NF-κB activation and HIV-1 induced apoptosis

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The Bcl-2 Protein Family: Arbiters of Cell Survival

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Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Social controls on cell survival and cell death

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Suppression of TNF-α-Induced Apoptosis by NF-κB

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IκB: a Specific Inhibitor of the NF-κB Transcription Factor

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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Genetic control of programmed cell death in the nematode C. elegans

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

1999 • 725 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

1997 • 600 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 • 563 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Macrophages as a Source of HIV During Opportunistic Infections

1997 • 543 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

IκB–NF-κB Structures

1998 • 439 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1996 • 420 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

Apoptosis in AIDS

1993 • 375 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

1999 • 363 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1998 • 347 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

IκB proteins: structure, function and regulation

1997 • 330 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

1996 • 316 citations

The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators

1999 • 314 citations

Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome

1998 • 312 citations

IKAP is a scaffold protein of the IκB kinase complex

1998 • 294 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

HIV-1 Tat protein mimicry of chemokines

1998 • 278 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

A20 zinc finger protein inhibits TNF and IL-1 signaling.

1996 • 250 citations

Macrophage-dependent Apoptosis of CD4+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor

1997 • 242 citations

Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

1999 • 232 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

PKR: a new name and new roles

1995 • 223 citations

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- alpha secretion

1994 • 220 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases

1999 • 208 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability

1996 • 199 citations

Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB

1999 • 196 citations

Early events in TNF signaling: a story of associations and dissociations

1997 • 194 citations

Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8

1999 • 191 citations

Rapid Loss of CD4 ⁺ T Cells in Human-PBL-SCID Mice by Noncytopathic HIV Isolates

1993 • 189 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

The inhibitory ankyrin and activator Rel proteins

1992 • 185 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1

1999 • 181 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

1989 • 169 citations

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

1997 • 168 citations

Type I interferons are essential mediators of apoptotic death in virally infected cells

1998 • 166 citations

Distinct Functional Properties of IκBα and IκBβ

1997 • 166 citations

Constitutive Phosphorylation of IκBα by Casein Kinase II Occurs Preferentially at Serine 293: Requirement for Degradation of Free IκBα

1996 • 164 citations

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

1995 • 160 citations

NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation

1998 • 155 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

The Tax Oncoprotein of Human T-cell Leukemia Virus Type 1 Associates with and Persistently Activates IκB Kinases Containing IKKα and IKKβ

1998 • 152 citations

Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors

1995 • 151 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes

1998 • 140 citations

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB

1995 • 123 citations

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

1991 • 116 citations

Regulation of IκBβ Degradation

1997 • 109 citations

HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking?

1998 • 108 citations

Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR

1999 • 104 citations

Differential Transcriptional Activation in Vitro by NF- κB/Rel Proteins

1995 • 101 citations

Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions

1996 • 101 citations

Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites

1995 • 96 citations

Infection and Apoptotic Cell Death of CD4⁺T Cells during an Immune Response to HIV-1-Pulsed Dendritic Cells

1994 • 95 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

Signal-Induced Degradation of IκBα: Association with NF-κB and the PEST Sequence in IκBα Are Not Required

1996 • 90 citations

Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription.

1994 • 90 citations

Differential induction of nuclear NF-kappa B by protein phosphatase inhibitors in primary and transformed human cells. Requirement for both oxidation and phosphorylation in nuclear translocation.

1993 • 89 citations

HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells.

1994 • 87 citations

Inducible Expression of IκBα Repressor Mutants Interferes with NF-κB Activity and HIV-1 Replication in Jurkat T Cells

1998 • 85 citations

Recent advances in tumor necrosis factor and CD40 signaling

1996 • 85 citations

Tumor Suppressor p53 as a Component of the Tumor Necrosis Factor-induced, Protein Kinase PKR-mediated Apoptotic Pathway in Human Promonocytic U937 Cells

1998 • 85 citations

Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

1997 • 85 citations

Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by Divergent Embryonic Expression Patterns: Only jak2a Is Expressed During Erythropoiesis

1999 • 83 citations

Cell killing by avian leukosis viruses

1981 • 78 citations

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB

1997 • 78 citations

Vpu Increases Susceptibility of Human Immunodeficiency Virus Type 1-Infected Cells to Fas Killing

1999 • 75 citations

Regulation of IκBβ in WEHI 231 Mature B Cells

1997 • 74 citations

Recent Progress on the Regulation of Apoptosis by Bcl-2 Family Members

1998 • 72 citations

LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha

1995 • 72 citations

Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1

1995 • 64 citations

Involvement of a Putative Protein-tyrosine Phosphatase and IκB-α Serine Phosphorylation in Nuclear Factor κB Activation by Tumor Necrosis Factor

1995 • 60 citations

IFN-gamma influences the migration of thoracic duct B and T lymphocyte subsets in vivo. Random increase in disappearance from the blood and differential decrease in reappearance in the lymph.

1993 • 56 citations

Nuclear IκBβ Maintains Persistent NF-κB Activation in HIV-1-infected Myeloid Cells

1999 • 56 citations

Evidence in Support of a Role for Human T-cell Leukemia Virus Type I Tax in Activating NF-ƘB via Stimulation of Signaling Pathways

1995 • 55 citations

Expression of Constitutively Active IκBβ in T Cells of Transgenic Mice: Persistent NF-κB Activity Is Required for T-Cell Immune Responses

1998 • 54 citations

Inactivation of NF-κB Inhibitor IκBα: Ubiquitin-Dependent Proteolysis and Its Degradation Product

1995 • 53 citations

Taxol selectively blocks microtubule dependent NF-κB activation by phorbol ester via inhibition of IκBα phosphorylation and degradation

1999 • 53 citations

Signal transduction from the Epstein–Barr virus LMP-1 transforming protein

1998 • 52 citations

Phosphorylation of the PEST Domain of IκBβ Regulates the Function of NF-κB/IκBβ Complexes

1997 • 51 citations

Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication

1996 • 51 citations

The Protein Tyrosine Kinase p56^lckIs Required for Triggering NF-κB Activation upon Interaction of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp120 with Cell Surface CD4

1998 • 49 citations

Potent and Stable Attenuation of Live-HIV-1 by Gain of a Proteolysis-resistant Inhibitor of NF-κB (IκB-αS32/36A) and the Implications for Vaccine Development

1999 • 45 citations

The Role of CD4 in HIV Envelope-Mediated Pathogenesis

1996 • 45 citations

Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58^IPK

1999 • 40 citations

Molecular Interactions between HTLV-1 Tax Protein and the NF-κB/IκB Transcription Complex

1995 • 39 citations

The Role of the C-terminal Domain of IκBα in Protein Degradation and Stabilization

1996 • 38 citations

NF-κB Protects HIV-1-Infected Myeloid Cells from Apoptosis

1998 • 37 citations

Chimaeric anti‐CD4 monoclonal antibody cross‐linked by monocyte Fcγ receptor mediates apoptosis of human CD4 lymphocytes

1993 • 36 citations

Association between HTLV-1 Tax and IκBα Is Dependent on the IκBα Phosphorylation State

1998 • 34 citations

Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation

1996 • 34 citations

Iκκ Mediates NF-κB Activation in Human Immunodeficiency Virus-Infected Cells

1999 • 33 citations

The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalpha.

1996 • 30 citations

NF-κB activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I

1991 • 30 citations

Induction of CD4⁺ T cell depletion in mice doubly transgenic for HIV gp120 and human CD4

1997 • 27 citations

Human T Cell Leukemia Virus Type 1 Tax Protein Increases NF-κB Dimer Formation and Antagonizes the Inhibitory Activity of the IκBα Regulatory Protein

1996 • 23 citations

The Serine/Threonine Phosphatase Inhibitor Calyculin A Induces Rapid Degradation of IκBβ

1997 • 20 citations

Human PKR Transfected into Murine Cells Stimulates Expression of Genes under Control of the HIV1 or HTLV-I LTR

1995 • 18 citations

Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

1997 • 17 citations

Deleted Work

1955 • 0 citations