory molecules CD30L, CD27L, OX40L, and 4‐1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3

2001 • 50 citations

Induction of Allograft Tolerance in the Absence of Fas-Mediated Apoptosis

1999 • 50 citations

Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues

1995 • 49 citations

CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle

2005 • 48 citations

Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

2002 • 48 citations

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

2003 • 48 citations

Enhancement of the anti-tumor immune response using a combination of interferon-γ and B7 expression in an experimental mammary carcinoma

1998 • 47 citations

Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation

2001 • 47 citations

Potential immunogenicity of adult T cell leukemia cells in vivo

2004 • 46 citations

OX40 Ligation on Activated T Cells Enhances the Control ofCryptococcus neoformansand Reduces Pulmonary Eosinophilia

2003 • 46 citations

Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system

2000 • 45 citations

T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen.

2001 • 45 citations

The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma

1999 • 43 citations

Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions

2004 • 43 citations

Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40

2000 • 42 citations

Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection

2004 • 41 citations

Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

2001 • 41 citations

OX40 (CD134) Blockade Inhibits the Co-stimulatory Cascade and Promotes Heart Allograft Survival

2004 • 40 citations

The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells

2005 • 39 citations

Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery

1999 • 37 citations

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand

2003 • 37 citations

The pathophysiologic rationale for biological therapies in inflammatory bowel disease.

2005 • 36 citations

NF-κB activation and HIV-1 induced apoptosis

1999 • 35 citations

Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium

2004 • 35 citations

OX40 Stimulation by gp34/OX40 Ligand Enhances Productive Human Immunodeficiency Virus Type 1 Infection

2001 • 34 citations

V? CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of lewis rats with EAE

1996 • 34 citations

The comparison of expression of cutaneous lymphocyte-associated antigen (CLA), and Th1- and Th2-associated antigens in mycosis fungoides and cutaneous lesions of adult T-cell leukemia/lymphoma.

2004 • 34 citations

CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis.

2005 • 32 citations

Localization of OX40/gp34 in inflammatory skin diseases: a clue to elucidate the interaction between activated T cells and endothelial cells in infiltration

1997 • 32 citations

Allorecognition and graft-versus-host disease.

1995 • 30 citations

OX40–Mediated Cosignal Enhances the Maturation of Naive Human CD4+ T Cells into High IL–4–Producing Effectors

1999 • 28 citations

CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co‐stimulation in the induction of allergic lower airways disease

2003 • 27 citations

Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein

1995 • 27 citations

A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production

2003 • 27 citations

Effects of Combined Treatment with CD25- and CD154-Specific Monoclonal Antibodies in Non-Human Primate Allotransplantation

2003 • 26 citations

What Is the Mechanism of Action of Anti-Tumour Necrosis Factor-α Antibody in Rheumatoid Arthritis?

1996 • 26 citations

GM-CSF and B7-1 (CD80) co-stimulatory signals co-operate in the induction of effective anti-tumor immunity in syngeneic mice

1997 • 25 citations

Phenotypic Characterization of Subsets of T Cell Lymphoma: Towards a Functional Classification of T Cell Lymphoma

2001 • 24 citations

Identification of OX40 ligand and preliminary characterization of its activities on OX40 receptor.

1994 • 24 citations

Characterization and functional study of five novel monoclonal antibodies against human OX40L highlight reverse signalling: enhancement of IgG production of B cells and promotion of maturation of DCs

2004 • 23 citations

The HTLV-I Tax Protein Transcriptionally Modulates OX40 Antigen Expression

2000 • 22 citations

Requirement for CD28 in the Effector Phase of Allergic Airway Inflammation

2004 • 22 citations

Insights into the Pathogenesis of Type 1 Diabetes A Hint for Novel Immunospecific Therapies

2001 • 22 citations

Enhanced T Lymphocyte Expression of LFA‐1, ICAM‐1, and the TNF Receptor Family Member OX40 in HgCl₂‐Induced Systemic Autoimmunity

1996 • 20 citations

Expression of tumour necrosis factor (TNF) receptor/ligand superfamily co-stimulatory molecules CD40, CD30L, CD27L, and OX40L in murine hearts with chronic ongoing myocarditis caused by Coxsackie virus B3

1999 • 19 citations

Expression of OX40 in muscles of polymyositis and granulomatous myopathy

2002 • 19 citations

Retroviral transduction of acute myeloid leukaemia‐derived dendritic cells with OX40 ligand augments their antigen presenting activity

2004 • 18 citations

Acute rejection of marrow grafts in patients transplanted from a partially mismatched related donor: clinical and immunologic characteristics.

1996 • 17 citations

Expression of T-cell activation marker CD134 (OX40) in lymphomatoid papulosis

2003 • 17 citations

Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy

2002 • 17 citations

Autoimmune diabetes: How many steps for one disease?

1997 • 16 citations

Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells

2002 • 15 citations

Expression of T cell activation antigen CD134 (OX40) has no predictive value for the occurrence or response to therapy of acute graft-versus-host disease in partial T cell-depleted bone marrow transplantation

1999 • 15 citations

A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones.

1997 • 14 citations

OX40 Signaling Renders Adult T-Cell Leukemia Cells Resistant to Fas-Induced Apoptosis

2002 • 13 citations

Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft1

2002 • 10 citations

CD25 expression distinguishes functionally distinct alloreactive CD4+ CD134+ (OX40+) T-cell subsets in acute graft-versus-host disease

2004 • 10 citations

Type 1 diabetes: MHC tailored for diabetes cell therapy

2005 • 10 citations