New therapies for rheumatoid arthritis

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

2000 • 2,992 citations

American college of rheumatology preliminary definition of improvement in rheumatoid arthritis

1995 • 2,778 citations

Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States

1998 • 2,707 citations

Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

2004 • 2,504 citations

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

1999 • 2,358 citations

Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

2001 • 2,229 citations

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

1999 • 2,117 citations

Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20

1994 • 1,932 citations

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

2004 • 1,787 citations

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2000 • 1,757 citations

Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial

2003 • 1,750 citations

IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

1997 • 1,652 citations

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis

1998 • 1,642 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

2003 • 1,504 citations

Etanercept Therapy in Rheumatoid Arthritis

1999 • 1,407 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS

1989 • 1,137 citations

INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

1998 • 1,048 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

1998 • 956 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Demyelination occurring during anti-tumor necrosis factor ? therapy for inflammatory arthritides

2001 • 813 citations

Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial

2004 • 790 citations

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial

1999 • 772 citations

Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Placebo and Methotrexate

1999 • 748 citations

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

2000 • 713 citations

Tumor necrosis factor antagonist therapy and lymphoma development: Twenty‐six cases reported to the Food and Drug Administration

2002 • 668 citations

Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications

1996 • 647 citations

New Drugs for Rheumatoid Arthritis

2004 • 643 citations

Lymphoma in rheumatoid arthritis: The effect of methotrexate and anti–tumor necrosis factor therapy in 18,572 patients

2004 • 643 citations

Accelerated atherosclerosis: An extraarticular feature of rheumatoid arthritis?

2002 • 616 citations

Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies

2001 • 590 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura

2001 • 553 citations

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1996 • 538 citations

Therapeutic benefit of blocking interleukin‐6 activity with an anti–interleukin‐6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled, dose‐escalation trial

2002 • 531 citations

Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology

2001 • 529 citations

Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes

2001 • 523 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

The comparative efficacy and toxicity of second‐line drugs in rheumatoid arthritis results of two metaanalyses

1990 • 471 citations

The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis: Results from ATTRACT, a multicenter, randomized, double‐blind, placebo‐controlled trial

2002 • 417 citations

A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of genant and larsen scores

2000 • 408 citations

Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case-control study

1998 • 394 citations

Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor α blockade in patients with rheumatoid arthritis

2000 • 394 citations

Anakinra, a recombinant human interleukin‐1 receptor antagonist (r‐metHuIL‐1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo‐controlled trial

2003 • 384 citations

Concomitant Leflunomide Therapy in Patients with Active Rheumatoid Arthritis despite Stable Doses of Methotrexate

2002 • 349 citations

Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion

2002 • 345 citations

Serious bacterial infections in patients with rheumatoid arthritis under anti-TNF-alpha therapy

2003 • 334 citations

Invasive Pulmonary Aspergillosis Associated with Infliximab Therapy

2001 • 332 citations

Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5 year followup of a prospective double blind placebo controlled study.

1995 • 316 citations

Joint Erosions and Patients with Early Rheumatoid Arthritis

1995 • 316 citations

Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate

2001 • 292 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first‐degree relatives

2003 • 270 citations

Rituximab monoclonal antibody as initial systemic therapy for patients with low-grade non-Hodgkin lymphoma

2000 • 267 citations

Rituximab monoclonal antibody as initial systemic therapy for patients with low-grade non-Hodgkin lymphoma

2000 • 242 citations

Long‐term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin‐1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double‐blind, placebo‐controlled trial

2002 • 215 citations

Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

1994 • 214 citations

Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial

2002 • 210 citations

Inhibition of IL-6 for the treatment of inflammatory diseases

2004 • 201 citations

Do self‐perpetuating B lymphocytes drive human autoimmune disease?

1999 • 176 citations

Consequences of delayed therapy with second-line agents in rheumatoid arthritis: a 3 year followup on the hydroxychloroquine in early rheumatoid arthritis (HERA) study.

2000 • 164 citations

Methotrexate in Rheumatoid Arthritis

1987 • 153 citations

Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis.

1992 • 133 citations

Pharmacokinetics of anakinra in subjects with different levels of renal function

2003 • 128 citations

Reduction in long-term functional disability in rheumatoid arthritis from 1977 to 1998:a longitudinal study of 3035 patients

2003 • 105 citations

Systemic lupus erythematosus after heavy exposure to quartz dust in uranium mines: clinical and serological characteristics

1996 • 104 citations

Reassessment of Twelve Traditional Paradigms Concerning the Diagnosis, Prevalence, Morbidity and Mortality of Rheumatoid Arthritis

1989 • 103 citations

Low‐dose corticosteroids in rheumatoid arthritis. A meta‐analysis of their moderate‐term effectiveness

1996 • 99 citations

METHOTREXATE USE IN RHEUMATOID ARTHRITIS

1997 • 97 citations

Combination therapy in rheumatoid arthritis: updated systematic review

1998 • 96 citations

Glucocorticoids and rheumatoid arthritis: Back to the future?

2002 • 92 citations

COMORBIDITY IN RHEUMATOID ARTHRITIS

2001 • 91 citations

Listeria Meningitis After Treatment With Infliximab

2002 • 87 citations

PROSPECTIVE LONG TERM FOLLOW-UP OF METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS: TOXICITY, EFFICACY AND RADIOLOGICAL PROGRESSION

1989 • 85 citations

Interleukin-6 and its receptor in autoimmunity

1992 • 82 citations

Safety of tacrolimus in patients with rheumatoid arthritis: long-term experience

2004 • 76 citations

Comparison of intramuscular methotrexate and gold sodium thiomalate in the treatment of early erosive rheumatoid arthritis: 12 month data of a double-blind parallel study of 174 patients

1997 • 72 citations

INTERLEUKIN-1 RECEPTOR ANTAGONIST

1998 • 68 citations

New drugs for the treatment of rheumatoid arthritis

2000 • 68 citations

Disease-modifying anti-rheumatic drugs

2006 • 66 citations

IgG Rheumatoid Factors and Self-association of These Antibodies

1985 • 58 citations

INJECTABLE GOLD COMPOUNDS: AN OVERVIEW

1995 • 55 citations

Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells

1983 • 54 citations

Efficacy of Methotrexate in Rheumatoid Arthritis

1995 • 54 citations

Leflunomide-associated weight loss in rheumatoid arthritis

2001 • 52 citations

Efficacy of Methotrexate in Rheumatoid Arthritis

1995 • 33 citations

The methotrexate therapeutic response in rheumatoid arthritis.

2002 • 29 citations

A three year comparative multicenter study of auranofin (AF) and gold sodium thiomalate (GST) in the treatment of rheumatoid arthritis (RA)

1987 • 7 citations

Disease-modifying antirheumatic drugs

1998 • 7 citations

The use of antimalarials in combination with other disease modifying agents in RA – the British experience

1996 • 3 citations