Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

1996 • 411 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

1999 • 351 citations

CELLS MEDIATING ALLOGRAFT REJECTION

1991 • 330 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

CD4+ but not CD8+ cells are essential for allorejection.

1996 • 303 citations

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.

1994 • 227 citations

Role of CD28-B7 Interactions in Generation and Maintenance of CD8 T Cell Memory

2001 • 192 citations

CD28 Costimulation Mediates Down-Regulation of p27kip1and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells

2002 • 191 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

The Role of Novel T Cell Costimulatory Pathways in Autoimmunity and Transplantation

2002 • 165 citations

CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

2000 • 153 citations

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

1999 • 143 citations

Antigen processing and presentation in transplantation

1996 • 140 citations

Cutting Edge: Blockade of the CD28/B7 Costimulatory Pathway Inhibits Intestinal Allograft Rejection Mediated by CD4+ But Not CD8+ T Cells

1999 • 125 citations

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 • 103 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

IL-2 and IL-4 Double Knockout Mice Reject Islet Allografts: A Role for Novel T Cell Growth Factors in Allograft Rejection

1998 • 94 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Cutting Edge: Regulation of CD8+ T Cell Proliferation by 2B4/CD48 Interactions

2001 • 80 citations

A Critical Role for Cd40–Cd40 Ligand Interactions in Amplification of the Mucosal Cd8 T Cell Response

1999 • 79 citations

An Antagonist IL-15/Fc Protein Prevents Costimulation Blockade-Resistant Rejection

2001 • 77 citations

Blocking the Common γ-Chain of Cytokine Receptors Induces T Cell Apoptosis and Long-Term Islet Allograft Survival

2000 • 75 citations

The Role of Autoimmunity in Islet Allograft Destruction

2002 • 67 citations

Contrasting Alloreactive CD4+ and CD8+ T Cells: There's More to It Than MHC Restriction

2003 • 52 citations

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.

1997 • 48 citations

Role of JAK3 in CD40-Mediated Signaling

1998 • 34 citations

On CD28/CD40 Ligand Costimulation, Common γ-Chain Signals, and the Alloimmune Response

2002 • 24 citations

T-cell growth factors and the allograft response

2003 • 4 citations